The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
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Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be protective against diabetes, although the mechanisms remain largely unknown. The aim of this study was to determine how SIRT1 regulates insulin secretion in the pancreatic beta cell.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Diabetologia |
| Vol/bind | 56 |
| Udgave nummer | 9 |
| Sider (fra-til) | 2010-20 |
| Antal sider | 11 |
| ISSN | 0012-186X |
| DOI | |
| Status | Udgivet - sep. 2013 |
ID: 111087585