TY - JOUR

T1 - Associations between postprandial gut hormones and markers of bone remodeling

AU - Jensen, Nina Wittorff

AU - Clemmensen, Kim Katrine Bjerring

AU - Jensen, Marie Møller

AU - Pedersen, Hanne

AU - Færch, Kristine

AU - Diaz, Lars Jorge

AU - Quist, Jonas Salling

AU - Størling, Joachim

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - Gut‐derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a random-ized, two‐day cross‐over study on 14 healthy individuals, we performed postprandial time‐course studies to examine the associations of the bone remodeling markers carboxyl‐terminal collagen type I crosslinks (CTX) and procollagen type 1 N‐terminal propeptide (P1NP) with the gut hormones glucose‐dependent insulinotropic polypeptide (GIP), glucagon‐like peptide 1 (GLP‐1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP‐1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP‐1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP‐1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP‐1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP‐1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.

AB - Gut‐derived hormones have been suggested to play a role in bone homeostasis following food intake, although the associations are highly complex and not fully understood. In a random-ized, two‐day cross‐over study on 14 healthy individuals, we performed postprandial time‐course studies to examine the associations of the bone remodeling markers carboxyl‐terminal collagen type I crosslinks (CTX) and procollagen type 1 N‐terminal propeptide (P1NP) with the gut hormones glucose‐dependent insulinotropic polypeptide (GIP), glucagon‐like peptide 1 (GLP‐1), and peptide YY (PYY) using two different meal types—a standardized mixed meal (498 kcal) or a granola bar (260 kcal). Plasma concentrations of total GIP, total GLP‐1, total PYY, CTX, and P1NP were measured up to 240 min after meal intake, and the incremental area under the curve (iAUC) for each marker was calculated. The iAUC of CTX and P1NP were used to assess associations with the iAUC of GIP, GLP‐1, and PYY in linear mixed effect models adjusted for meal type. CTX was positively associated with GIP and GLP‐1, and it was inversely associated with PYY (all p < 0.001). No associations of P1NP with GIP or GLP‐1 and PYY were found. In conclusion, the postprandial responses of the gut hormones GIP, GLP‐1, and PYY are associated with the bone resorption marker CTX, supporting a link between gut hormones and bone homeostasis following food intake.

KW - Bone markers

KW - Bone metabolism

KW - CTX

KW - Gut hormones

KW - P1NP

UR - http://www.scopus.com/inward/record.url?scp=85114840622&partnerID=8YFLogxK

U2 - 10.3390/nu13093197

DO - 10.3390/nu13093197

M3 - Journal article

C2 - 34579074

AN - SCOPUS:85114840622

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 9

M1 - 3197

ER -