Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.

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Standard

Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype. / Breau, Marie A; Pietri, Thomas; Eder, Olivier; Blanche, Martine; Brakebusch, Cord; Fässler, Reinhardt; Thiery, Jean P; Dufour, Sylvie.

I: Development, Bind 133, Nr. 9, 2006, s. 1725-34.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Breau, MA, Pietri, T, Eder, O, Blanche, M, Brakebusch, C, Fässler, R, Thiery, JP & Dufour, S 2006, 'Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.', Development, bind 133, nr. 9, s. 1725-34. https://doi.org/10.1242/dev.02346

APA

Breau, M. A., Pietri, T., Eder, O., Blanche, M., Brakebusch, C., Fässler, R., Thiery, J. P., & Dufour, S. (2006). Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype. Development, 133(9), 1725-34. https://doi.org/10.1242/dev.02346

Vancouver

Breau MA, Pietri T, Eder O, Blanche M, Brakebusch C, Fässler R o.a. Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype. Development. 2006;133(9):1725-34. https://doi.org/10.1242/dev.02346

Author

Breau, Marie A ; Pietri, Thomas ; Eder, Olivier ; Blanche, Martine ; Brakebusch, Cord ; Fässler, Reinhardt ; Thiery, Jean P ; Dufour, Sylvie. / Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype. I: Development. 2006 ; Bind 133, Nr. 9. s. 1725-34.

Bibtex

@article{74500160589311dd8d9f000ea68e967b,
title = "Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.",
abstract = "The enteric nervous system arises mainly from vagal and sacral neural crest cells that colonise the gut between 9.5 and 14 days of development in mice. Using the Cre-LoxP system, we removed beta1 integrins in the neural crest cells when they emerge from the neural tube. beta1-null enteric neural crest cells fail to colonise the gut completely, leading to an aganglionosis of the descending colon, which resembles the human Hirschsprung's disease. Moreover, beta1-null enteric neural crest cells form abnormal aggregates in the gut wall, leading to a severe alteration of the ganglia network organisation. Organotypic cultures of gut explants reveal that beta1-null enteric neural crest cells show impaired adhesion on extracellular matrix and enhanced intercellular adhesion properties. They display migration defects in collagen gels and gut tissue environments. We also provide evidence that beta1 integrins are required for the villi innervation in the small intestine. Our findings highlight the crucial roles played by beta1 integrins at various steps of enteric nervous system development.",
author = "Breau, {Marie A} and Thomas Pietri and Olivier Eder and Martine Blanche and Cord Brakebusch and Reinhardt F{\"a}ssler and Thiery, {Jean P} and Sylvie Dufour",
note = "Keywords: Animals; Antigens, CD29; Disease Models, Animal; Enteric Nervous System; Hirschsprung Disease; Immunohistochemistry; Integrases; Mice; Models, Genetic; Mutation; Neural Crest; Organ Culture Techniques; Phenotype; Viral Proteins",
year = "2006",
doi = "10.1242/dev.02346",
language = "English",
volume = "133",
pages = "1725--34",
journal = "Development",
issn = "0950-1991",
publisher = "The Company of Biologists",
number = "9",

}

RIS

TY - JOUR

T1 - Lack of beta1 integrins in enteric neural crest cells leads to a Hirschsprung-like phenotype.

AU - Breau, Marie A

AU - Pietri, Thomas

AU - Eder, Olivier

AU - Blanche, Martine

AU - Brakebusch, Cord

AU - Fässler, Reinhardt

AU - Thiery, Jean P

AU - Dufour, Sylvie

N1 - Keywords: Animals; Antigens, CD29; Disease Models, Animal; Enteric Nervous System; Hirschsprung Disease; Immunohistochemistry; Integrases; Mice; Models, Genetic; Mutation; Neural Crest; Organ Culture Techniques; Phenotype; Viral Proteins

PY - 2006

Y1 - 2006

N2 - The enteric nervous system arises mainly from vagal and sacral neural crest cells that colonise the gut between 9.5 and 14 days of development in mice. Using the Cre-LoxP system, we removed beta1 integrins in the neural crest cells when they emerge from the neural tube. beta1-null enteric neural crest cells fail to colonise the gut completely, leading to an aganglionosis of the descending colon, which resembles the human Hirschsprung's disease. Moreover, beta1-null enteric neural crest cells form abnormal aggregates in the gut wall, leading to a severe alteration of the ganglia network organisation. Organotypic cultures of gut explants reveal that beta1-null enteric neural crest cells show impaired adhesion on extracellular matrix and enhanced intercellular adhesion properties. They display migration defects in collagen gels and gut tissue environments. We also provide evidence that beta1 integrins are required for the villi innervation in the small intestine. Our findings highlight the crucial roles played by beta1 integrins at various steps of enteric nervous system development.

AB - The enteric nervous system arises mainly from vagal and sacral neural crest cells that colonise the gut between 9.5 and 14 days of development in mice. Using the Cre-LoxP system, we removed beta1 integrins in the neural crest cells when they emerge from the neural tube. beta1-null enteric neural crest cells fail to colonise the gut completely, leading to an aganglionosis of the descending colon, which resembles the human Hirschsprung's disease. Moreover, beta1-null enteric neural crest cells form abnormal aggregates in the gut wall, leading to a severe alteration of the ganglia network organisation. Organotypic cultures of gut explants reveal that beta1-null enteric neural crest cells show impaired adhesion on extracellular matrix and enhanced intercellular adhesion properties. They display migration defects in collagen gels and gut tissue environments. We also provide evidence that beta1 integrins are required for the villi innervation in the small intestine. Our findings highlight the crucial roles played by beta1 integrins at various steps of enteric nervous system development.

U2 - 10.1242/dev.02346

DO - 10.1242/dev.02346

M3 - Journal article

C2 - 16571628

VL - 133

SP - 1725

EP - 1734

JO - Development

JF - Development

SN - 0950-1991

IS - 9

ER -

ID: 5141034