Cerebral autoregulation dynamics in endurance-trained individuals

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Cerebral autoregulation dynamics in endurance-trained individuals. / Lind-Holst, Mikkel; Cotter, James D; Helge, Jørn W; Boushel, Robert Christopher; Augustesen, Helene; Van Lieshout, Johannes J; Pott, Frank C.

I: Journal of Applied Physiology, Bind 110, Nr. 5, 2011, s. 1327-33.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Lind-Holst, M, Cotter, JD, Helge, JW, Boushel, RC, Augustesen, H, Van Lieshout, JJ & Pott, FC 2011, 'Cerebral autoregulation dynamics in endurance-trained individuals', Journal of Applied Physiology, bind 110, nr. 5, s. 1327-33. https://doi.org/10.1152/japplphysiol.01497.2010

APA

Lind-Holst, M., Cotter, J. D., Helge, J. W., Boushel, R. C., Augustesen, H., Van Lieshout, J. J., & Pott, F. C. (2011). Cerebral autoregulation dynamics in endurance-trained individuals. Journal of Applied Physiology, 110(5), 1327-33. https://doi.org/10.1152/japplphysiol.01497.2010

Vancouver

Lind-Holst M, Cotter JD, Helge JW, Boushel RC, Augustesen H, Van Lieshout JJ o.a. Cerebral autoregulation dynamics in endurance-trained individuals. Journal of Applied Physiology. 2011;110(5):1327-33. https://doi.org/10.1152/japplphysiol.01497.2010

Author

Lind-Holst, Mikkel ; Cotter, James D ; Helge, Jørn W ; Boushel, Robert Christopher ; Augustesen, Helene ; Van Lieshout, Johannes J ; Pott, Frank C. / Cerebral autoregulation dynamics in endurance-trained individuals. I: Journal of Applied Physiology. 2011 ; Bind 110, Nr. 5. s. 1327-33.

Bibtex

@article{7867b297d23349b6ba6313384f50db6b,
title = "Cerebral autoregulation dynamics in endurance-trained individuals",
abstract = "Aerobic fitness may be associated with reduced orthostatic tolerance. To investigate whether trained individuals have less effective regulation of cerebral vascular resistance, we studied the middle cerebral artery (MCA) mean blood velocity (V(mean)) response to a sudden drop in mean arterial pressure (MAP) after 2.5 min of leg ischemia in endurance athletes and untrained subjects (maximal O(2) uptake: 69 ± 7 vs. 42 ± 5 ml O(2)·min(-1)·kg(-1); n = 9 for both, means ± SE). After cuff release when seated, endurance athletes had larger drops in MAP (94 ± 6 to 62 ± 5 mmHg, -39%, vs. 99 ± 5 to 73 ± 4 mmHg, -26%) and MCA V(mean) (53 ± 3 to 37 ± 2 cm/s, -30%, vs. 58 ± 3 to 43 ± 2 cm/s, -25%). The athletes also had a slower recovery to baseline of both MAP (25 ± 2 vs. 16 ± 1 s, P <0.01) and MCA V(mean) (15 ± 1 vs. 11 ± 1 s, P <0.05). The onset of autoregulation, determined by the time point of increase in the cerebrovascular conductance index (CVCi = MCA V(mean)/MAP) appeared later in the athletes (3.9 ± 0.4 vs. 2.7 ± 0.4s, P = 0.01). Spectral analysis revealed a normal MAP-to-MCA V(mean) phase in both groups but ~40% higher normalized MAP to MCA V(mean) low-frequency transfer function gain in the trained subjects. No significant differences were detected in the rates of recovery of MAP and MCA V(mean) and the rate of CVCi regulation (18 ± 4 vs. 24 ± 7%/s, P = 0.2). In highly trained endurance athletes, a drop in blood pressure after the release of resting leg ischemia was more pronounced than in untrained subjects and was associated with parallel changes in indexes of cerebral blood flow. Once initiated, the autoregulatory response was similar between the groups. A delayed onset of autoregulation with a larger normalized transfer gain conforms with a less effective dampening of MAP oscillations, indicating that athletes may be more prone to instances of symptomatic cerebral hypoperfusion when MAP declines.",
author = "Mikkel Lind-Holst and Cotter, {James D} and Helge, {J{\o}rn W} and Boushel, {Robert Christopher} and Helene Augustesen and {Van Lieshout}, {Johannes J} and Pott, {Frank C}",
year = "2011",
doi = "10.1152/japplphysiol.01497.2010",
language = "English",
volume = "110",
pages = "1327--33",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "5",

