TY - JOUR

T1 - Antimicrobial Peptides in Hidradenitis Suppurativa – A Systematic Review

AU - Yao, Y.

AU - Frew, J. W.

AU - Thomsen, S. F.

AU - Ring, Hans Christian

PY - 2022

Y1 - 2022

N2 - Hidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additionally, the reference lists of the included articles were screened and manually searched for relevant studies. The final literature sample is comprised of 18 retrospective and prospective studies (non-review and non-commentary) published between 2009 and 2020. This review demonstrates the multitude of AMPs in HS. Although the methodology of the studies may vary, the studies included indicate a consistent overexpression of hBD-2, S100A7, S100A8, and S100A9 at both mRNA and protein levels, and a decreased expression of hBD-1. Overall, the studies point to a dysregulation of AMPs in both lesional – and non-lesional HS skin.

AB - Hidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additionally, the reference lists of the included articles were screened and manually searched for relevant studies. The final literature sample is comprised of 18 retrospective and prospective studies (non-review and non-commentary) published between 2009 and 2020. This review demonstrates the multitude of AMPs in HS. Although the methodology of the studies may vary, the studies included indicate a consistent overexpression of hBD-2, S100A7, S100A8, and S100A9 at both mRNA and protein levels, and a decreased expression of hBD-1. Overall, the studies point to a dysregulation of AMPs in both lesional – and non-lesional HS skin.

U2 - 10.1111/bjd.20750

DO - 10.1111/bjd.20750

M3 - Review

C2 - 34498267

VL - 186

SP - 236

EP - 244

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 2

ER -