A method for assessment of the dynamic response of the arterial baroreflex

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A method for assessment of the dynamic response of the arterial baroreflex. / Lund, Morten T; Salomonsson, Max; Jonassen, Thomas E N; Holstein-Rathlou, Niels-Henrik.

I: Acta Physiologica (Print), Bind 222, Nr. 2, e12962 , 02.2018.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lund, MT, Salomonsson, M, Jonassen, TEN & Holstein-Rathlou, N-H 2018, 'A method for assessment of the dynamic response of the arterial baroreflex', Acta Physiologica (Print), bind 222, nr. 2, e12962 . https://doi.org/10.1111/apha.12962

APA

Lund, M. T., Salomonsson, M., Jonassen, T. E. N., & Holstein-Rathlou, N-H. (2018). A method for assessment of the dynamic response of the arterial baroreflex. Acta Physiologica (Print), 222(2), [e12962 ]. https://doi.org/10.1111/apha.12962

Vancouver

Lund MT, Salomonsson M, Jonassen TEN, Holstein-Rathlou N-H. A method for assessment of the dynamic response of the arterial baroreflex. Acta Physiologica (Print). 2018 feb.;222(2). e12962 . https://doi.org/10.1111/apha.12962

Author

Lund, Morten T ; Salomonsson, Max ; Jonassen, Thomas E N ; Holstein-Rathlou, Niels-Henrik. / A method for assessment of the dynamic response of the arterial baroreflex. I: Acta Physiologica (Print). 2018 ; Bind 222, Nr. 2.

Bibtex

@article{0ca7d48b4b1642bba84dddfd511f4cf5,

title = "A method for assessment of the dynamic response of the arterial baroreflex",

abstract = "AIM: The baroreflex is a key mechanism in cardiovascular regulation and alterations in baroreceptor function are seen in many diseases, including heart failure, obesity and hypertension. We propose a new method for analyzing baroreceptor function from continuous blood pressure and heart rate in both health and disease.METHODS: 48-hour data series of blood pressure and heart rate were collected with telemetry. Sprague-Dawley rats on standard chow (n=11) served as controls, while rats on a high-fat, high-fructose diet (n=6) constituted the obese-hypertensive model. A third group of rats underwent autonomic blockade (n=6). An autoregressive-moving-average with exogenous inputs (ARMAX)-model was applied to the data and compared with the α-coefficient.RESULTS: Autonomic blockade caused a significant reduction in the strength of the baroreflex as estimated by ARMAX (ARMAX-BRS -0.03±0.01 vs. -0.19±0.04 bpm heartbeat-1). Both methods showed a ~50% reduction in BRS in the obese-hypertensive group compared with control (body weight 531±27 vs. 458±19 g, p<0.05; mean arterial pressure 119±3 vs. 102±1 mmHg, p<0.05; ARMAX-BRS -0.08±0.01 vs. -0.15±0.01 bpm heartbeat-1, p<0.05; α-coefficient-BRS 0.51±0.07 vs. 0.89±0.07 ms mmHg-1, p<0.05). The ARMAX-method additionally showed the open-loop-gain of the baroreflex to be reduced by ~50% in the obese-hypertensive group (-2.3±0.3 vs. -4.1±0.3 bpm, p<0.05), while the rate constant was similar between groups.CONCLUSION: The ARMAX-model represents an efficient method for estimating several aspects of the baroreflex. The open-loop-gain of the baroreflex was attenuated in obese-hypertensive rats compared with control, while the time response was similar. The algorithm can be applied to other species including humans. This article is protected by copyright. All rights reserved.",

keywords = "Journal Article",

author = "Lund, {Morten T} and Max Salomonsson and Jonassen, {Thomas E N} and Niels-Henrik Holstein-Rathlou",

