Jens Høiriis Nielsen
Emeritus
Introductory remarks on publicationslist
153 scientific publications including 96 original papers, 3 patent applications and 54 reviews book chapters and conference proceedings. In addition app. abstracts and >250 invited lectures.
- 2024
- Published
Proinflammatory cytokines suppress nonsense-mediated RNA decay to impair regulated transcript isoform processing in pancreatic β cells
Ghiasi, S. M., Marchetti, P., Piemonti, L., Nielsen, Jens Høiriis, Porse, Bo Torben, Mandrup-Poulsen, Thomas & Rutter, G. A., 2024, In: Frontiers in Endocrinology. 15, 13 p., 1359147.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
High-Intensity Interval Training Improves Cardiac Function by miR-206 Dependent HSP60 Induction in Diabetic Rats
Delfan, M., Amadeh Juybari, R., Gorgani-Firuzjaee, S., Nielsen, Jens Høiriis, Delfan, N., Laher, I., Saeidi, A., Granacher, U. & Zouhal, H., 2022, In: Frontiers in Cardiovascular Medicine. 9, 11 p., 927956.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Fetal Programming of the Endocrine Pancreas: Impact of a Maternal Low-Protein Diet on Gene Expression in the Perinatal Rat Pancreas
Winkel, L., Rasmussen, Morten Arendt, Larsen, L., Dalgaard, L. T. & Nielsen, Jens Høiriis, 2022, In: International Journal of Molecular Sciences. 23, 19, 21 p., 11057.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Regulation of integrin alpha 6A by lactogenic hormones in rat pancreatic beta-cells: Implications for the physiological adaptation to pregnancy
Moldrup, A., Lindberg, M. N., Galsgaard, E. D., Henriksen, U., Dalgaard, L. T. & Nielsen, Jens Høiriis, 2020, In: Acta Physiologica. 229, 3, 13 p., 13454.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Possible mechanisms involved in improved beta cell function in pregnant women with type 1 diabetes
Nalla, A., Ringholm, L., Sorensen, S. N., Damm, Peter, Mathiesen, Elisabeth & Nielsen, Jens Høiriis, 2020, In: Heliyon. 6, 8, 6 p., 04569.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Localization of microRNA-375 in perinatal rat pancreas
Larsen, L., Rosenstierne, M. W., Nielsen, Jens Høiriis & Dalgaard, L. T., 2018, In: Non-Coding RNAs in Endocrinology. 3, p. 1-4Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trefoil factor 3 in perinatal pancreas is increased by gestational low protein diet and associated with accelerated beta-cell maturation
Winkel, L., Bagge, A., Larsen, L., Haase, T. N., Rasmussen, M., Lykke, J., Holmgaard, D. B., Thim, L., Nielsen, Jens Høiriis & Dalgaard, L. T., 2018, In: Islets. 10, 3, p. 124–135Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Impact of maternal obesity and diabetes on fetal pancreatic development
Nielsen, Jens Høiriis, Jaksch, C. A. M., Lessi, I. & Damasceno, D. C., Jun 2017, Fetal and Early Postnatal Programming and its Influence on Adult Health. Boca Raton: CRC Press, p. 125-140 16 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2016
- Published
Research Resource: A Dual Proteomic Approach Identifies Regulated Islet Proteins During β-Cell Mass Expansion In Vivo
Horn, S., Kirkegaard, J. S., Hoelper, S., Seymour, Philip Allan, Rescan, C., Nielsen, Jens Høiriis, Madsen, O. D., Jensen, J. N., Kruger, M., Gronborg, M. & Ahnfelt-Rønne, J., 2016, In: Molecular endocrinology (Baltimore, Md.). 30, 1, p. 133-143 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Diabetes on Circulating Pancreatic Hormones in Pregnant Rats and Their Offspring
Iessi, I. L., Sinzato, Y. K., Gallego, F. Q., Nielsen, Jens Høiriis & Damasceno, D. C., Sep 2016, In: Hormone and Metabolic Research. 48, 10, p. 682-686 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta cell adaptation in pregnancy: a tribute to Claes Hellerström
Nielsen, Jens Høiriis, May 2016, In: Upsala Journal of Medical Sciences. 121, 2, p. 151-154 4 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
β-Cell Adaptability during Pregnancy
Nielsen, Jens Høiriis, Horn, S., Kirkegaard, J. S., Nalla, A. & Søstrup, B., 2016, Control of Pancreatic Beta Cell Function and Plasticity in Health and Diabetes. Bentham Science Publishers, p. 123-168 45 p. (Current and Future Developments in Physiology, Vol. 1).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2014
- Published
CTSH regulates β-cell function and disease progression in newly diagnosed type 1 diabetes patients
Fløyel, T., Brorsson, C., Nielsen, L. B., Miani, M., Bang-Berthelsen, C. H., Friedrichsen, M., Overgaard, A. J., Berchtold, L. A., Wiberg, A., Poulsen, P., Hansen, L., Rosinger, S., Boehm, B. O., Ram, R., Nguyen, Q., Mehta, M., Morahan, G., Concannon, P., Bergholdt, R., Nielsen, J. H. & 7 others, , 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. 10305-10310 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The mitogenic effect of Gas6 on pancreatic beta cells is mediated via the receptor tyrosine kinase Axl
