Secretion of goblet cell serine proteinase, ingobsin, is stimulated by vasoactive intestinal polypeptide and acetylcholine
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Secretion of goblet cell serine proteinase, ingobsin, is stimulated by vasoactive intestinal polypeptide and acetylcholine. / Poulsen, Steen Seier; Nexø, Ebba.
I: Digestion, Bind 37, Nr. 4, 1987, s. 223-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Secretion of goblet cell serine proteinase, ingobsin, is stimulated by vasoactive intestinal polypeptide and acetylcholine
AU - Poulsen, Steen Seier
AU - Nexø, Ebba
PY - 1987
Y1 - 1987
N2 - Ingobsin is localized to the intestinal goblet cells in the rat and in man. In the present study, we investigated the effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on the secretion of ingobsin from the proximal duodenum. Intravenous infusion of VIP or acetylcholine increased the concentration of ingobsin in duodenal secretion, while the concentration in the duodenum was unchanged. Simultaneous infusion of VIP and acetylcholine increased the concentration of ingobsin in duodenal secretion and decreased the concentration of ingobsin in the duodenum. This study demonstrates that secretion of ingobsin from the proximal duodenum is exocrine and can be stimulated by VIP and acetylcholine.
AB - Ingobsin is localized to the intestinal goblet cells in the rat and in man. In the present study, we investigated the effect of vasoactive intestinal polypeptide (VIP) and acetylcholine on the secretion of ingobsin from the proximal duodenum. Intravenous infusion of VIP or acetylcholine increased the concentration of ingobsin in duodenal secretion, while the concentration in the duodenum was unchanged. Simultaneous infusion of VIP and acetylcholine increased the concentration of ingobsin in duodenal secretion and decreased the concentration of ingobsin in the duodenum. This study demonstrates that secretion of ingobsin from the proximal duodenum is exocrine and can be stimulated by VIP and acetylcholine.
KW - Acetylcholine
KW - Animals
KW - Duodenum
KW - Intestinal Secretions
KW - Male
KW - Rats
KW - Rats, Inbred Strains
KW - Serine Endopeptidases
KW - Vasoactive Intestinal Peptide
M3 - Journal article
C2 - 3479368
VL - 37
SP - 223
EP - 227
JO - Digestion
JF - Digestion
SN - 0012-2823
IS - 4
ER -
ID: 47488755