MicroRNA-regulated non-viral vectors with improved tumor specificity in an orthotopic rat model of hepatocellular carcinoma
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
In hepatocellular carcinoma (HCC), tumor specificity of gene therapy is of utmost importance to preserve liver function. MicroRNAs (miRNAs) are powerful negative regulators of gene expression and many are downregulated in human HCC. We identified seven miRNAs that are also downregulated in tumors in a rat hepatoma model (P
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Gene Therapy |
| Vol/bind | 20 |
| Sider (fra-til) | 1006-1013 |
| Antal sider | 8 |
| ISSN | 0969-7128 |
| DOI | |
| Status | Udgivet - 30 maj 2013 |
ID: 47315946