Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
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Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. / Solomon, Thomas; Haus, Jacob M; Kelly, Karen R; Rocco, Michael; Kashyap, Sangeeta R; Kirwan, John P.
I: Diabetes Care, Bind 33, Nr. 7, 07.2010, s. 1561-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide
AU - Solomon, Thomas
AU - Haus, Jacob M
AU - Kelly, Karen R
AU - Rocco, Michael
AU - Kashyap, Sangeeta R
AU - Kirwan, John P
PY - 2010/7
Y1 - 2010/7
N2 - Restoration of insulin secretion is critical for the treatment of type 2 diabetes. Exercise and diet can alter glucose-induced insulin responses, but whether this is due to changes in beta-cell function per se is not clear. The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis.
AB - Restoration of insulin secretion is critical for the treatment of type 2 diabetes. Exercise and diet can alter glucose-induced insulin responses, but whether this is due to changes in beta-cell function per se is not clear. The mechanisms by which lifestyle intervention may modify insulin secretion in type 2 diabetes have also not been examined but may involve the incretin axis.
KW - Aged
KW - Blood Glucose
KW - Diabetes Mellitus, Type 2
KW - Diet, Reducing
KW - Exercise
KW - Female
KW - Gastric Inhibitory Polypeptide
KW - Glucose Clamp Technique
KW - Humans
KW - Hyperinsulinism
KW - Insulin
KW - Insulin Resistance
KW - Insulin-Secreting Cells
KW - Life Style
KW - Male
KW - Middle Aged
KW - Obesity
KW - Physical Fitness
KW - Weight Loss
U2 - 10.2337/dc09-2021
DO - 10.2337/dc09-2021
M3 - Journal article
C2 - 20200305
VL - 33
SP - 1561
EP - 1566
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 7
ER -
ID: 50218285