Associations between primary care electrocardiography and non-Alzheimer dementia

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Standard

Associations between primary care electrocardiography and non-Alzheimer dementia. / Isaksen, Jonas L; Ghouse, Jonas; Skov, Morten W; Olesen, Morten S; Holst, Anders G; Pietersen, Adrian; Nielsen, Jonas B; Maier, Anja M.; Graff, Claus; Frikke-Schmidt, Ruth; Kanters, Jørgen K.

I: Journal of Stroke & Cerebrovascular Diseases, Bind 31, Nr. 9, 106640, 10.07.2022.

Publikation: Bidrag til tidsskriftTidsskriftartikelfagfællebedømt

Harvard

Isaksen, JL, Ghouse, J, Skov, MW, Olesen, MS, Holst, AG, Pietersen, A, Nielsen, JB, Maier, AM, Graff, C, Frikke-Schmidt, R & Kanters, JK 2022, 'Associations between primary care electrocardiography and non-Alzheimer dementia', Journal of Stroke & Cerebrovascular Diseases, bind 31, nr. 9, 106640. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106640

APA

Isaksen, J. L., Ghouse, J., Skov, M. W., Olesen, M. S., Holst, A. G., Pietersen, A., Nielsen, J. B., Maier, A. M., Graff, C., Frikke-Schmidt, R., & Kanters, J. K. (2022). Associations between primary care electrocardiography and non-Alzheimer dementia. Journal of Stroke & Cerebrovascular Diseases, 31(9), [106640]. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106640

Vancouver

Isaksen JL, Ghouse J, Skov MW, Olesen MS, Holst AG, Pietersen A o.a. Associations between primary care electrocardiography and non-Alzheimer dementia. Journal of Stroke & Cerebrovascular Diseases. 2022 jul. 10;31(9). 106640. https://doi.org/10.1016/j.jstrokecerebrovasdis.2022.106640

Author

Isaksen, Jonas L ; Ghouse, Jonas ; Skov, Morten W ; Olesen, Morten S ; Holst, Anders G ; Pietersen, Adrian ; Nielsen, Jonas B ; Maier, Anja M. ; Graff, Claus ; Frikke-Schmidt, Ruth ; Kanters, Jørgen K. / Associations between primary care electrocardiography and non-Alzheimer dementia. I: Journal of Stroke & Cerebrovascular Diseases. 2022 ; Bind 31, Nr. 9.

Bibtex

@article{4227faec389146fd9d59bb75d7717ee7,
title = "Associations between primary care electrocardiography and non-Alzheimer dementia",
abstract = "OBJECTIVES: To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD.MATERIALS AND METHODS: We retrospectively included 170,605 primary care patients aged 60 years or older referred for an ECG by their general practitioner and followed them for a median of 7.6 years. Using Cox regression, we reported hazard ratios (HRs) for electrocardiogram markers. Subsequently, we evaluated if addition of these electrocardiogram markers to a clinical model improved risk prediction for non-AD using change in area under the receiver-operator characteristics curve (AUC).RESULTS: The 5-year cumulative incidence of non-AD was 3.4 %. Increased heart rate (HR=1.06 pr. 10 bpm [95% confidence interval: 1.04-1.08], p<0.001), shorter QRS duration (HR=1.07 pr. 10 ms [1.05-1.09], p<0.001), elevated J-amplitude (HR=1.16 pr. mm [1.08-1.24], p<0.001), decreased T-peak amplitude (HR=1.02 pr. mm [1.01-1.04], p=0.002), and increased QTc (HR=1.08 pr. 20 ms [1.05-1.10], p<0.001) were associated with an increased rate of non-AD. Atrial fibrillation on the ECG (HR=1.18 [1.08-1.28], p<0.001) Sokolow-Lyon index > 35 mm (HR=1.31 [1.18-1.46], p<0.001) and borderline (HR=1.18 [1.11-1.26], p<0.001) or abnormal (HR=1.40 [1.27-1.55], p<0.001) QRS-T angle were also associated with an increased rate of non-AD. Upon addition of ECG markers to the Cox model, 5-year and 10-year C-statistic (AUC) improved significantly (delta-AUC, 0.36 [0.18-0.50] and 0.20 [0.03-0.35] %-points, respectively).CONCLUSIONS: ECG markers typical of an elevated cardiovascular risk profile were associated with non-AD and improved both 5-year and 10-year risk predictions for non-AD.",
author = "Isaksen, {Jonas L} and Jonas Ghouse and Skov, {Morten W} and Olesen, {Morten S} and Holst, {Anders G} and Adrian Pietersen and Nielsen, {Jonas B} and Maier, {Anja M.} and Claus Graff and Ruth Frikke-Schmidt and Kanters, {J{\o}rgen K}",
note = "Copyright {\textcopyright} 2022 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2022",
month = jul,
day = "10",
doi = "10.1016/j.jstrokecerebrovasdis.2022.106640",
language = "English",
volume = "31",
journal = "Journal of Stroke & Cerebrovascular Diseases",
issn = "1052-3057",
publisher = "W.B.Saunders Co.",
number = "9",

}

RIS

TY - JOUR

T1 - Associations between primary care electrocardiography and non-Alzheimer dementia

AU - Isaksen, Jonas L

AU - Ghouse, Jonas

AU - Skov, Morten W

AU - Olesen, Morten S

AU - Holst, Anders G

AU - Pietersen, Adrian

AU - Nielsen, Jonas B

AU - Maier, Anja M.