Haase, T. N., Gustafsson, A., Nalla, A., Ringholm, L., Damm, Peter, Mathiesen, Elisabeth, Dahlback, B., Billestrup, Nils & Nielsen, Jens Høiriis, Sep 2014, In: Diabetologia. 57, 1 Suppl, p. S173-S174 408.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model
Kongsted, A. H., Tygesen, M. P., Husted, S. V., Oliver, M. H., Tolver, Anders, Christensen, V. G., Nielsen, Jens Høiriis & Nielsen, M. O., 2014, In: Acta Physiologica (Print). 210, 1, p. 84-98 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional characteristics of neonatal rat β cells with distinct markers
Martens, G. A., Motté, E., Kramer, G., Stangé, G., Gaarn, L. W., Hellemans, K., Nielsen, Jens Høiriis, Aerts, J. M., Ling, Z. & Pipeleers, D., Feb 2014, In: Journal of Molecular Endocrinology. 52, 1, p. 11-28 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Implications for the offspring of circulating factors involved in beta cell adaptation in pregnancy
Nalla, A., Ringholm, L., Søstrup, B., Højrup, P., Thim, L., Levery, S. B., Vakhrushev, Sergey, Billestrup, Nils, Mathiesen, Elisabeth, Damm, Peter & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1181-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of fetal and neonatal environment on beta cell function and development of diabetes
Nielsen, Jens Høiriis, Haase, T. N., Jaksch, C., Nalla, A., Søstrup, B., Nalla, A. A., Larsen, L., Rasmussen, M., Dalgaard, L. T., Gaarn, L. W., Thams, P., Kofod, H. & Billestrup, Nils, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1109-22 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Co-ordinated regulation of neurogenin-3 expression in the maternal and fetal pancreas during pregnancy
Søstrup, B., Gaarn, L. W., Nalla, A., Billestrup, Nils & Nielsen, Jens Høiriis, Nov 2014, In: Acta Obstetricia et Gynecologica Scandinavica. 93, 11, p. 1190-7 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Growth arrest specific protein (GAS) 6: a role in the regulation of proliferation and functional capacity of the perinatal rat beta cell
Haase, T. N., Rasmussen, M., Jaksch, C. A. M., Gaarn, L. W., Petersen, C. K., Billestrup, Nils & Nielsen, Jens Høiriis, Apr 2013, In: Diabetologia. 56, 4, p. 763-773 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta Cell Workshop 2013 Kyoto
Heller, R. S., Madsen, O. D. & Nielsen, Jens Høiriis, 11 Jun 2013, In: Islets. 5, 3, p. 107-110 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
MicroRNA-29a is up-regulated in beta-cells by glucose and decreases glucose-stimulated insulin secretion
Bagge, A., Clausen, T. R., Larsen, S., Ladefoged, M., Rosenstierne, M. W., Larsen, L., Vang, O., Nielsen, Jens Høiriis & Dalgaard, L. T., 21 Sep 2012, In: Biochemical and Biophysical Research Communications. 426, 2, p. 266-72 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Workshop on programming beta cell development, impairment and regeneration
Heller, S. & Nielsen, Jens Høiriis, 2012, In: Islets. 4, 2, p. 119-22 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
- Published
Suppression of FAT/CD36 mRNA by human growth hormone in pancreatic ß-cells
Dalgaard, L. T., Thams, P. G., Gaarn, L. W., Jensen, J., Lee, Y. C. & Nielsen, Jens Høiriis, 1 Jul 2011, In: Biochemical and Biophysical Research Communications. 410, 2, p. 345-350 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression and Localization of microRNAs in Perinatal Rat Pancreas: Role of miR-21 in Regulation of Cholesterol Metabolism
Larsen, L., Rosenstierne, M. W., Gaarn, L. W., Bagge, A., Pedersen, L., Dahmcke, C. M., Nielsen, Jens Høiriis & Dalgaard, L. T., 11 Oct 2011, In: PLOS ONE. 6, 10, p. e25997 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
AKAP 18 a and g have opposing effects on insulin release in INS 1E cells
Nielsen, Jens Høiriis, Lee, Y. C. & Thams, P. G., 2010, In: FEBS Letter. 584, p. 81-85Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Expression profiling of human genetic and protein interaction networks in type 1 diabetes
Bergholdt, R., Brorsson, C., Lage, K., Nielsen, Jens Høiriis, Brunak, S. & Pociot, Flemming, 2009, In: PLoS ONE. 4, 7, p. e6250Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CXCL12/SDF-1 over-expression in human insulinomas and its biological relevance
Ilhan, A., Nabokikh, A., Maj, M., Vidakovic, M., Nielsen, Jens Høiriis, Prikoszovich, T., Niederle, B., Base, W., Luger, A. & Wagner, L., 2009, In: Molecular and Cellular Endocrinology. 298, 1-2, p. 1-10 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
- Published
STAT5 activity in pancreatic beta cells.
