Michael J. Davies

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Sprogkundskaber

Prof. Davies' research interests lie in the mechanisms of protein modification by reactive species (radicals, two-electron oxidants, glycation reactions), the biological consequences of such reactions, and the development of methods to quantify protein damage in disease with a particular emphasis on cardiovascular pathologies.

He has interests in peroxidase enzymes (particularly myeloperoxidase), LC-MS (proteomic) detection, identification, characterization and quantification of protein modifications, EPR spectroscopy for the detection of transient radicals, the kinetics of oxidant reactions, extracellular matrix damage and the development of antioxidants and inhibitors of oxidant formation.

Current projects:

• Oxidation- and glycation-induced changes in protein structure and function
• Extracellular matrix damage and atherosclerosis
• Kinetics and mechanisms of oxidative damage to proteins induced by hypochlorous acid, peroxynitrous acid, singlet oxygen, peroxides, sugars and metal ions
• Myeloperoxidase, inflammation and cardiovascular disease
• Novel selenium- and sulphur-based antioxidants
• Characterization, detection and quantification of protein modifications by LC-MS proteomics at the level of amino acids, peptides and proteins   

Career

1978-1981   BSc (1st Class Honours),University of York, UK

1981-1984   D.Phil., University of York, UK

1984-1987   Post-doctoral fellow, Brunel University, UK

1987-1995   Lecturer, University of York, UK

1995-2001   Group Leader, The Heart Research Institute, Sydney, Australia

1995-2000   Australian Research Council QE2 Fellowship

2000-2004   Australian Research Council Senior Research Fellow

2001-2012   Deputy Director, The Heart Research Institute, Sydney, Australia

2009-2013   Australian Research Council Professorial Fellow

2012-2014   Director, The Heart Research Institute, Sydney, Australia

2014-            Professor of Oxidative Biology of Proteins, Copenhagen University

Prizes and Awards       

Society for Free Radical Research - Europe, Lectureship and Award, 2017;

Lifetime Achievement Award, Society for Free Radical Research-India, 2014;

Informa Lecturer, SFRR-Asia 2013;

Distinguished Service Award, Society for Free Radical Research-Australia (2012);

Distinguished Service Award, Asia-Pacific EPR Society (2008);

Piette Memorial Lecture, 49^th Rocky Mountain Analytical Conference (2007);

John Wilberforce Lothian Award for research excellence, National Heart Foundation (2007);

Archibald Olle Prize of the Royal Australian Chemical Institute (2006);

Aniko Whealy Research Award of the National Heart Foundation (2004);

Silver Medal of the International EPR Society (2003);

Chartered Chemist;

Fellow of the Royal Australian Chemical Institute. 

Fellow of the Royal Society of Chemistry, UK

Scientific Committees

President, Society for Free Radical Research Europe (2019-2020)

President-Elect, Society for Free Radical Research Europe (2017-2018)

President, Society for Free Radical Research – International (2013-2014)

President-Elect, Society for Free Radical Research – International (2011-2012)

Vice-President, International EPR Society (2008-2011)

Secretary-General, International Society for Free Radical Research (2007-2010)

Council member, American Society for Photobiology (2005-2008)

President, Society for Free Radical Research (Australasia) (2001-2003)

Secretary, Mutagenesis and Experimental Pathology Society Australasia (2003-2006)

Council member, Mutagenesis and Experimental Pathology Society Australasia (2002-2006)

Committee member, International Society for Free Radical Research (2001-present)

President-Elect, Society for Free Radical Research (Australasia) (1999-2001)

Vice-Chairperson, Sydney Free Radical Group (1998-2001)

Biochemical Society, Harden Conference Committee (1993-1995)

Royal Society of Chemistry, ESR Group Committee (1992-1995)

Society for Free Radical Research, European Committee (1992-1994)

Editorial Responsibilities                  

Editor-in-Chief: “Free Radical Research” (2009-2018)

Editor: “Biochemical Journal” (2009-present)

Associate Editor: “Photochemistry and Photobiology” (2009-present)

Editor: Royal Society of Chemistry, ESR/EPR Specialist Periodical Reports (1993-2008, vols. 14-21).

Editorial Boards: Biochemical Journal (2009-); Chemical Research in Toxicology (2003-2005); Free Radical Biology and Medicine (2000-); Free Radical Research (2000-); Redox Report (1994-); Spectroscopy (2001-2012); Royal Society of Chemistry (UK) Specialist Periodical Reports (1994 - 2008); Journal of Clinical Biochemistry and Nutrition (2006-); Biomedical Spectroscopy and Imaging (2012-present); Redox Biology (2013-), Antioxidants (2016-), BioFactors (2019-present), Advances in Redox Research (2020-), Acta Biochimica Polonica (2021-).

‘Scientific standards and Ethics’ editor for ‘Redox Biology’, ‘Advances in Redox Research’ and ‘Redox in Muscle Physiology, Exercise and Sport’ (2022-).

Recent Plenary and Invited Lectures (last 5 years only)

2 Gordon Conferences, USA (x 4), Italy (x 3) and Turkey (x 3), Japan (x 3), UK (x 3), India (x 3), Spain, Taiwan, China, Denmark, Poland (x 2), Greece, France, Canada, Malaysia, Puerto Rico and Belgium.

Conference Organisation (last 5 years only)

Co-Chair: Gordon Conference on Oxygen Radicals (2018)

Co-Chair: 10th Human Peroxidase meeting (2018)

Vice-Chair: Gordon Conference on Oxygen Radicals (2016)

Chair: Asia-Pacific EPR Society meeting (2008);

Chair: 8th International Human Peroxidase meeting (2013);

Chair: 6th JointMeetingofthe SocietiesforFree Radical Research Australasia and Japan (2013).

International Scientific Program Committees: SFRR-Australasia/SFRR-Japan/MEPSA /ASCEPT meeting, 2009; Soc. Free Radical Research-India, India, 2010; EPR 2010, Puerto Rico; 15^th Congress Intl. Soc. for Free Radical Research, USA, 2010; Spin 2011, France; Intl. Conf. on Free Radicals, Antioxidants and Nutraceuticals, India, 2012; 16^th Intl. Soc. for Free Radical Research, UK, 2012; SFRR–Europe, Greece, 2013; AOCP, 2013; SFRR-Europe, 2014; 16^th Amine Oxidase Conference, 2014; Spin, 2014.

Supervisory and Management Experience       

Director, Seleno Therapeutics Ltd

Senior Scientific Advisor: EU International Training Network: MASSTRPLAN (MASS spectrometry TRaining in Protein Lipoxidation ANalysis for Inflammation).

Management Committee member: EU COST Action CA16116 (NutRedOx) and EU COST Action CM1001 (Biomimetic Chemistry)

International member: EU COST Action CM1201 (Post translational modification of proteins)

Director and Deputy Director of Heart Research Institute, Sydney, Australia;

Chair - Biomedical Science and Biotechnology Grant Committee for Australian Institute of Nuclear Science and Engineering;  Management committee of Australian Research Council Centre of Excellence.

Supervision of 45 PhD students to successful completion. Mentored 29 post-doctoral researchers.

Bibliometrics                  

Prof. Davies has published 368 peer-reviewed journal articles, 1 book, 8 edited volumes, 26 book chapters and 8 patents. His work has been cited ~ 22,000 times as of September 2019 (ISI Web of Science). He has an h-index of 71 (ISI Web of Science) and an m-index (h index divided by number of years since first paper published) of ~2. His work is currently attracting > 1000 citations per year and he averages > 60 citations per paper.