year = "2018",

month = feb,

doi = "10.1111/apha.12962",

language = "English",

volume = "222",

journal = "Acta Physiologica",

issn = "1748-1708",

publisher = "Wiley-Blackwell",

number = "2",

}

RIS

TY - JOUR

T1 - A method for assessment of the dynamic response of the arterial baroreflex

AU - Lund, Morten T

AU - Salomonsson, Max

AU - Jonassen, Thomas E N

AU - Holstein-Rathlou, Niels-Henrik

PY - 2018/2

Y1 - 2018/2

N2 - AIM: The baroreflex is a key mechanism in cardiovascular regulation and alterations in baroreceptor function are seen in many diseases, including heart failure, obesity and hypertension. We propose a new method for analyzing baroreceptor function from continuous blood pressure and heart rate in both health and disease.METHODS: 48-hour data series of blood pressure and heart rate were collected with telemetry. Sprague-Dawley rats on standard chow (n=11) served as controls, while rats on a high-fat, high-fructose diet (n=6) constituted the obese-hypertensive model. A third group of rats underwent autonomic blockade (n=6). An autoregressive-moving-average with exogenous inputs (ARMAX)-model was applied to the data and compared with the α-coefficient.RESULTS: Autonomic blockade caused a significant reduction in the strength of the baroreflex as estimated by ARMAX (ARMAX-BRS -0.03±0.01 vs. -0.19±0.04 bpm heartbeat-1). Both methods showed a ~50% reduction in BRS in the obese-hypertensive group compared with control (body weight 531±27 vs. 458±19 g, p<0.05; mean arterial pressure 119±3 vs. 102±1 mmHg, p<0.05; ARMAX-BRS -0.08±0.01 vs. -0.15±0.01 bpm heartbeat-1, p<0.05; α-coefficient-BRS 0.51±0.07 vs. 0.89±0.07 ms mmHg-1, p<0.05). The ARMAX-method additionally showed the open-loop-gain of the baroreflex to be reduced by ~50% in the obese-hypertensive group (-2.3±0.3 vs. -4.1±0.3 bpm, p<0.05), while the rate constant was similar between groups.CONCLUSION: The ARMAX-model represents an efficient method for estimating several aspects of the baroreflex. The open-loop-gain of the baroreflex was attenuated in obese-hypertensive rats compared with control, while the time response was similar. The algorithm can be applied to other species including humans. This article is protected by copyright. All rights reserved.

AB - AIM: The baroreflex is a key mechanism in cardiovascular regulation and alterations in baroreceptor function are seen in many diseases, including heart failure, obesity and hypertension. We propose a new method for analyzing baroreceptor function from continuous blood pressure and heart rate in both health and disease.METHODS: 48-hour data series of blood pressure and heart rate were collected with telemetry. Sprague-Dawley rats on standard chow (n=11) served as controls, while rats on a high-fat, high-fructose diet (n=6) constituted the obese-hypertensive model. A third group of rats underwent autonomic blockade (n=6). An autoregressive-moving-average with exogenous inputs (ARMAX)-model was applied to the data and compared with the α-coefficient.RESULTS: Autonomic blockade caused a significant reduction in the strength of the baroreflex as estimated by ARMAX (ARMAX-BRS -0.03±0.01 vs. -0.19±0.04 bpm heartbeat-1). Both methods showed a ~50% reduction in BRS in the obese-hypertensive group compared with control (body weight 531±27 vs. 458±19 g, p<0.05; mean arterial pressure 119±3 vs. 102±1 mmHg, p<0.05; ARMAX-BRS -0.08±0.01 vs. -0.15±0.01 bpm heartbeat-1, p<0.05; α-coefficient-BRS 0.51±0.07 vs. 0.89±0.07 ms mmHg-1, p<0.05). The ARMAX-method additionally showed the open-loop-gain of the baroreflex to be reduced by ~50% in the obese-hypertensive group (-2.3±0.3 vs. -4.1±0.3 bpm, p<0.05), while the rate constant was similar between groups.CONCLUSION: The ARMAX-model represents an efficient method for estimating several aspects of the baroreflex. The open-loop-gain of the baroreflex was attenuated in obese-hypertensive rats compared with control, while the time response was similar. The algorithm can be applied to other species including humans. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1111/apha.12962

DO - 10.1111/apha.12962

M3 - Journal article

C2 - 28872781

VL - 222

JO - Acta Physiologica

JF - Acta Physiologica

SN - 1748-1708

IS - 2

M1 - e12962

ER -

ID: 183469692

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