Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure

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Standard

Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure. / Hejl, Julie L.; Grand, Mia K.; Siersma, Volkert; Goetze, Jens P.; Olivarius, Niels de Fine; Andersen, Christen L.; Lind, Bent.

I: Clinical Chemistry, Bind 64, Nr. 12, 12.2018, s. 1723-1731.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Hejl, JL, Grand, MK, Siersma, V, Goetze, JP, Olivarius, NDF, Andersen, CL & Lind, B 2018, 'Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure', Clinical Chemistry, bind 64, nr. 12, s. 1723-1731. https://doi.org/10.1373/clinchem.2018.293480

APA

Hejl, J. L., Grand, M. K., Siersma, V., Goetze, J. P., Olivarius, N. D. F., Andersen, C. L., & Lind, B. (2018). Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure. Clinical Chemistry, 64(12), 1723-1731. https://doi.org/10.1373/clinchem.2018.293480

Vancouver

Hejl JL, Grand MK, Siersma V, Goetze JP, Olivarius NDF, Andersen CL o.a. Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure. Clinical Chemistry. 2018 dec;64(12):1723-1731. https://doi.org/10.1373/clinchem.2018.293480

Author

Hejl, Julie L. ; Grand, Mia K. ; Siersma, Volkert ; Goetze, Jens P. ; Olivarius, Niels de Fine ; Andersen, Christen L. ; Lind, Bent. / Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure. I: Clinical Chemistry. 2018 ; Bind 64, Nr. 12. s. 1723-1731.

Bibtex

@article{c95d0cb952a24e7db7ad5798fc0832ac,
title = "Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure",
abstract = "BACKGROUND: Measurement of B-type natriuretic peptide (BNP) in plasma may have its greatest potential in primary care, as general practitioners need to rapidly identify patients who warrant further medical review. The aim of the present study was to examine the prognostic information of BNP measurement on all-cause mortality in a large Danish primary care cohort. METHODS: This study covered a cohort of Danish primary care patients (n = 61665) with a median follow-up period of 4.36 years (interquartile range, 2.29-6.62 years). BNP was measured in plasma using the ADVIA Centaur/ CentaurXP platform. The association of BNP with mortality was assessed with a hazard ratio for all-cause mortality from a multivariable Cox proportional hazards model. RESULTS: Kaplan-Meier curves showed decreasing survival probability with increasing BNP (P < 0.001). Each doubling of BNP increased mortality by 32.3{\%} (95{\%} CI, 30.8-33.8) when adjusted for sex and age, and by 25.3{\%} (95{\%} CI, 23.8-26.8) when further adjusted for Charlson comorbidity index, hemoglobin, estimated glomerular filtration rate, glycohemoglobin, and thyroid-stimulating hormone. Also, in a subcohort (n=10824) without biochemical signs of severe kidney failure, anemia, polycythemia, hypothyroidism or hyperthyroidism, or dysregulated diabetes, each doubling of BNP increased mortality by 28.6{\%} (95{\%} CI, 22.8-34.7). CONCLUSIONS: Our results show that even in a primary care population, BNP measurements contain prognostic information regarding all-cause mortality.",
author = "Hejl, {Julie L.} and Grand, {Mia K.} and Volkert Siersma and Goetze, {Jens P.} and Olivarius, {Niels de Fine} and Andersen, {Christen L.} and Bent Lind",
year = "2018",
month = "12",
doi = "10.1373/clinchem.2018.293480",
language = "English",
volume = "64",
pages = "1723--1731",
journal = "Clinical Chemistry",
issn = "0009-9147",
publisher = "American Association for Clinical Chemistry, Inc.",
number = "12",

}

RIS

TY - JOUR

T1 - Brain Natriuretic Peptide in Plasma as Predictor of All-Cause Mortality in a Large Danish Primary Health Care Population Suspected of Heart Failure

AU - Hejl, Julie L.

AU - Grand, Mia K.

AU - Siersma, Volkert

AU - Goetze, Jens P.

AU - Olivarius, Niels de Fine

AU - Andersen, Christen L.

AU - Lind, Bent

PY - 2018/12

Y1 - 2018/12

N2 - BACKGROUND: Measurement of B-type natriuretic peptide (BNP) in plasma may have its greatest potential in primary care, as general practitioners need to rapidly identify patients who warrant further medical review. The aim of the present study was to examine the prognostic information of BNP measurement on all-cause mortality in a large Danish primary care cohort. METHODS: This study covered a cohort of Danish primary care patients (n = 61665) with a median follow-up period of 4.36 years (interquartile range, 2.29-6.62 years). BNP was measured in plasma using the ADVIA Centaur/ CentaurXP platform. The association of BNP with mortality was assessed with a hazard ratio for all-cause mortality from a multivariable Cox proportional hazards model. RESULTS: Kaplan-Meier curves showed decreasing survival probability with increasing BNP (P < 0.001). Each doubling of BNP increased mortality by 32.3% (95% CI, 30.8-33.8) when adjusted for sex and age, and by 25.3% (95% CI, 23.8-26.8) when further adjusted for Charlson comorbidity index, hemoglobin, estimated glomerular filtration rate, glycohemoglobin, and thyroid-stimulating hormone. Also, in a subcohort (n=10824) without biochemical signs of severe kidney failure, anemia, polycythemia, hypothyroidism or hyperthyroidism, or dysregulated diabetes, each doubling of BNP increased mortality by 28.6% (95% CI, 22.8-34.7). CONCLUSIONS: Our results show that even in a primary care population, BNP measurements contain prognostic information regarding all-cause mortality.

AB - BACKGROUND: Measurement of B-type natriuretic peptide (BNP) in plasma may have its greatest potential in primary care, as general practitioners need to rapidly identify patients who warrant further medical review. The aim of the present study was to examine the prognostic information of BNP measurement on all-cause mortality in a large Danish primary care cohort. METHODS: This study covered a cohort of Danish primary care patients (n = 61665) with a median follow-up period of 4.36 years (interquartile range, 2.29-6.62 years). BNP was measured in plasma using the ADVIA Centaur/ CentaurXP platform. The association of BNP with mortality was assessed with a hazard ratio for all-cause mortality from a multivariable Cox proportional hazards model. RESULTS: Kaplan-Meier curves showed decreasing survival probability with increasing BNP (P < 0.001). Each doubling of BNP increased mortality by 32.3% (95% CI, 30.8-33.8) when adjusted for sex and age, and by 25.3% (95% CI, 23.8-26.8) when further adjusted for Charlson comorbidity index, hemoglobin, estimated glomerular filtration rate, glycohemoglobin, and thyroid-stimulating hormone. Also, in a subcohort (n=10824) without biochemical signs of severe kidney failure, anemia, polycythemia, hypothyroidism or hyperthyroidism, or dysregulated diabetes, each doubling of BNP increased mortality by 28.6% (95% CI, 22.8-34.7). CONCLUSIONS: Our results show that even in a primary care population, BNP measurements contain prognostic information regarding all-cause mortality.

U2 - 10.1373/clinchem.2018.293480

DO - 10.1373/clinchem.2018.293480

M3 - Journal article

VL - 64

SP - 1723

EP - 1731

JO - Clinical Chemistry

JF - Clinical Chemistry

SN - 0009-9147

IS - 12

ER -

ID: 209681965