AU - Graff, Claus

AU - Frikke-Schmidt, Ruth

AU - Kanters, Jørgen K

N1 - Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2022/7/10

Y1 - 2022/7/10

N2 - OBJECTIVES: To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD.MATERIALS AND METHODS: We retrospectively included 170,605 primary care patients aged 60 years or older referred for an ECG by their general practitioner and followed them for a median of 7.6 years. Using Cox regression, we reported hazard ratios (HRs) for electrocardiogram markers. Subsequently, we evaluated if addition of these electrocardiogram markers to a clinical model improved risk prediction for non-AD using change in area under the receiver-operator characteristics curve (AUC).RESULTS: The 5-year cumulative incidence of non-AD was 3.4 %. Increased heart rate (HR=1.06 pr. 10 bpm [95% confidence interval: 1.04-1.08], p<0.001), shorter QRS duration (HR=1.07 pr. 10 ms [1.05-1.09], p<0.001), elevated J-amplitude (HR=1.16 pr. mm [1.08-1.24], p<0.001), decreased T-peak amplitude (HR=1.02 pr. mm [1.01-1.04], p=0.002), and increased QTc (HR=1.08 pr. 20 ms [1.05-1.10], p<0.001) were associated with an increased rate of non-AD. Atrial fibrillation on the ECG (HR=1.18 [1.08-1.28], p<0.001) Sokolow-Lyon index > 35 mm (HR=1.31 [1.18-1.46], p<0.001) and borderline (HR=1.18 [1.11-1.26], p<0.001) or abnormal (HR=1.40 [1.27-1.55], p<0.001) QRS-T angle were also associated with an increased rate of non-AD. Upon addition of ECG markers to the Cox model, 5-year and 10-year C-statistic (AUC) improved significantly (delta-AUC, 0.36 [0.18-0.50] and 0.20 [0.03-0.35] %-points, respectively).CONCLUSIONS: ECG markers typical of an elevated cardiovascular risk profile were associated with non-AD and improved both 5-year and 10-year risk predictions for non-AD.

AB - OBJECTIVES: To determine whether electrocardiogram (ECG) markers are associated with incident non-Alzheimer's dementia (non-AD) and whether these markers also improve risk prediction for non-AD.MATERIALS AND METHODS: We retrospectively included 170,605 primary care patients aged 60 years or older referred for an ECG by their general practitioner and followed them for a median of 7.6 years. Using Cox regression, we reported hazard ratios (HRs) for electrocardiogram markers. Subsequently, we evaluated if addition of these electrocardiogram markers to a clinical model improved risk prediction for non-AD using change in area under the receiver-operator characteristics curve (AUC).RESULTS: The 5-year cumulative incidence of non-AD was 3.4 %. Increased heart rate (HR=1.06 pr. 10 bpm [95% confidence interval: 1.04-1.08], p<0.001), shorter QRS duration (HR=1.07 pr. 10 ms [1.05-1.09], p<0.001), elevated J-amplitude (HR=1.16 pr. mm [1.08-1.24], p<0.001), decreased T-peak amplitude (HR=1.02 pr. mm [1.01-1.04], p=0.002), and increased QTc (HR=1.08 pr. 20 ms [1.05-1.10], p<0.001) were associated with an increased rate of non-AD. Atrial fibrillation on the ECG (HR=1.18 [1.08-1.28], p<0.001) Sokolow-Lyon index > 35 mm (HR=1.31 [1.18-1.46], p<0.001) and borderline (HR=1.18 [1.11-1.26], p<0.001) or abnormal (HR=1.40 [1.27-1.55], p<0.001) QRS-T angle were also associated with an increased rate of non-AD. Upon addition of ECG markers to the Cox model, 5-year and 10-year C-statistic (AUC) improved significantly (delta-AUC, 0.36 [0.18-0.50] and 0.20 [0.03-0.35] %-points, respectively).CONCLUSIONS: ECG markers typical of an elevated cardiovascular risk profile were associated with non-AD and improved both 5-year and 10-year risk predictions for non-AD.

U2 - 10.1016/j.jstrokecerebrovasdis.2022.106640

DO - 10.1016/j.jstrokecerebrovasdis.2022.106640

M3 - Journal article

C2 - 35830834

VL - 31

JO - Journal of Stroke & Cerebrovascular Diseases

JF - Journal of Stroke & Cerebrovascular Diseases

SN - 1052-3057

IS - 9

M1 - 106640

ER -

ID: 314058172