Dalgaard, L. T., Billestrup, N. & Nielsen, Jens Høiriis, 2008, In: Expert Review of Endocrinology & Metabolism. 3, 4, p. 423-439 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of beta cell replication.
Lee, Y. C. & Nielsen, Jens Høiriis, 2008, In: Molecular and Cellular Endocrinology.Research output: Contribution to journal › Journal article › Research › peer-review
- 2007
- Published
Transcriptional profiling of type 1 diabetes genes on chromosome 21 in a rat beta-cell line and human pancreatic islets
Bergholdt, R., Karlsen, A. E., Hagedorn, P. H., Aalund, M., Nielsen, Jens Høiriis, Kruhoffer, M., Orntoft, T., Wang, H., Wollheim, C. B., Nerup, J. & Pociot, Flemming, 2007, In: Genes and Immunity. 8, 3, p. 232-238 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Remarkable heterogeneity displayed by oval cells in rat and mouse models of stem cell-mediated liver regeneration.
Jelnes, P., Santoni-Rugiu, E., Rasmussen, M., Friis, S. L., Nielsen, Jens Høiriis, Tygstrup, N. & Bisgaard, Hanne Cathrine, 2007, In: Hepatology. 45, 6, p. 1462-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reduced TGF-beta1 expression and its target genes in human insulinomas
Nabokikh, A., Ilhan, A., Bilban, M., Gartner, W., Vila, G., Niederle, B., Nielsen, Jens Høiriis, Wagner, O., Base, W., Luger, A. & Wagner, L., 2007, In: Experimental and Clinical Endocrinology and Diabetes. 115, 10, p. 674-682 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2006
- Published
Stimulation of pancreatic beta-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways.
Friedrichsen, B. N., Neubauer, N., Lee, Y. C., Gram, V. K., Blume, N., Petersen, J. S., Nielsen, Jens Høiriis & Møldrup, A., 2006, In: Journal of Endocrinology. 188, 3, p. 481-92 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
STAT5 activity in pancreatic beta-cells influences the severity of diabetes in animal models of type 1 and 2 diabetes.
Jackerott, M., Møldrup, A., Thams, P., Galsgaard, E. D., Knudsen, J., Lee, Y. C. & Nielsen, Jens Høiriis, 2006, In: Diabetes. 55, 10, p. 2705-12 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Trefoil factors are expressed in human and rat endocrine pancreas: differential regulation by growth hormone.
Jackerott, M., Lee, Y. C., Møllgård, Kjeld, Kofod, H., Jensen, J., Rohleder, S., Neubauer, N., Gaarn, L. W., Lykke, J., Dodge, R., Dalgaard, L. T., Søstrup, B., Jensen, D. B., Thim, L., Nexø, E., Thams, P., Bisgaard, Hanne Cathrine & Nielsen, Jens Høiriis, 2006, In: Endocrinology. 147, 12, p. 5752-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytokine signalling in embryonic stem cells.
Kristensen, D. M., Kalisz, M. & Nielsen, Jens Høiriis, 2006, In: Acta Pathologica Microbiologica et Immunologica Scandinavica. 113, 11-12, p. 756-72 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2005
- Published
STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferon-gamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production.
