Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt

Standard

Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity. / Bagger, Sofie Otzen; Hopkinson, Branden Michael; Pandey, Deo Prakash; Bak, Mads; Brydholm, Andreas Vincent; Villadsen, René; Helin, Kristian; Rønnov-Jessen, Lone; Petersen, Ole William; Kim, Jiyoung.

I: Molecular Cancer, Bind 17, Nr. 1, 171, 2018, s. 1-6.

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning › fagfællebedømt

Harvard

Bagger, SO, Hopkinson, BM, Pandey, DP, Bak, M, Brydholm, AV, Villadsen, R, Helin, K, Rønnov-Jessen, L, Petersen, OW & Kim, J 2018, 'Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity', Molecular Cancer, bind 17, nr. 1, 171, s. 1-6. https://doi.org/10.1186/s12943-018-0918-6

APA

Bagger, S. O., Hopkinson, B. M., Pandey, D. P., Bak, M., Brydholm, A. V., Villadsen, R., Helin, K., Rønnov-Jessen, L., Petersen, O. W., & Kim, J. (2018). Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity. Molecular Cancer, 17(1), 1-6. [171]. https://doi.org/10.1186/s12943-018-0918-6

Vancouver

Bagger SO, Hopkinson BM, Pandey DP, Bak M, Brydholm AV, Villadsen R o.a. Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity. Molecular Cancer. 2018;17(1):1-6. 171. https://doi.org/10.1186/s12943-018-0918-6

Author

Bagger, Sofie Otzen ; Hopkinson, Branden Michael ; Pandey, Deo Prakash ; Bak, Mads ; Brydholm, Andreas Vincent ; Villadsen, René ; Helin, Kristian ; Rønnov-Jessen, Lone ; Petersen, Ole William ; Kim, Jiyoung. / Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity. I: Molecular Cancer. 2018 ; Bind 17, Nr. 1. s. 1-6.

Bibtex

@article{962059df588049e8b41f481edd433fbb,
title = "Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity",
abstract = "Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigenesis of human breast cancer is not always restricted to typical EMT cells but is also somewhat paradoxically conveyed by subclones of apparently differentiated, non-EMT cells. Here we characterize such non-EMT-like and EMT-like subclones. Through a loss-of-function screen we found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis. These data command caution in attempts to assess tumorigenesis prospectively based on EMT profiling, and they emphasize the importance of next generation subtyping of tumors, that is at the level of clonal composition.",
keywords = "Breast cancer, shRNA screening, Collective migration, Non-EMT",
author = "Bagger, {Sofie Otzen} and Hopkinson, {Branden Michael} and Pandey, {Deo Prakash} and Mads Bak and Brydholm, {Andreas Vincent} and Ren{\'e} Villadsen and Kristian Helin and Lone R{\o}nnov-Jessen and Petersen, {Ole William} and Jiyoung Kim",
year = "2018",
doi = "10.1186/s12943-018-0918-6",
language = "English",
volume = "17",
pages = "1--6",
journal = "Molecular Cancer",
issn = "1476-4598",
publisher = "BioMed Central",
number = "1",

}

RIS

TY - JOUR

T1 - Aggressiveness of non-EMT breast cancer cells relies on FBXO11 activity

AU - Bagger, Sofie Otzen

AU - Hopkinson, Branden Michael

AU - Pandey, Deo Prakash

AU - Bak, Mads

AU - Brydholm, Andreas Vincent

AU - Villadsen, René

AU - Helin, Kristian

AU - Rønnov-Jessen, Lone

AU - Petersen, Ole William

AU - Kim, Jiyoung

PY - 2018

Y1 - 2018

N2 - Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigenesis of human breast cancer is not always restricted to typical EMT cells but is also somewhat paradoxically conveyed by subclones of apparently differentiated, non-EMT cells. Here we characterize such non-EMT-like and EMT-like subclones. Through a loss-of-function screen we found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis. These data command caution in attempts to assess tumorigenesis prospectively based on EMT profiling, and they emphasize the importance of next generation subtyping of tumors, that is at the level of clonal composition.

AB - Tumorigenesis is increasingly considered to rely on subclones of cells poised to undergo an epithelial to mesenchymal transition (EMT) program. We and others have provided evidence, however, that the tumorigenesis of human breast cancer is not always restricted to typical EMT cells but is also somewhat paradoxically conveyed by subclones of apparently differentiated, non-EMT cells. Here we characterize such non-EMT-like and EMT-like subclones. Through a loss-of-function screen we found that a member of the E3 ubiquitin ligase complexes, FBXO11, specifically fuels tumor formation of a non-EMT-like clone by restraining the p53/p21 pathway. Interestingly, in the related EMT-like clone, FBXO11 operates through the BCL2 pathway with little or no impact on tumorigenesis. These data command caution in attempts to assess tumorigenesis prospectively based on EMT profiling, and they emphasize the importance of next generation subtyping of tumors, that is at the level of clonal composition.

KW - Breast cancer

KW - shRNA screening

KW - Collective migration

KW - Non-EMT

U2 - 10.1186/s12943-018-0918-6

DO - 10.1186/s12943-018-0918-6

M3 - Comment/debate

C2 - 30526604

VL - 17

SP - 1

EP - 6

JO - Molecular Cancer

JF - Molecular Cancer

SN - 1476-4598

IS - 1

M1 - 171

ER -

ID: 210195701