TY - JOUR

T1 - Lithium transport across biological membranes.

AU - Holstein-Rathlou, N H

N1 - Keywords: Absorption; Animals; Biological Transport; Epithelium; Erythrocytes; Humans; Intestines; Kidney Tubules; Lithium; Permeability; Skin; Sodium

PY - 1990

Y1 - 1990

N2 - Li+ is actively transported out of cells, and across different epithelia of both mammalian and amphibian origin. Due to the low affinity of the Na+/K(+)-ATPase for Li+, the transport is most likely energized by exchange and/or cotransport processes. The detailed mechanism by which Li+ is reabsorbed across the proximal tubule is not known, although it seems reasonable to assume that at least a part is by secondary active transcellular transport. The evidence further suggest that aldosterone and maybe vasopressin, through their effects on the Na+ channels in the late distal tubule and the collecting duct may be of significance in inducing distal Li+ reabsorption, as seen during severe sodium restriction in rats and dogs. Clearly more studies are needed to finally resolve these issues.

AB - Li+ is actively transported out of cells, and across different epithelia of both mammalian and amphibian origin. Due to the low affinity of the Na+/K(+)-ATPase for Li+, the transport is most likely energized by exchange and/or cotransport processes. The detailed mechanism by which Li+ is reabsorbed across the proximal tubule is not known, although it seems reasonable to assume that at least a part is by secondary active transcellular transport. The evidence further suggest that aldosterone and maybe vasopressin, through their effects on the Na+ channels in the late distal tubule and the collecting duct may be of significance in inducing distal Li+ reabsorption, as seen during severe sodium restriction in rats and dogs. Clearly more studies are needed to finally resolve these issues.

M3 - Journal article

C2 - 2182930

VL - 28

SP - S4-9

JO - Kidney International. Supplement

JF - Kidney International. Supplement

SN - 0098-6577

ER -