Jensen, J., Galsgaard, E. D., Karlsen, A. E., Lee, Y. C. & Nielsen, Jens Høiriis, 2005, In: Journal of Endocrinology. 187, 1, p. 25-36 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2004
- Published
Development and Life Cycle of a β-Cell
Serup, P. & Nielsen, Jens Høiriis, 2004, International Textbook of Diabetes Mellitus, Third Edition. Chichester: IEEE Computer Society Press, p. 59-78Research output: Chapter in Book/Report/Conference proceeding › Report chapter › Research
- 2003
- Published
Expression, biosynthesis and release of preadipocyte factor-1/ delta-like protein/fetal antigen-1 in pancreatic beta-cells: possible physiological implications
Friedrichsen, B. N., Carlsson, C., Møldrup, A., Michelsen, B., Jensen, C. H., Teisner, B. & Nielsen, Jens Høiriis, Feb 2003, In: Journal of Endocrinology. 176, 2, p. 257-66 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells
Friedrichsen, B. N., Richter, H. E., Hansen, J. A., Rhodes, C. J., Nielsen, Jens Høiriis, Billestrup, Nils & Møldrup, A., May 2003, In: Molecular endocrinology (Baltimore, Md.). 17, 5, p. 945-58 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2001
- Published
Expression of SMAD signal transduction molecules in the pancreas
Brorson, M., Hougaard, D., Nielsen, Jens Høiriis, Tornehave, D. & Larsson, L., 2001, In: Histochemistry and Cell Biology. 116, 3, p. 263-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth hormone - and prolactin- induced proliferation of insulinoma cells, INS-1, depends on activation of STAT5 (signal transducer and activator of transcription 5)
Friedrichsen, B. N., Galsgaard, E. D., Nielsen, Jens Høiriis & Møldrup, A., 2001, In: Molecular Endocrinology. 15, p. 136-148Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells
Galsgaard, E. D., Friedrichsen, B. N., Møldrup, A. & Nielsen, Jens Høiriis, 2001, In: Diabetes. 50 Suppl 1, Vol.50, Suppl.1, p. 40-41Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Suppressor of cytokine signaling 3 (SOCS-3) protects ß-cells against interleukin-1ß- and interferon-¿- mediated toxicity
Karlsen, A. E., Rønn, S. G., Lindberg, K., Jonannesen, J., Galsgaard, E. D., Pociot, F., Nielsen, Jens Høiriis, Mandrup-Poulsen, T. R., Nerup, J. & Billestrup, N., 2001, In: Proceedings of the National Academy of Science of the United States of America. Vol.98, p. 12191-12196Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of ß-cell mass by hormones and growth factors
Nielsen, Jens Høiriis, Galsgaard, E. D., Møldrup, A., Friedrichsen, B. N., Billestrup, N., Hansen, J. A., Lee, Y. C. & Carlson, C., 2001, In: Diabetes. Vol.50. Suppl.1, p. 25-29Research output: Contribution to journal › Journal article › Research › peer-review
- 1999
- Published
Regulation of prolactin receptor (PRLR) gene expression in insulin-producing cells. Prolactin and growth hormone activate one of the rat prlr gene promoters via STAT5a and STAT5b
Galsgaard, E. D., Møldrup, A. & Nielsen, Jens Høiriis, 25 Jun 1999, In: The Journal of Biological Chemistry. 274, 26, p. 18686-92 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, Jens Høiriis & Billestrup, Nils, Nov 1999, In: Molecular endocrinology (Baltimore, Md.). 13, 11, p. 1832-43 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Developmental expression of proprotein convertase 1/3 in the rat
Lee, Y. C., Damholt, A. B., Billestrup, Nils, Kisbye, T., Galante, P., Michelsen, B., Kofod, H. & Nielsen, Jens Høiriis, 10 Sep 1999, In: Molecular and Cellular Endocrinology. 155, 1-2, p. 27-35 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta cell proliferation and growth factors
Nielsen, Jens Høiriis, Svensson, C., Møldrup, A., Galsgaard, E. D. & Billestrup, Nils, Jan 1999, In: Journal of Molecular Medicine. 77, 1, p. 62-6 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1998
- Published
Molecular mechanism of growth hormone signalling
Billestrup, Nils, Hansen, J. A., Hansen, L. H., Møldrup, A., Galsgaard, E. D. & Nielsen, Jens Høiriis, Apr 1998, In: Endocrine Journal. 45 Suppl, p. S41-5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucagon-like peptide 1 (7-36) amide stimulates exocytosis in human pancreatic beta-cells by both proximal and distal regulatory steps in stimulus-secretion coupling
Gromada, J., Bokvist, K., Ding, W. G., Holst, Jens Juul, Nielsen, Jens Høiriis & Rorsman, P., 1998, In: Diabetes. 47, 1, p. 57-65 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the inhibitory effect of growth hormone on primary preadipocyte differentiation
Hansen, L. H., Madsen, B., Teisner, B., Nielsen, Jens Høiriis & Billestrup, Nils, Aug 1998, In: Molecular endocrinology (Baltimore, Md.). 12, 8, p. 1140-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1997
- Published
Growth hormone and prolactin stimulate the expression of rat preadipocyte factor-1/delta-like protein in pancreatic islets: molecular cloning and expression pattern during development and growth of the endocrine pancreas
