Expression of SMAD signal transduction molecules in the pancreas
Research output: Contribution to journal › Journal article › Research › peer-review
Members of the TGF-beta superfamily of cytokines have been implicated in pancreatic cancer, pancreatitis and in regulation and differentiation of pancreatic endocrine and exocrine cells. Different TGF-beta members signal through phosphorylation of different signal transduction proteins, which eventually form oligomers with SMAD 4 and translocate to the nucleus. Reverse transcriptase-polymerase chain reaction showed that SMADs 1, 2 and 4 are expressed in pancreatic islets. Immunostaining revealed that SMAD 1 and 4 predominantly were expressed by islet insulin and glucagon cells. Since SMAD 1 is known to transduce signals from receptors binding bone morphogenetic protein (BMP) these results indicate a previously unknown role of BMP-like ligands in islet function.
| Original language | English |
|---|---|
| Journal | Histochemistry and Cell Biology |
| Volume | 116 |
| Issue number | 3 |
| Pages (from-to) | 263-7 |
| Number of pages | 5 |
| ISSN | 0948-6143 |
| DOIs | |
| Publication status | Published - 2001 |
- Animals, Animals, Newborn, DNA-Binding Proteins, Fluorescein-5-isothiocyanate, Fluorescent Antibody Technique, Gene Expression, Immunohistochemistry, Pancreas, RNA, Messenger, Rats, Rats, Wistar, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Smad Proteins, Smad1 Protein, Smad2 Protein, Smad4 Protein, Trans-Activators
Research areas
ID: 47972420