The Use and Effectiveness of Selected Alternative Markers for Insulin Sensitivity and Secretion Compared with Gold Standard Markers in Dietary Intervention Studies in Individuals without Diabetes: Results of a Systematic Review
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Background: The gold‐standard techniques for measuring insulin sensitivity and secretion are well established. However, they may be perceived as invasive and expensive for use in dietary intervention studies. Thus, surrogate markers have been proposed as alternative markers for insulin sensitivity and secretion. This systematic review aimed to identify markers of insulin sensitivity and secretion in response to dietary intervention and assess their suitability as surrogates for the gold‐standard method-ology. Methods: Three databases, PubMed, Scopus, and Cochrane were searched, intervention studies and randomised controlled trials reporting data on dietary intake, a gold standard of analysis of insulin sensitivity (either euglycaemic‐hyperinsulinaemic clamp or intravenous glucose tolerance test and secretion (acute insulin response to glucose), as well as surrogate markers for insulin sensitivity (either fasting insulin, area under the curve oral glucose tolerance tests and HOMA‐IR) and insulin secretion (disposi-tion index), were selected. Results: We identified thirty‐five studies that were eligible for inclusion. We found insufficient evidence to predict insulin sensitivity and secretion with surrogate markers when compared to gold standards in nutritional intervention studies. Conclusions: Future research is needed to investigate if surrogate measures of insulin sensitivity and secretion can be repeatable and reproduci-ble in the same way as gold standards.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 2036 |
| Tidsskrift | Nutrients |
| Vol/bind | 14 |
| Udgave nummer | 10 |
| Sider (fra-til) | 1-27 |
| ISSN | 2072-6643 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
The National Starch LLC and by infrastructure funding support from the Medical Research Council and the NIHR Biomedical Facility.
Funding Information:
Finland, the Nordic Centre of Excellence on Systems Biology in Controlled Dietary In‐ terventions and Cohort Studies, the European Nutrigenomics Organi‐ sation, the Yrj¨o Jahnsson Foundation, the Juho Vainio Foun‐ dation, the ABS Gradu‐ ate School, and the Medical Research Fund of Tam pere Uni‐ versity Hospital.
Funding Information:
The National Institutes of Cancer, University of Southern California Centre for Transdisci‐ plinary Research on Energetics and Cancer, the National Institute of Child Health and Human Development, the National Cancer Institute (Cancer Con‐ trol and Epidemiology Research Training Grant), the Dr Robert C. and Veronica Atkins Foundation The National Institutes of Cancer, University of Southern California Centre for Transdisci‐ plinary Research on Energetics and Cancer,
Funding Information:
NHMRC Neil Hamilton Fairley Fellowship and an wash‐out 84 + 42 Early Career Researcher Grant from the University of Melbourne.
Funding Information:
Veterans Affairs and Vet‐ erans Affairs Medical Centre GRECC, National Institute on Aging Grants, Claude D. Pepper Older Americans Independence Centre Grant P30‐AG‐ 028747, the National Insti‐ tute of Diabetes and Di‐ gestive and Kidney Dis‐ eases Mid‐Atlantic Nutri‐ tion Obesity Research Centre, and the General Clinical Research Centre of the University of Mary‐ land, Baltimore, Mary‐ land. Steno Diabetes Centre, Gentofte, Denmark and by Aase and Ejnar Dan‐ ielsens Foundation, Lyngby, Denmark
Funding Information:
European Commission in the 6th Framework Programme, Project HEALTHGRAIN, by Raisio Plc Research Foundation (JL), the Nordic Centre of Ex‐ cellence projects “HELGA whole grains and health”, “SYSDIET Systems biology in controlled dietary in‐ terventions and cohort studies” (MK, US, MU). Barilla G&R F.lli. SpA, Parma, Italy and Raiso Nutrition Ltd., Finland.
Funding Information:
42 (7 Supported by grants from days of the Swiss National Science study + Foundation and by grants 35 wash‐ from the Novartis Foun‐ out days) dation and Takeda.
Funding Information:
The German Ministry of Education and Research, the German Research Foundation, and the BMBF Kompetenznetz Adipositas, Core Domain “Body composition”
Funding Information:
Princess Alexandra Re‐ search Foundation, the Li‐ ons Medical Research Foundation, and the Na‐ tional Health and Medical Research Council of Aus‐ tralia
Funding Information:
the National Institute of Child Health and Human Development, the National Cancer Institute (Cancer Con‐ trol and Epidemiology Research Training Grant), the Dr Robert C. and Veronica Atkins Foundation
Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
ID: 311340219