Carlsson, C., Tornehave, D., Lindberg, K., Galante, P., Billestrup, Nils, Michelsen, B., Larsson, L. I. & Nielsen, Jens Høiriis, Sep 1997, In: Endocrinology. 138, 9, p. 3940-8 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta-cell ontogeny: growth and death
Corbett, J., Serup, Palle, Bonner-Weir, S. & Nielsen, Jens Høiriis, Oct 1997, In: Diabetologia. 40 Suppl 3, p. B27-32Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The role of GH receptor tyrosine phosphorylation in Stat5 activation
Hansen, J. A., Hansen, Lars Hestbjerg, Wang, X., Kopchick, J. J., Gouilleux, F., Groner, B., Møldrup, A., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, Jun 1997, In: Journal of Molecular Endocrinology. 18, 3, p. 213-21 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1996
- Published
Interleukin-1 beta-induced nitric oxide production from isolated rat islets is modulated by D-glucose and 3-isobutyl-1-methyl xanthine
Andersen, H. U., Mauricio, D., Karlsen, A. E., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Feb 1996, In: European Journal of Endocrinology. 134, 2, p. 251-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of a growth hormone-responsive STAT5-binding element in the rat insulin 1 gene
Galsgaard, E. D., Gouilleux, F., Groner, B., Serup, Palle, Billestrup, Nils & Nielsen, Jens Høiriis, Jun 1996, In: Molecular endocrinology (Baltimore, Md.). 10, 6, p. 652-60 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of tyrosine residues in the intracellular domain of the growth hormone receptor required for transcriptional signaling and Stat5 activation
Hansen, L. H., Wang, X., Kopchick, J. J., Bouchelouche, P., Galsgaard, E. D., Nielsen, Jens Høiriis & Billestrup, Nils, 24 May 1996, In: The Journal of Biological Chemistry. 271, 21, p. 12669-73 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1995
- Published
Identification of phenylalanine 346 in the rat growth hormone receptor as being critical for ligand-mediated internalization and down-regulation
Allevato, G., Billestrup, Nils, Goujon, L., Galsgaard, E. D., Norstedt, G., Postel-Vinay, M. C., Kelly, P. A. & Nielsen, Jens Høiriis, 21 Jul 1995, In: The Journal of Biological Chemistry. 270, 29, p. 17210-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription
Billestrup, Nils, Bouchelouche, P., Allevato, G., Ilondo, M. & Nielsen, Jens Høiriis, 28 Mar 1995, In: Proceedings of the National Academy of Sciences of the United States of America. 92, 7, p. 2725-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular dissection of the growth hormone receptor. Identification of distinct cytoplasmic domains corresponding to different signaling pathways
Billestrup, Nils, Allevato, G., Møldrup, A., Galsgaard, E. D., Amstrup, J., Hansen, J. A., Svensson, C. & Nielsen, Jens Høiriis, 7 Sep 1995, In: Annals of the New York Academy of Sciences. 766, p. 481-3 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Requirement of tyrosine residues 333 and 338 of the growth hormone (GH) receptor for selected GH-stimulated function
Lobie, P. E., Allevato, G., Norstedt, G., Billestrup, Nils & Nielsen, Jens Høiriis, 15 Sep 1995, In: The Journal of Biological Chemistry. 270, 37, p. 21745-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1994
- Published
Identification of intracellular domains in the growth hormone receptor involved in signal transduction
Billestrup, Nils, Allevato, G., Norstedt, G., Møldrup, A. & Nielsen, Jens Høiriis, Jul 1994, In: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 206, 3, p. 205-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cytoplasmic sequences of the growth hormone receptor necessary for signal transduction
Goujon, L., Allevato, G., Simonin, G., Paquereau, L., Le Cam, A., Clark, J., Djiane, J., Postel-Vinay, M. C., Nielsen, Jens Høiriis & Edery, M., 1 Feb 1994, In: Proceedings of the National Academy of Sciences of the United States of America. 91, 3, p. 957-61 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1993
- Published
Growth of the endocrine pancreas: the role of somatolactogenic hormones and receptors
Billestrup, Nils, Møldrup, A., Allevato, G., Petersen, Erik Brinch, Pedersen, Johan, Hansen, J. A. & Nielsen, Jens Høiriis, Feb 1993, In: Biochemical Society Transactions. 21, 1, p. 146-9 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Analysis of proinsulin and its conversion products by reversed-phase high-performance liquid chromatography
Linde, S., Welinder, B. S. & Nielsen, Jens Høiriis, 5 May 1993, In: Journal of Chromatography A. 614, 2, p. 185-204 20 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of sex and pregnancy hormones on growth hormone and prolactin receptor gene expression in insulin-producing cells
Møldrup, A., Petersen, E. D. & Nielsen, Jens Høiriis, Sep 1993, In: Endocrinology. 133, 3, p. 1165-72 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1992
- Published
The role of growth hormone and prolactin in beta cell growth and regeneration
