Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study

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Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study. / Juhl, Pernille; Bay-Jensen, Anne-Christine; Hesselstrand, Roger; Siebuhr, Anne S.; Wuttge, Dirk M.

I: Scientific Reports, Bind 10, Nr. 1, 7145, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Juhl, P, Bay-Jensen, A-C, Hesselstrand, R, Siebuhr, AS & Wuttge, DM 2020, 'Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study', Scientific Reports, bind 10, nr. 1, 7145. https://doi.org/10.1038/s41598-020-64233-8

APA

Juhl, P., Bay-Jensen, A-C., Hesselstrand, R., Siebuhr, A. S., & Wuttge, D. M. (2020). Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study. Scientific Reports, 10(1), [7145]. https://doi.org/10.1038/s41598-020-64233-8

Vancouver

Juhl P, Bay-Jensen A-C, Hesselstrand R, Siebuhr AS, Wuttge DM. Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study. Scientific Reports. 2020;10(1). 7145. https://doi.org/10.1038/s41598-020-64233-8

Author

Juhl, Pernille ; Bay-Jensen, Anne-Christine ; Hesselstrand, Roger ; Siebuhr, Anne S. ; Wuttge, Dirk M. / Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study. I: Scientific Reports. 2020 ; Bind 10, Nr. 1.

Bibtex

@article{c9300c9b48184dba9040fff46d552c4a,
title = "Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study",
abstract = "Tissue turnover, especially in the skin, is altered in systemic sclerosis (SSc), leading to tissue accumulation. The objective was to examine type III, IV, and VI collagens turnovers in SSc and investigate longitudinal alterations in relation to modified Rodnan Skin Score (mRSS). We included patients fulfilling the 2013 ACR/EULAR criteria for SSc (limited cutaneous [lcSSc, n=20], diffuse cutaneous SSc [dcSSc, n=23]) and healthy controls (HC, n=10). Biomarkers of type III, IV, and VI collagens formation (PRO-C3, PRO-C4, PRO-C6) and degradation (C3M, C4M, C6M) were measured in serum. The fibrotic index of the individual collagens (FICol) were calculated. The fibrotic index of type III and VI collagens (FICol3 and FICol6) were increased in dcSSc compared to lcSSc (FICol3: 1.4 vs. 0.8, P=0.0001; FICol6: 1.2 vs. 0.9, P=0.03). The fibrotic index of type IV collagen (FICol4) was not different between the groups but was 1.5 times higher than HC (HC: 6.9, lcSSc 10.4, dcSSc: 10.5). Both FICol3 and FICol6 correlated with mRSS with rho's of 0.59 (P",
keywords = "CLASSIFICATION, SKIN",
author = "Pernille Juhl and Anne-Christine Bay-Jensen and Roger Hesselstrand and Siebuhr, {Anne S.} and Wuttge, {Dirk M.}",
year = "2020",
doi = "10.1038/s41598-020-64233-8",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Type III, IV, and VI Collagens Turnover in Systemic Sclerosis - a Longitudinal Study

AU - Juhl, Pernille

AU - Bay-Jensen, Anne-Christine

AU - Hesselstrand, Roger

AU - Siebuhr, Anne S.

AU - Wuttge, Dirk M.

PY - 2020

Y1 - 2020

N2 - Tissue turnover, especially in the skin, is altered in systemic sclerosis (SSc), leading to tissue accumulation. The objective was to examine type III, IV, and VI collagens turnovers in SSc and investigate longitudinal alterations in relation to modified Rodnan Skin Score (mRSS). We included patients fulfilling the 2013 ACR/EULAR criteria for SSc (limited cutaneous [lcSSc, n=20], diffuse cutaneous SSc [dcSSc, n=23]) and healthy controls (HC, n=10). Biomarkers of type III, IV, and VI collagens formation (PRO-C3, PRO-C4, PRO-C6) and degradation (C3M, C4M, C6M) were measured in serum. The fibrotic index of the individual collagens (FICol) were calculated. The fibrotic index of type III and VI collagens (FICol3 and FICol6) were increased in dcSSc compared to lcSSc (FICol3: 1.4 vs. 0.8, P=0.0001; FICol6: 1.2 vs. 0.9, P=0.03). The fibrotic index of type IV collagen (FICol4) was not different between the groups but was 1.5 times higher than HC (HC: 6.9, lcSSc 10.4, dcSSc: 10.5). Both FICol3 and FICol6 correlated with mRSS with rho's of 0.59 (P

AB - Tissue turnover, especially in the skin, is altered in systemic sclerosis (SSc), leading to tissue accumulation. The objective was to examine type III, IV, and VI collagens turnovers in SSc and investigate longitudinal alterations in relation to modified Rodnan Skin Score (mRSS). We included patients fulfilling the 2013 ACR/EULAR criteria for SSc (limited cutaneous [lcSSc, n=20], diffuse cutaneous SSc [dcSSc, n=23]) and healthy controls (HC, n=10). Biomarkers of type III, IV, and VI collagens formation (PRO-C3, PRO-C4, PRO-C6) and degradation (C3M, C4M, C6M) were measured in serum. The fibrotic index of the individual collagens (FICol) were calculated. The fibrotic index of type III and VI collagens (FICol3 and FICol6) were increased in dcSSc compared to lcSSc (FICol3: 1.4 vs. 0.8, P=0.0001; FICol6: 1.2 vs. 0.9, P=0.03). The fibrotic index of type IV collagen (FICol4) was not different between the groups but was 1.5 times higher than HC (HC: 6.9, lcSSc 10.4, dcSSc: 10.5). Both FICol3 and FICol6 correlated with mRSS with rho's of 0.59 (P

KW - CLASSIFICATION

KW - SKIN

U2 - 10.1038/s41598-020-64233-8

DO - 10.1038/s41598-020-64233-8

M3 - Journal article

C2 - 32346065

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 7145

ER -

ID: 247935822