Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

  • Joshua C Randall
  • Thomas W Winkler
  • Zoltán Kutalik
  • Sonja I Berndt
  • Anne U Jackson
  • Keri L Monda
  • Oskari Kilpeläinen, Tuomas
  • Tõnu Esko
  • Reedik Mägi
  • Shengxu Li
  • Tsegaselassie Workalemahu
  • Mary F Feitosa
  • Damien C Croteau-Chonka
  • Felix R Day
  • Tove Fall
  • Teresa Ferreira
  • Stefan Gustafsson
  • Adam E Locke
  • Iain Mathieson
  • Andre Scherag
  • Sailaja Vedantam
  • Andrew R Wood
  • Liming Liang
  • Valgerdur Steinthorsdottir
  • Gudmar Thorleifsson
  • Emmanouil T Dermitzakis
  • Antigone S Dimas
  • Fredrik Karpe
  • Josine L Min
  • George Nicholson
  • Deborah J Clegg
  • Thomas Person
  • Jon P Krohn
  • Sabrina Bauer
  • Christa Buechler
  • Kristina Eisinger
  • Amélie Bonnefond
  • Philippe Froguel
  • Jouke-Jan Hottenga
  • Inga Prokopenko
  • Lindsay L Waite
  • Tamara B Harris
  • Albert Vernon Smith
  • Alan R Shuldiner
  • Wendy L McArdle
  • Mark J Caulfield
  • Peter Kovacs
  • Schwarz, Peter
  • Lars Lind
  • Inger Njølstad
  • DIAGRAM Consortium
Given the anthropometric differences between men and women and previous evidence of sex-difference in genetic effects, we conducted a genome-wide search for sexually dimorphic associations with height, weight, body mass index, waist circumference, hip circumference, and waist-to-hip-ratio (133,723 individuals) and took forward 348 SNPs into follow-up (additional 137,052 individuals) in a total of 94 studies. Seven loci displayed significant sex-difference (FDR
OriginalsprogEngelsk
Artikelnummere1003500
TidsskriftP L o S Genetics
Vol/bind9
Udgave nummer6
Sider (fra-til)1-19
Antal sider20
ISSN1553-7390
DOI
StatusUdgivet - jun. 2013

ID: 46279463