Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness
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Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness. / Jujic, Amra; Nilsson, Peter M.; Atabaki-Pasdar, Naeimeh; Dieden, Anna; Tuomi, Tiinamaija; Franks, Paul W.; Holst, Jens Juul; Torekov, Signe Sorensen; Ravassa, Susana; Diez, Javier; Persson, Margaretha; Ahlqvist, Emma; Melander, Olle; Gomez, Maria F.; Groop, Leif; Magnusson, Martin.
I: Diabetes Care, Bind 44, Nr. 1, 2021, s. 224-230.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glucose-Dependent Insulinotropic Peptide in the High-Normal Range Is Associated With Increased Carotid Intima-Media Thickness
AU - Jujic, Amra
AU - Nilsson, Peter M.
AU - Atabaki-Pasdar, Naeimeh
AU - Dieden, Anna
AU - Tuomi, Tiinamaija
AU - Franks, Paul W.
AU - Holst, Jens Juul
AU - Torekov, Signe Sorensen
AU - Ravassa, Susana
AU - Diez, Javier
AU - Persson, Margaretha
AU - Ahlqvist, Emma
AU - Melander, Olle
AU - Gomez, Maria F.
AU - Groop, Leif
AU - Magnusson, Martin
PY - 2021
Y1 - 2021
N2 - OBJECTIVE While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortality, and it was suggested that GIP plays a role in pathogenesis of coronary artery disease. We investigated the associations between fasting and postchallenge GIP and GLP-1 concentrations and subclinical atherosclerosis as measured by mean intima-media thickness in the common carotid artery (IMT(mean)CCA) and maximal intima-media thickness in the carotid bifurcation (IMT(max)Bulb). RESEARCH DESIGN AND METHODS Participants at reexamination within the Malmo Diet and Cancer-Cardiovascular Cohort study (n = 3,734, mean age 72.5 years, 59.3% women, 10.8% subjects with diabetes, fasting GIP available for 3,342 subjects, fasting GLP-1 available for 3,299 subjects) underwent oral glucose tolerance testing and carotid ultrasound. RESULTS In linear regression analyses, each 1-SD increment of fasting GIP was associated with increased (per mm) IMT(mean)CCA (beta = 0.010, P = 0.010) and IMT(max)Bulb (beta = 0.014; P = 0.040) in models adjusted for known risk factors and glucose metabolism. In contrast, each 1-SD increment of fasting GLP-1 was associated with decreased IMT(max)Bulb (per mm, beta = -0.016, P = 0.014). These associations remained significant when subjects with diabetes were excluded from analyses. CONCLUSIONS In a Swedish elderly population, physiologically elevated levels of fasting GIP are associated with increased IMT(mean)CCA, while GLP-1 is associated with decreased IMT(max)Bulb, further emphasizing diverging cardiovascular effects of these two incretin hormones.
AB - OBJECTIVE While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortality, and it was suggested that GIP plays a role in pathogenesis of coronary artery disease. We investigated the associations between fasting and postchallenge GIP and GLP-1 concentrations and subclinical atherosclerosis as measured by mean intima-media thickness in the common carotid artery (IMT(mean)CCA) and maximal intima-media thickness in the carotid bifurcation (IMT(max)Bulb). RESEARCH DESIGN AND METHODS Participants at reexamination within the Malmo Diet and Cancer-Cardiovascular Cohort study (n = 3,734, mean age 72.5 years, 59.3% women, 10.8% subjects with diabetes, fasting GIP available for 3,342 subjects, fasting GLP-1 available for 3,299 subjects) underwent oral glucose tolerance testing and carotid ultrasound. RESULTS In linear regression analyses, each 1-SD increment of fasting GIP was associated with increased (per mm) IMT(mean)CCA (beta = 0.010, P = 0.010) and IMT(max)Bulb (beta = 0.014; P = 0.040) in models adjusted for known risk factors and glucose metabolism. In contrast, each 1-SD increment of fasting GLP-1 was associated with decreased IMT(max)Bulb (per mm, beta = -0.016, P = 0.014). These associations remained significant when subjects with diabetes were excluded from analyses. CONCLUSIONS In a Swedish elderly population, physiologically elevated levels of fasting GIP are associated with increased IMT(mean)CCA, while GLP-1 is associated with decreased IMT(max)Bulb, further emphasizing diverging cardiovascular effects of these two incretin hormones.
KW - OSTEOPONTIN LEVELS
KW - ADIPOSE-TISSUE
KW - PLASMA OSTEOPONTIN
KW - RISK-FACTORS
KW - GIP
KW - EXPRESSION
KW - ATHEROSCLEROSIS
KW - RECEPTOR
KW - INFLAMMATION
U2 - 10.2337/dc20-1318
DO - 10.2337/dc20-1318
M3 - Journal article
C2 - 33208488
VL - 44
SP - 224
EP - 230
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 1
ER -
ID: 254662062