The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
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The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing. / Luu, L; Dai, F F; Prentice, K J; Huang, X; Hardy, A B; Hansen, Jakob Bondo; Liu, Y; Joseph, J W; Wheeler, M B.
I: Diabetologia, Bind 56, Nr. 9, 09.2013, s. 2010-20.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The loss of Sirt1 in mouse pancreatic beta cells impairs insulin secretion by disrupting glucose sensing
AU - Luu, L
AU - Dai, F F
AU - Prentice, K J
AU - Huang, X
AU - Hardy, A B
AU - Hansen, Jakob Bondo
AU - Liu, Y
AU - Joseph, J W
AU - Wheeler, M B
PY - 2013/9
Y1 - 2013/9
N2 - Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be protective against diabetes, although the mechanisms remain largely unknown. The aim of this study was to determine how SIRT1 regulates insulin secretion in the pancreatic beta cell.
AB - Sirtuin 1 (SIRT1) has emerged as a key metabolic regulator of glucose homeostasis and insulin secretion. Enhanced SIRT1 activity has been shown to be protective against diabetes, although the mechanisms remain largely unknown. The aim of this study was to determine how SIRT1 regulates insulin secretion in the pancreatic beta cell.
U2 - 10.1007/s00125-013-2946-5
DO - 10.1007/s00125-013-2946-5
M3 - Journal article
C2 - 23783352
VL - 56
SP - 2010
EP - 2020
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 9
ER -
ID: 111087585