}

RIS

TY - JOUR

T1 - Cerebral autoregulation dynamics in endurance-trained individuals

AU - Lind-Holst, Mikkel

AU - Cotter, James D

AU - Helge, Jørn W

AU - Boushel, Robert Christopher

AU - Augustesen, Helene

AU - Van Lieshout, Johannes J

AU - Pott, Frank C

PY - 2011

Y1 - 2011

N2 - Aerobic fitness may be associated with reduced orthostatic tolerance. To investigate whether trained individuals have less effective regulation of cerebral vascular resistance, we studied the middle cerebral artery (MCA) mean blood velocity (V(mean)) response to a sudden drop in mean arterial pressure (MAP) after 2.5 min of leg ischemia in endurance athletes and untrained subjects (maximal O(2) uptake: 69 ± 7 vs. 42 ± 5 ml O(2)·min(-1)·kg(-1); n = 9 for both, means ± SE). After cuff release when seated, endurance athletes had larger drops in MAP (94 ± 6 to 62 ± 5 mmHg, -39%, vs. 99 ± 5 to 73 ± 4 mmHg, -26%) and MCA V(mean) (53 ± 3 to 37 ± 2 cm/s, -30%, vs. 58 ± 3 to 43 ± 2 cm/s, -25%). The athletes also had a slower recovery to baseline of both MAP (25 ± 2 vs. 16 ± 1 s, P <0.01) and MCA V(mean) (15 ± 1 vs. 11 ± 1 s, P <0.05). The onset of autoregulation, determined by the time point of increase in the cerebrovascular conductance index (CVCi = MCA V(mean)/MAP) appeared later in the athletes (3.9 ± 0.4 vs. 2.7 ± 0.4s, P = 0.01). Spectral analysis revealed a normal MAP-to-MCA V(mean) phase in both groups but ~40% higher normalized MAP to MCA V(mean) low-frequency transfer function gain in the trained subjects. No significant differences were detected in the rates of recovery of MAP and MCA V(mean) and the rate of CVCi regulation (18 ± 4 vs. 24 ± 7%/s, P = 0.2). In highly trained endurance athletes, a drop in blood pressure after the release of resting leg ischemia was more pronounced than in untrained subjects and was associated with parallel changes in indexes of cerebral blood flow. Once initiated, the autoregulatory response was similar between the groups. A delayed onset of autoregulation with a larger normalized transfer gain conforms with a less effective dampening of MAP oscillations, indicating that athletes may be more prone to instances of symptomatic cerebral hypoperfusion when MAP declines.

AB - Aerobic fitness may be associated with reduced orthostatic tolerance. To investigate whether trained individuals have less effective regulation of cerebral vascular resistance, we studied the middle cerebral artery (MCA) mean blood velocity (V(mean)) response to a sudden drop in mean arterial pressure (MAP) after 2.5 min of leg ischemia in endurance athletes and untrained subjects (maximal O(2) uptake: 69 ± 7 vs. 42 ± 5 ml O(2)·min(-1)·kg(-1); n = 9 for both, means ± SE). After cuff release when seated, endurance athletes had larger drops in MAP (94 ± 6 to 62 ± 5 mmHg, -39%, vs. 99 ± 5 to 73 ± 4 mmHg, -26%) and MCA V(mean) (53 ± 3 to 37 ± 2 cm/s, -30%, vs. 58 ± 3 to 43 ± 2 cm/s, -25%). The athletes also had a slower recovery to baseline of both MAP (25 ± 2 vs. 16 ± 1 s, P <0.01) and MCA V(mean) (15 ± 1 vs. 11 ± 1 s, P <0.05). The onset of autoregulation, determined by the time point of increase in the cerebrovascular conductance index (CVCi = MCA V(mean)/MAP) appeared later in the athletes (3.9 ± 0.4 vs. 2.7 ± 0.4s, P = 0.01). Spectral analysis revealed a normal MAP-to-MCA V(mean) phase in both groups but ~40% higher normalized MAP to MCA V(mean) low-frequency transfer function gain in the trained subjects. No significant differences were detected in the rates of recovery of MAP and MCA V(mean) and the rate of CVCi regulation (18 ± 4 vs. 24 ± 7%/s, P = 0.2). In highly trained endurance athletes, a drop in blood pressure after the release of resting leg ischemia was more pronounced than in untrained subjects and was associated with parallel changes in indexes of cerebral blood flow. Once initiated, the autoregulatory response was similar between the groups. A delayed onset of autoregulation with a larger normalized transfer gain conforms with a less effective dampening of MAP oscillations, indicating that athletes may be more prone to instances of symptomatic cerebral hypoperfusion when MAP declines.

U2 - 10.1152/japplphysiol.01497.2010

DO - 10.1152/japplphysiol.01497.2010

M3 - Journal article

C2 - 21372098

VL - 110

SP - 1327

EP - 1333

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 5

ER -

ID: 33815636