The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract
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The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract. / Rhee, Nicolai Alexander; Vilmann, Peter; Hassan, Hazem; Hendel, Jakob Westergren; Holst, Jens Juul; Vilsbøll, Tina; Knop, Filip Krag.
I: Scandinavian Journal of Gastroenterology, Bind 49, Nr. 9, 09.2014, s. 1143-1149.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The use of double-balloon enteroscopy in retrieving mucosal biopsies from the entire human gastrointestinal tract
AU - Rhee, Nicolai Alexander
AU - Vilmann, Peter
AU - Hassan, Hazem
AU - Hendel, Jakob Westergren
AU - Holst, Jens Juul
AU - Vilsbøll, Tina
AU - Knop, Filip Krag
PY - 2014/9
Y1 - 2014/9
N2 - OBJECTIVE: The aim of this explorative study was to evaluate double-balloon enteroscopy (DBE) as a new tool for collecting mucosal biopsies from well-defined parts of the entire small and large bowel in patients with type 2 diabetes and in matched healthy subjects.MATERIAL AND METHODS: Twelve subjects with type 2 diabetes and 12 body mass index and age-matched healthy subjects underwent anterograde and retrograde DBE under nurse-administered propofol sedation on two separate days. We attempted to collect two mucosal biopsies from every 30 cm from pylorus to rectum.RESULTS: A mean of 21 biopsy sites were sampled in the diabetic group versus 25 in the healthy group. In 4 out of 24 patients (2 [17%] from each group) sampling from the entire gastrointestinal system was possible. Mean depth of maximal insertion (anterograde) was 478 ± 32 cm in patients with type 2 diabetes versus 465 ± 44 cm in healthy subjects (p = 0.81) and with retrograde access 230 ± 36 cm (type 2 diabetes) versus 207 ± 26 cm (healthy subjects).CONCLUSIONS: DBE is a minimally invasive way of collecting fresh biopsies from the entire gastrointestinal tract and, thus provides research and clinical communities with a new possibility to access hitherto unexplored human anatomy and physiology.
AB - OBJECTIVE: The aim of this explorative study was to evaluate double-balloon enteroscopy (DBE) as a new tool for collecting mucosal biopsies from well-defined parts of the entire small and large bowel in patients with type 2 diabetes and in matched healthy subjects.MATERIAL AND METHODS: Twelve subjects with type 2 diabetes and 12 body mass index and age-matched healthy subjects underwent anterograde and retrograde DBE under nurse-administered propofol sedation on two separate days. We attempted to collect two mucosal biopsies from every 30 cm from pylorus to rectum.RESULTS: A mean of 21 biopsy sites were sampled in the diabetic group versus 25 in the healthy group. In 4 out of 24 patients (2 [17%] from each group) sampling from the entire gastrointestinal system was possible. Mean depth of maximal insertion (anterograde) was 478 ± 32 cm in patients with type 2 diabetes versus 465 ± 44 cm in healthy subjects (p = 0.81) and with retrograde access 230 ± 36 cm (type 2 diabetes) versus 207 ± 26 cm (healthy subjects).CONCLUSIONS: DBE is a minimally invasive way of collecting fresh biopsies from the entire gastrointestinal tract and, thus provides research and clinical communities with a new possibility to access hitherto unexplored human anatomy and physiology.
U2 - 10.3109/00365521.2014.934912
DO - 10.3109/00365521.2014.934912
M3 - Journal article
C2 - 24998781
VL - 49
SP - 1143
EP - 1149
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 9
ER -
ID: 132002571