Nielsen, Jens Høiriis, Møldrup, A., Billestrup, Nils, Petersen, E. D., Allevato, G. & Stahl, M., 1992, Pancreatic islet cell regeneration and growth. Vol. 321. p. 9-17; discussion 19-20 (Advances in Experimental Medicine and Biology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Evidence for association of the cloned liver growth hormone receptor with a tyrosine kinase
Wang, X., Uhler, M. D., Billestrup, Nils, Norstedt, G., Talamantes, F., Nielsen, Jens Høiriis & Carter-Su, C., 25 Aug 1992, In: The Journal of Biological Chemistry. 267, 24, p. 17390-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1991
- Published
The stimulatory effect of growth hormone, prolactin, and placental lactogen on beta-cell proliferation is not mediated by insulin-like growth factor-I
Billestrup, Nils & Nielsen, Jens Høiriis, Aug 1991, In: Endocrinology. 129, 2, p. 883-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Islet amyloid polypeptide and insulin expression are controlled differently in primary and transformed islet cells
Madsen, O. D., Michelsen, B. T., Westermark, P., Betsholtz, C., Nishi, M., Steiner, D. F. & Nielsen, Jens Høiriis, Jan 1991, In: Molecular endocrinology (Baltimore, Md.). 5, 1, p. 143-8 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth hormone action in rat insulinoma cells expressing truncated growth hormone receptors
Møldrup, A., Allevato, G., Dyrberg, T., Billestrup, Nils & Nielsen, Jens Høiriis, 15 Sep 1991, In: The Journal of Biological Chemistry. 266, 26, p. 17441-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transport of ascorbic acid and dehydroascorbic acid by pancreatic islet cells from neonatal rats
Zhou, A., Farver, O., Thorn, N. A. & Nielsen, Jens Høiriis, 1991, In: Biochemical Journal. 274 ( Pt 3), p. 739-44 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1990
- Published
Introduction of exogenous growth hormone receptors augments growth hormone-responsive insulin biosynthesis in rat insulinoma cells
Billestrup, Nils, Møldrup, A., Serup, Palle, Mathews, L. S., Norstedt, G. & Nielsen, Jens Høiriis, Sep 1990, In: Proceedings of the National Academy of Sciences of the United States of America. 87, 18, p. 7210-4 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of 5'-flanking sequence deletions on expression of the human insulin gene in transgenic mice
Fromont-Racine, M., Bucchini, D., gjc556, gjc556, Desbois, P., Linde, S., Saulnier, C., Ripoche, M. A., Jami, J., Pictet, R. & Nielsen, Jens Høiriis, May 1990, In: Molecular endocrinology (Baltimore, Md.). 4, 5, p. 669-77 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
High-performance liquid chromatography of rat and mouse islet polypeptides: potential risk of oxidation of methionine residues during sample preparation
Linde, S., Hansen, Birger, Welinder, B. S. & Nielsen, Jens Høiriis, 24 Aug 1990, In: Journal of Chromatography A. 530, 1, p. 29-37 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of the growth hormone receptor gene in insulin producing cells
Møldrup, A., Billestrup, Nils & Nielsen, Jens Høiriis, 1990, In: Biomedica Biochimica Acta. 49, 12, p. 1151-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Rat insulinoma cells express both a 115-kDa growth hormone receptor and a 95-kDa prolactin receptor structurally related to the hepatic receptors
Møldrup, A., Billestrup, Nils & Nielsen, Jens Høiriis, 25 May 1990, In: The Journal of Biological Chemistry. 265, 15, p. 8686-90 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of growth hormone and serum on the expression of the proto-oncogenes c-jun and c-fos in insulin producing cells
Petersen, E. D., Billestrup, Nils & Nielsen, Jens Høiriis, 1990, In: Biomedica Biochimica Acta. 49, 12, p. 1171-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1989
- Published
Direct long-term effects of L-asparaginase on rat and human pancreatic islets
Clausen, N. & Nielsen, Jens Høiriis, Aug 1989, In: Pediatric Research. 26, 2, p. 158-61 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Supravital dithizone staining in the isolation of human and rat pancreatic islets
Hansen, W. A., Christie, M. R., Kahn, R., Norgaard, A., Abel, I., Petersen, A. M., Jorgensen, D. W., Baekkeskov, S., Nielsen, Jens Høiriis & Lernmark, A., Feb 1989, In: Diabetes Research: Clinical & Experimental. 10, 2, p. 53-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pancreatic hormones are expressed on the surfaces of human and rat islet cells through exocytotic sites
Larsson, L. I., Hutton, J. C., Madsen, O. D. & Nielsen, Jens Høiriis, Feb 1989, In: European Journal of Cell Biology. 48, 1, p. 45-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth hormone is a growth factor for the differentiated pancreatic beta-cell
Linde, S., Welinder, B. S., Billestrup, Nils, Madsen, O. D. & Nielsen, Jens Høiriis, Jan 1989, In: Molecular endocrinology (Baltimore, Md.). 3, 1, p. 165-73 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Reversed-phase high-performance liquid chromatographic analyses of insulin biosynthesis in isolated rat and mouse islets
