Increased nuchal translucency thickness and risk of neurodevelopmental disorders
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Increased nuchal translucency thickness and risk of neurodevelopmental disorders. / Hellmuth, S G; Pedersen, L H; Miltoft, C B; Petersen, O B; Kjaergaard, S; Ekelund, Charlotte Kvist; Tabor, A.
I: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology, Bind 49, Nr. 5, 05.2017, s. 592-598.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased nuchal translucency thickness and risk of neurodevelopmental disorders
AU - Hellmuth, S G
AU - Pedersen, L H
AU - Miltoft, C B
AU - Petersen, O B
AU - Kjaergaard, S
AU - Ekelund, Charlotte Kvist
AU - Tabor, A
N1 - Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
PY - 2017/5
Y1 - 2017/5
N2 - OBJECTIVE: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children.METHODS: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95(th) percentile (n = 217 103 (97.6%)); NT 95(th) -99(th) percentile (n = 4760 (2.1%)); and NT > 99(th) percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries.RESULTS: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95(th) -99(th) percentile. For children with NT > 99(th) percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51-25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02-5.99), 0.78%) compared with children with NT < 95(th) percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61-5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63-3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44-1.16), 2.65%).CONCLUSIONS: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95(th) -99(th) percentile. Among euploid children with first-trimester NT > 99(th) percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%). Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
AB - OBJECTIVE: To investigate the association between fetal nuchal translucency (NT) thickness and neurodevelopmental disorders in euploid children.METHODS: This study included 222 505 euploid children who had undergone routine first-trimester screening during fetal life. Children were divided according to prenatal NT into three groups: NT < 95(th) percentile (n = 217 103 (97.6%)); NT 95(th) -99(th) percentile (n = 4760 (2.1%)); and NT > 99(th) percentile (n = 642 (0.3%)). All children were followed-up to a mean age of 4.4 years. Information on diagnoses of intellectual disability, autism spectrum disorders (ASD), cerebral palsy, epilepsy and febrile seizures was obtained from national patient registries.RESULTS: There was no excess risk of neurodevelopmental disorders among euploid children with first-trimester NT 95(th) -99(th) percentile. For children with NT > 99(th) percentile, there were increased risks of intellectual disability (odds ratio (OR), 6.16 (95% CI, 1.51-25.0), 0.31%) and ASD (OR, 2.48 (95% CI, 1.02-5.99), 0.78%) compared with children with NT < 95(th) percentile (incidence of 0.05% for intellectual disability and 0.32% for ASD), however, there was no detected increase in the risk of cerebral palsy (OR, 1.91 (95% CI, 0.61-5.95), 0.47%), epilepsy (OR, 1.51 (95% CI, 0.63-3.66), 0.78%) or febrile seizures (OR, 0.72 (95% CI, 0.44-1.16), 2.65%).CONCLUSIONS: In a large unselected cohort of euploid children, there was no increased risk of neurodevelopmental disorders among those with a first-trimester NT 95(th) -99(th) percentile. Among euploid children with first-trimester NT > 99(th) percentile, there were increased risks of intellectual disability and ASD, but the absolute risk was reassuringly low (< 1%). Copyright © 2016 ISUOG. Published by John Wiley & Sons Ltd.
KW - Adult
KW - Child, Preschool
KW - Chromosome Aberrations
KW - Denmark
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Infant
KW - Male
KW - Neurodevelopmental Disorders
KW - Nuchal Translucency Measurement
KW - Pregnancy
KW - Pregnancy Outcome
KW - Pregnancy Trimester, First
KW - Registries
KW - Risk Factors
KW - Journal Article
U2 - 10.1002/uog.15961
DO - 10.1002/uog.15961
M3 - Journal article
C2 - 27183961
VL - 49
SP - 592
EP - 598
JO - Ultrasound in Obstetrics and Gynecology
JF - Ultrasound in Obstetrics and Gynecology
SN - 0960-7692
IS - 5
ER -
ID: 185686848