Overconsumption and obesity: peptides and susceptibility to weight gain
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Overconsumption and obesity : peptides and susceptibility to weight gain. / Blundell, J E; Levin, F; King, N A; Barkeling, B; Gustafsson, T; Gustafson, T; Hellstrom, P M; Holst, Jens Juul; Naslund, E.
I: Regulatory Peptides, Bind 149, Nr. 1-3, 07.08.2008, s. 32-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Overconsumption and obesity
T2 - peptides and susceptibility to weight gain
AU - Blundell, J E
AU - Levin, F
AU - King, N A
AU - Barkeling, B
AU - Gustafsson, T
AU - Gustafson, T
AU - Hellstrom, P M
AU - Holst, Jens Juul
AU - Naslund, E
PY - 2008/8/7
Y1 - 2008/8/7
N2 - Physiological control of feeding is mediated by tonic and episodic signalling systems. These are sometimes thought of as long-term and short-term control. Tonic signals arise from tissue stores whereas episodic signals oscillate periodically with the consumption of food. These physiological controls are paralleled in the motivation to eat by long-acting enduring traits (such as disinhibition) and by short-acting states (such as hunger). Peptides are usually envisaged to exert an action on appetite control through the modulation of states such as hunger and satiety (fullness). Here we provide evidence that peptides involved in tonic regulation--such as leptin--may express a control over appetite motivation through an effect on traits that confer a constant readiness to eat, whereas episodic peptides such as GLP-1 influence appetite motivation through a state such as hunger. The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain.
AB - Physiological control of feeding is mediated by tonic and episodic signalling systems. These are sometimes thought of as long-term and short-term control. Tonic signals arise from tissue stores whereas episodic signals oscillate periodically with the consumption of food. These physiological controls are paralleled in the motivation to eat by long-acting enduring traits (such as disinhibition) and by short-acting states (such as hunger). Peptides are usually envisaged to exert an action on appetite control through the modulation of states such as hunger and satiety (fullness). Here we provide evidence that peptides involved in tonic regulation--such as leptin--may express a control over appetite motivation through an effect on traits that confer a constant readiness to eat, whereas episodic peptides such as GLP-1 influence appetite motivation through a state such as hunger. The distinction between tonic and episodic regulation, and between traits and states has implications for understanding overconsumption and the susceptibility to weight gain.
KW - Appetite
KW - Female
KW - Humans
KW - Models, Biological
KW - Obesity
KW - Peptides
KW - Weight Gain
U2 - 10.1016/j.regpep.2007.10.009
DO - 10.1016/j.regpep.2007.10.009
M3 - Journal article
C2 - 18534696
VL - 149
SP - 32
EP - 38
JO - Regulatory Peptides
JF - Regulatory Peptides
SN - 0167-0115
IS - 1-3
ER -
ID: 132049015