Linde, S., Hansen, B. A., Welinder, B. S. & Nielsen, Jens Høiriis, 13 Jan 1989, In: Journal of Chromatography A. 462, p. 243-54 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multiple growth hormone-binding proteins are expressed on insulin-producing cells
Møldrup, A., Billestrup, Nils, Thorn, N. A., Lernmark, A. & Nielsen, Jens Høiriis, Aug 1989, In: Molecular endocrinology (Baltimore, Md.). 3, 8, p. 1173-82 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of pancreatic beta-cell growth and regeneration: studies on rat insulinoma cells
Nielsen, Jens Høiriis, 1989, In: Experimental and Clinical Endocrinology and Diabetes. Supplement. 93, 2-3, p. 277-85 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1988
- Published
Effect of interleukin-1 on the biosynthesis of proinsulin and insulin in isolated rat pancreatic islets
Hansen, B. S., Linde, S., Spinas, G. A., Welinder, B. S., Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, 1988, In: Biomedica Biochimica Acta. 47, 4-5, p. 305-9 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Gene probes to detect cross-culture contamination in hormone producing cell lines
Matsuba, I., Lernmark, A., Madsen, O. D., Michelsen, B., Nielsen, Jens Høiriis, Scholler, J., Vissing, H., Welinder, B., Tommerup, Niels & Mikkelsen, M., Nov 1988, In: In Vitro Cellular & Developmental Biology. 24, 11, p. 1071-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Truncated glucagon-like peptide-1 (proglucagon 78-107 amide), an intestinal insulin-releasing peptide, has specific receptors on rat insulinoma cells (RIN 5AH)
Ørskov, Cathrine & Nielsen, Jens Høiriis, 29 Feb 1988, In: FEBS Letters. 229, 1, p. 175-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The bimodal effect of interleukin 1 on rat pancreatic beta-cells--stimulation followed by inhibition--depends upon dose, duration of exposure, and ambient glucose concentration
Spinas, G. A., Palmer, J. P., Mandrup-Poulsen, Thomas, Andersen, Heine, Nerup, J. & Nielsen, Jens Høiriis, Oct 1988, In: Acta Endocrinologica. 119, 2, p. 307-11 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1987
- Published
Tissue-type plasminogen activator in somatostatin cells of rat pancreas and hypothalamus
Kristensen, P., Larsson, L. I., Danø, K. & Nielsen, Jens Høiriis, Dec 1987, In: Endocrinology. 121, 6, p. 2238-44 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Islet cytotoxicity of interleukin 1. Influence of culture conditions and islet donor characteristics
Mandrup-Poulsen, Thomas, Spinas, G. A., Prowse, S. J., Hansen, B. S., Jørgensen, D. W., Bendtzen, K., Nerup, J. & Nielsen, Jens Høiriis, May 1987, In: Diabetes. 36, 5, p. 641-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ultrastructural studies of time-course and cellular specificity of interleukin-1 mediated islet cytotoxicity
Mandrup-Poulsen, Thomas, Egeberg, J., Nerup, J., Bendtzen, K., Dinarello, C. A. & Nielsen, Jens Høiriis, Apr 1987, In: Acta pathologica, microbiologica, et immunologica Scandinavica. Section C, Immunology. 95, 2, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Interleukin 1 dose-dependently affects the biosynthesis of (pro)insulin in isolated rat islets of Langerhans
Spinas, G. A., Hansen, B. S., Linde, S., Kastern, W., Mølvig, J., Mandrup-Poulsen, Thomas, Dinarello, C. A., Nerup, J. & Nielsen, Jens Høiriis, Jul 1987, In: Diabetologia. 30, 7, p. 474-80 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1986
- Published
Cytotoxicity of human pI 7 interleukin-1 for pancreatic islets of Langerhans
Bendtzen, K., Mandrup-Poulsen, Thomas, Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, 20 Jun 1986, In: Science (New York, N.Y.). 232, 4757, p. 1545-7 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Localization and biosynthesis of polyamines in insulin-producing cells
Hougaard, D. M., Larsson, L. I. & Nielsen, Jens Høiriis, 15 Aug 1986, In: Biochemical Journal. 238, 1, p. 43-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Dinarello, C. A., Svenson, M. & Nielsen, Jens Høiriis, Jan 1986, In: Diabetologia. 29, 1, p. 63-7 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Direct effects of cyclosporin A on human pancreatic beta-cells
Mandrup-Poulsen, Thomas, Nerup, J. & Nielsen, Jens Høiriis, Sep 1986, In: Diabetes. 35, 9, p. 1049-52 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanisms of pancreatic islet cell destruction. Dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Nerup, J., Egeberg, J. & Nielsen, Jens Høiriis, May 1986, In: Allergy. 41, 4, p. 250-9 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1985
- Published
Cytokines cause functional and structural damage to isolated islets of Langerhans
Mandrup-Poulsen, Thomas, Bendtzen, K., Bendixen, G., Nerup, J. & Nielsen, Jens Høiriis, Aug 1985, In: Allergy. 40, 6, p. 424-9 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dissociation between insulin secretion and DNA synthesis in cultured pancreatic islets
