The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs

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Standard

The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs. / Poulsen, Steen Seier.

I: Scandinavian Journal of Gastroenterology, Bind 18, Nr. 3, 05.1983, s. 407-10.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, SS 1983, 'The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs', Scandinavian Journal of Gastroenterology, bind 18, nr. 3, s. 407-10.

APA

Poulsen, S. S. (1983). The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs. Scandinavian Journal of Gastroenterology, 18(3), 407-10.

Vancouver

Poulsen SS. The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs. Scandinavian Journal of Gastroenterology. 1983 maj;18(3):407-10.

Author

Poulsen, Steen Seier. / The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs. I: Scandinavian Journal of Gastroenterology. 1983 ; Bind 18, Nr. 3. s. 407-10.

Bibtex

@article{6cfbb57710be4af3abf8380e41015136,
title = "The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs",
abstract = "By oral administration of degraded carrageenan a colitis-like disease can be induced in guinea pigs which almost exclusively affects the caecum. To study the effect of degraded carrageenan on the distal colon and rectum, an ileotransversostomy was performed. In the non-operated group of animals ulcerative lesions and changes in the mucosal surface structure were observed only in the caecum and proximal colon after administration of degraded carrageenan. Animals with ileotransversostomy had similar lesions, but the distal colon and rectum were also severely affected, with formation of crypt abscesses in the rectum. This study indicates that the long transit time in the caecum, which enables bacterial decomposition and/or absorption of degraded carrageenan, is the reason that only the proximal colon is affected in non-operated animals. After ileotransversostomy degraded carrageenan reaches the distal colon in an active form that produces ulcerative changes.",
keywords = "Animals, Carrageenan, Cecal Diseases, Cecum, Colitis, Colon, Female, Guinea Pigs, Ileum, Inflammation, Intestinal Mucosa, Rectum",
author = "Poulsen, {Steen Seier}",
year = "1983",
month = may,
language = "English",
volume = "18",
pages = "407--10",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "3",

}

RIS

TY - JOUR

T1 - The effect of ileotransversostomy on carrageenan-induced colitis in guinea pigs

AU - Poulsen, Steen Seier

PY - 1983/5

Y1 - 1983/5

N2 - By oral administration of degraded carrageenan a colitis-like disease can be induced in guinea pigs which almost exclusively affects the caecum. To study the effect of degraded carrageenan on the distal colon and rectum, an ileotransversostomy was performed. In the non-operated group of animals ulcerative lesions and changes in the mucosal surface structure were observed only in the caecum and proximal colon after administration of degraded carrageenan. Animals with ileotransversostomy had similar lesions, but the distal colon and rectum were also severely affected, with formation of crypt abscesses in the rectum. This study indicates that the long transit time in the caecum, which enables bacterial decomposition and/or absorption of degraded carrageenan, is the reason that only the proximal colon is affected in non-operated animals. After ileotransversostomy degraded carrageenan reaches the distal colon in an active form that produces ulcerative changes.

AB - By oral administration of degraded carrageenan a colitis-like disease can be induced in guinea pigs which almost exclusively affects the caecum. To study the effect of degraded carrageenan on the distal colon and rectum, an ileotransversostomy was performed. In the non-operated group of animals ulcerative lesions and changes in the mucosal surface structure were observed only in the caecum and proximal colon after administration of degraded carrageenan. Animals with ileotransversostomy had similar lesions, but the distal colon and rectum were also severely affected, with formation of crypt abscesses in the rectum. This study indicates that the long transit time in the caecum, which enables bacterial decomposition and/or absorption of degraded carrageenan, is the reason that only the proximal colon is affected in non-operated animals. After ileotransversostomy degraded carrageenan reaches the distal colon in an active form that produces ulcerative changes.

KW - Animals

KW - Carrageenan

KW - Cecal Diseases

KW - Cecum

KW - Colitis

KW - Colon

KW - Female

KW - Guinea Pigs

KW - Ileum

KW - Inflammation

KW - Intestinal Mucosa

KW - Rectum

M3 - Journal article

C2 - 6673066

VL - 18

SP - 407

EP - 410

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 3

ER -

ID: 47489602