Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour

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Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour. / Schou, M; Brünner, N; Spang-Thomsen, M; Rygaard, J.

I: Acta Pathologica Microbiologica et Immunologica Scandinavica, Bind 114, Nr. 12, 2006, s. 899-907.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schou, M, Brünner, N, Spang-Thomsen, M & Rygaard, J 2006, 'Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour', Acta Pathologica Microbiologica et Immunologica Scandinavica, bind 114, nr. 12, s. 899-907. https://doi.org/10.1111/j.1600-0463.2006.apm_546.x

APA

Schou, M., Brünner, N., Spang-Thomsen, M., & Rygaard, J. (2006). Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour. Acta Pathologica Microbiologica et Immunologica Scandinavica, 114(12), 899-907. https://doi.org/10.1111/j.1600-0463.2006.apm_546.x

Vancouver

Schou M, Brünner N, Spang-Thomsen M, Rygaard J. Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour. Acta Pathologica Microbiologica et Immunologica Scandinavica. 2006;114(12):899-907. https://doi.org/10.1111/j.1600-0463.2006.apm_546.x

Author

Schou, M ; Brünner, N ; Spang-Thomsen, M ; Rygaard, J. / Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour. I: Acta Pathologica Microbiologica et Immunologica Scandinavica. 2006 ; Bind 114, Nr. 12. s. 899-907.

Bibtex

@article{3731955064b811de8bc9000ea68e967b,
title = "Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour",
abstract = "Most nude mice do not allow the formation of metastases after heterotransplantation of human malignant tumours. Here we describe a substrain of BALB/c nude mice (BALB/c/AnNCr) that reproducibly allows some human cancers to metastasize. By Mendelian analysis of hybrids between this substrain and C57BL/6J +/+ mice we found that the ability to allow a human tumour (MDA-MB-435 BAG) to express its metastatic phenotype is determined by a recessively inheritable trait in the mouse host. We are presently working to identify the genetics responsible for development of metastases. The study also includes immunohistochemical and electron microscopic analysis of the test tumour, originally assumed to be a human mammary carcinoma, but shown to possess characteristics of a malignant melanoma (1). The ultimate aim of our ongoing study is to establish a substrain of nude mice that will allow metastasis in all recipients.",
author = "M Schou and N Br{\"u}nner and M Spang-Thomsen and J Rygaard",
note = "Keywords: Animals; Breast Neoplasms; Crosses, Genetic; Disease Models, Animal; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Pilot Projects; Transplantation, Heterologous",
year = "2006",
doi = "10.1111/j.1600-0463.2006.apm_546.x",
language = "English",
volume = "114",
pages = "899--907",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "12",

}

RIS

TY - JOUR

T1 - Mendelian analysis of a metastasis-prone substrain of BALB/c nude mice using a subcutaneously inoculated human tumour

AU - Schou, M

AU - Brünner, N

AU - Spang-Thomsen, M

AU - Rygaard, J

N1 - Keywords: Animals; Breast Neoplasms; Crosses, Genetic; Disease Models, Animal; Female; Humans; Immunohistochemistry; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Pilot Projects; Transplantation, Heterologous

PY - 2006

Y1 - 2006

N2 - Most nude mice do not allow the formation of metastases after heterotransplantation of human malignant tumours. Here we describe a substrain of BALB/c nude mice (BALB/c/AnNCr) that reproducibly allows some human cancers to metastasize. By Mendelian analysis of hybrids between this substrain and C57BL/6J +/+ mice we found that the ability to allow a human tumour (MDA-MB-435 BAG) to express its metastatic phenotype is determined by a recessively inheritable trait in the mouse host. We are presently working to identify the genetics responsible for development of metastases. The study also includes immunohistochemical and electron microscopic analysis of the test tumour, originally assumed to be a human mammary carcinoma, but shown to possess characteristics of a malignant melanoma (1). The ultimate aim of our ongoing study is to establish a substrain of nude mice that will allow metastasis in all recipients.

AB - Most nude mice do not allow the formation of metastases after heterotransplantation of human malignant tumours. Here we describe a substrain of BALB/c nude mice (BALB/c/AnNCr) that reproducibly allows some human cancers to metastasize. By Mendelian analysis of hybrids between this substrain and C57BL/6J +/+ mice we found that the ability to allow a human tumour (MDA-MB-435 BAG) to express its metastatic phenotype is determined by a recessively inheritable trait in the mouse host. We are presently working to identify the genetics responsible for development of metastases. The study also includes immunohistochemical and electron microscopic analysis of the test tumour, originally assumed to be a human mammary carcinoma, but shown to possess characteristics of a malignant melanoma (1). The ultimate aim of our ongoing study is to establish a substrain of nude mice that will allow metastasis in all recipients.

U2 - 10.1111/j.1600-0463.2006.apm_546.x

DO - 10.1111/j.1600-0463.2006.apm_546.x

M3 - Journal article

C2 - 17207091

VL - 114

SP - 899

EP - 907

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 12

ER -

ID: 12869974