Nielsen, Jens Høiriis, 1985, In: Biomedica Biochimica Acta. 44, 1, p. 161-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Growth and function of the pancreatic beta cell in vitro: effects of glucose, hormones and serum factors on mouse, rat and human pancreatic islets in organ culture
Nielsen, Jens Høiriis, 1985, In: Acta endocrinologica. Supplementum. 266, p. 1-39 39 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1984
- Published
Direct effect of gonadal and contraceptive steroids on insulin release from mouse pancreatic islets in organ culture
Nielsen, Jens Høiriis, Feb 1984, In: Acta Endocrinologica. 105, 2, p. 245-50 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1983
- Published
Biosynthesis and release of thyrotropin-releasing hormone immunoreactivity in rat pancreatic islets in organ culture. Effects of age, glucose, and streptozotocin
Dolva, L. O., Welinder, B. S., Hanssen, K. F. & Nielsen, Jens Høiriis, Dec 1983, In: The Journal of Clinical Investigation. 72, 6, p. 1867-73 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Variations in insulin responsiveness in rat fat cells are due to metabolic differences rather than insulin binding
Hansen, F. M., Nilsson, P., Sonne, O., Hustvedt, B. E., Nilsson-Ehle, P., Løvø, A. & Nielsen, Jens Høiriis, Feb 1983, In: Diabetologia. 24, 2, p. 131-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1982
- Published
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
Baekkeskov, S., Marner, B., Bilde, T., Ludvigsson, J., Lernmark, A. & Nielsen, Jens Høiriis, 8 Jul 1982, In: Nature. 298, 5870, p. 167-9 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New approaches to therapy and diagnosis of diabetes
Hansen, B. A., Lernmark, A., Owerbach, D., Welinder, B. & Nielsen, Jens Høiriis, Feb 1982, In: Diabetologia. 22, 2, p. 61-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effects of growth hormone, prolactin, and placental lactogen on insulin content and release, and deoxyribonucleic acid synthesis in cultured pancreatic islets
Nielsen, Jens Høiriis, Feb 1982, In: Endocrinology. 110, 2, p. 600-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1981
- Published
Direct long-term effect of hydrocortisone on insulin and glucagon release from mouse pancreatic islets in tissue culture
Brunstedt, J. & Nielsen, Jens Høiriis, Apr 1981, In: Acta Endocrinologica. 96, 4, p. 498-504 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Stimulatory effect of serum from diabetic patients on insulin release from mouse pancreatic islets maintained in tissue culture
Eff, C., Deckert, T., Andersson, A. & Nielsen, Jens Høiriis, 1981, In: Diabetologia. 20, 1, p. 60-5 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Beta-cell function in isolated human pancreatic islets in long-term tissue culture
Nielsen, Jens Høiriis, 1981, In: Acta Biologica et Medica Germanica. 40, 1, p. 55-60 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1980
- Published
The influence of sexual hormones on lipogenesis and lipolysis in rat fat cells
Hansen, F. M., Fahmy, N. & Nielsen, Jens Høiriis, Dec 1980, In: Acta Endocrinologica. 95, 4, p. 566-70 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1979
- Published
Preservation of beta cell function in adult human pancreatic islets for several months in vitro
Brunstedt, J., Andersson, A., Frimodt-Møller, C. & Nielsen, Jens Høiriis, Feb 1979, In: Diabetologia. 16, 2, p. 97-100 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1978
- Published
Long-term effect of pH on B-cell function in isolated islets of Langerhans in tissue culture
Brunstedt, J. & Nielsen, Jens Høiriis, Sep 1978, In: Diabetologia. 15, 3, p. 181-5 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1974
- Published
The influence of body weight and cell size on lipogenesis and lipolysis of isolated rat fat cells
Hansen, F. M., Gliemann, J. & Nielsen, Jens Høiriis, 5 Dec 1974, In: European Journal of Clinical Investigation. 4, 6, p. 411-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 1969
- Published
Binding of zinc to insulin and some insulin derivatives studied by paper electrophoresis
Brunfeldt, K., Hansen, B. A. & Nielsen, Jens Høiriis, Jul 1969, In: Acta Endocrinologica. 61, 3, p. 561-76 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 5594
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Programming of glucose-insulin homoeostasis: long-term consequences of pre-natal versus early post-natal nutrition insults. Evidence from a sheep model
Research output: Contribution to journal › Journal article › Research › peer-review
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Expression and Localization of microRNAs in Perinatal Rat Pancreas: Role of miR-21 in Regulation of Cholesterol Metabolism
Research output: Contribution to journal › Journal article › Research › peer-review
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Beta cell adaptation in pregnancy: a tribute to Claes Hellerström
Research output: Contribution to journal › Review › Research › peer-review
Published