Loss of Function Studies in Mice and Genetic Association Link Receptor Protein Tyrosine Phosphatase a to Schizophrenia

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

  • Nagahide Takahashi
  • Karin Sandager Nielsen
  • Branko Aleksic
  • Steffen Petersen
  • Masashi Ikeda
  • Itaru Kushima
  • Nathalie Vacaresse
  • Hiroshi Ujike
  • Nakao Iwata
  • Véronique Dubreuil
  • Naheed Mirza
  • Takeshi Sakurai
  • Norio Ozaki
  • Joseph D Buxbaum
  • Jan Sap
Solid evidence links schizophrenia (SZ) susceptibility to neurodevelopmental processes involving tyrosine phosphorylation-mediated signaling. Mouse studies implicate the Ptpra gene, encoding protein tyrosine phosphatase RPTPa, in the control of radial neuronal migration, cortical cytoarchitecture, and oligodendrocyte differentiation. The human gene encoding RPTPa, PTPRA, maps to a chromosomal region (20p13) associated with susceptibility to psychotic illness.
OriginalsprogEngelsk
TidsskriftBiological Psychiatry
Vol/bind70
Udgave nummer7
Sider (fra-til)626-35
Antal sider10
ISSN0006-3223
DOI
StatusUdgivet - 1 okt. 2011

ID: 34456635