Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs

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Standard

Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs. / Rasmussen, Thomas; Follin, Bjarke; Kastrup, Jens; Brandt-Larsen, Malene; Madsen, Jacob; Emil Christensen, Thomas; Pharao Hammelev, Karsten; Hasbak, Philip; Kjær, Andreas.

I: Diagnostics, Bind 6, Nr. 2, 26, 17.06.2016.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Rasmussen, T, Follin, B, Kastrup, J, Brandt-Larsen, M, Madsen, J, Emil Christensen, T, Pharao Hammelev, K, Hasbak, P & Kjær, A 2016, 'Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs', Diagnostics, bind 6, nr. 2, 26. https://doi.org/10.3390/diagnostics6020026

APA

Rasmussen, T., Follin, B., Kastrup, J., Brandt-Larsen, M., Madsen, J., Emil Christensen, T., ... Kjær, A. (2016). Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs. Diagnostics, 6(2), [26]. https://doi.org/10.3390/diagnostics6020026

Vancouver

Rasmussen T, Follin B, Kastrup J, Brandt-Larsen M, Madsen J, Emil Christensen T o.a. Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs. Diagnostics. 2016 jun 17;6(2). 26. https://doi.org/10.3390/diagnostics6020026

Author

Rasmussen, Thomas ; Follin, Bjarke ; Kastrup, Jens ; Brandt-Larsen, Malene ; Madsen, Jacob ; Emil Christensen, Thomas ; Pharao Hammelev, Karsten ; Hasbak, Philip ; Kjær, Andreas. / Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs. I: Diagnostics. 2016 ; Bind 6, Nr. 2.

Bibtex

@article{a76883d5a12e47369b0aa4cb3f9bb57f,
title = "Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs",
abstract = "Angiogenesis is part of the healing process following an ischemic injury and is vital for the post-ischemic repair of the myocardium. Therefore, it is of particular interest to be able to noninvasively monitor angiogenesis. This might, not only permit risk stratification of patients following myocardial infarction, but could also facilitate development and improvement of new therapies directed towards stimulation of the angiogenic response. During angiogenesis endothelial cells must adhere to one another to form new microvessels. αvβ₃ integrin has been found to be highly expressed in activated endothelial cells and has been identified as a critical modulator of angiogenesis. (68)Ga-NODAGA-E[c(RGDyK)]₂ (RGD) has recently been developed by us as an angiogenesis positron-emission-tomography (PET) ligand targeted towards αvβ₃ integrin. In the present study, we induced myocardial infarction in G{\"o}ttingen minipigs. Successful infarction was documented by (82)Rubidium-dipyridamole stress PET and computed tomography. RGD uptake was demonstrated in the infarcted myocardium one week and one month after induction of infarction by RGD-PET. In conclusion, we demonstrated angiogenesis by noninvasive imaging using RGD-PET in minipigs hearts, which resemble human hearts. The perspectives are very intriguing and might permit the evaluation of new treatment strategies targeted towards increasing the angiogenetic response, e.g., stem-cell treatment.",
keywords = "Journal Article",
author = "Thomas Rasmussen and Bjarke Follin and Jens Kastrup and Malene Brandt-Larsen and Jacob Madsen and {Emil Christensen}, Thomas and {Pharao Hammelev}, Karsten and Philip Hasbak and Andreas Kj{\ae}r",
year = "2016",
month = "6",
day = "17",
doi = "10.3390/diagnostics6020026",
language = "English",
volume = "6",
journal = "Diagnostics",
issn = "2075-4418",
publisher = "MDPI AG",
number = "2",

}

RIS

TY - JOUR

T1 - Angiogenesis PET Tracer Uptake (68Ga-NODAGA-E[(cRGDyK)]₂) in Induced Myocardial Infarction in Minipigs

AU - Rasmussen, Thomas

AU - Follin, Bjarke

AU - Kastrup, Jens

AU - Brandt-Larsen, Malene

AU - Madsen, Jacob

AU - Emil Christensen, Thomas

AU - Pharao Hammelev, Karsten

AU - Hasbak, Philip

AU - Kjær, Andreas

PY - 2016/6/17

Y1 - 2016/6/17

N2 - Angiogenesis is part of the healing process following an ischemic injury and is vital for the post-ischemic repair of the myocardium. Therefore, it is of particular interest to be able to noninvasively monitor angiogenesis. This might, not only permit risk stratification of patients following myocardial infarction, but could also facilitate development and improvement of new therapies directed towards stimulation of the angiogenic response. During angiogenesis endothelial cells must adhere to one another to form new microvessels. αvβ₃ integrin has been found to be highly expressed in activated endothelial cells and has been identified as a critical modulator of angiogenesis. (68)Ga-NODAGA-E[c(RGDyK)]₂ (RGD) has recently been developed by us as an angiogenesis positron-emission-tomography (PET) ligand targeted towards αvβ₃ integrin. In the present study, we induced myocardial infarction in Göttingen minipigs. Successful infarction was documented by (82)Rubidium-dipyridamole stress PET and computed tomography. RGD uptake was demonstrated in the infarcted myocardium one week and one month after induction of infarction by RGD-PET. In conclusion, we demonstrated angiogenesis by noninvasive imaging using RGD-PET in minipigs hearts, which resemble human hearts. The perspectives are very intriguing and might permit the evaluation of new treatment strategies targeted towards increasing the angiogenetic response, e.g., stem-cell treatment.

AB - Angiogenesis is part of the healing process following an ischemic injury and is vital for the post-ischemic repair of the myocardium. Therefore, it is of particular interest to be able to noninvasively monitor angiogenesis. This might, not only permit risk stratification of patients following myocardial infarction, but could also facilitate development and improvement of new therapies directed towards stimulation of the angiogenic response. During angiogenesis endothelial cells must adhere to one another to form new microvessels. αvβ₃ integrin has been found to be highly expressed in activated endothelial cells and has been identified as a critical modulator of angiogenesis. (68)Ga-NODAGA-E[c(RGDyK)]₂ (RGD) has recently been developed by us as an angiogenesis positron-emission-tomography (PET) ligand targeted towards αvβ₃ integrin. In the present study, we induced myocardial infarction in Göttingen minipigs. Successful infarction was documented by (82)Rubidium-dipyridamole stress PET and computed tomography. RGD uptake was demonstrated in the infarcted myocardium one week and one month after induction of infarction by RGD-PET. In conclusion, we demonstrated angiogenesis by noninvasive imaging using RGD-PET in minipigs hearts, which resemble human hearts. The perspectives are very intriguing and might permit the evaluation of new treatment strategies targeted towards increasing the angiogenetic response, e.g., stem-cell treatment.

KW - Journal Article

U2 - 10.3390/diagnostics6020026

DO - 10.3390/diagnostics6020026

M3 - Journal article

C2 - 27322329

VL - 6

JO - Diagnostics

JF - Diagnostics

SN - 2075-4418

IS - 2

M1 - 26

ER -

ID: 164796309