Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity. / Holst, Jens Juul.
I: Frontiers in Nutrition, Bind 9, 964406, 2022.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Glucagon and other proglucagon-derived peptides in the pathogenesis of obesity
AU - Holst, Jens Juul
N1 - Publisher Copyright: Copyright © 2022 Holst.
PY - 2022
Y1 - 2022
N2 - Because of differential processing of the hormone precursor, proglucagon, numerous peptide products are released from the pancreatic alpha cells and the intestinal L-cells in which the (pro)glucagon gene is expressed. Of particular interest in relation to obesity are glucagon from the pancreas and oxyntomodulin and GLP-1 from the gut, all of which inhibit food intake, but the other products are also briefly discussed, because knowledge about these is required for selection and evaluation of the methods for measurement of the hormones. The distal intestinal L-cells also secrete the appetite-inhibiting hormone PYY. Characteristics of the secretion of the pancreatic and intestinal products are described, and causes of the hypersecretion of glucagon in obesity and type 2 diabetes are discussed. In contrast, the secretion of the products of the L-cells is generally impaired in obesity, raising questions about their role in the development of obesity. It is concluded that the impairment probably is secondary to obesity, but the lower plasma levels may contribute to the development.
AB - Because of differential processing of the hormone precursor, proglucagon, numerous peptide products are released from the pancreatic alpha cells and the intestinal L-cells in which the (pro)glucagon gene is expressed. Of particular interest in relation to obesity are glucagon from the pancreas and oxyntomodulin and GLP-1 from the gut, all of which inhibit food intake, but the other products are also briefly discussed, because knowledge about these is required for selection and evaluation of the methods for measurement of the hormones. The distal intestinal L-cells also secrete the appetite-inhibiting hormone PYY. Characteristics of the secretion of the pancreatic and intestinal products are described, and causes of the hypersecretion of glucagon in obesity and type 2 diabetes are discussed. In contrast, the secretion of the products of the L-cells is generally impaired in obesity, raising questions about their role in the development of obesity. It is concluded that the impairment probably is secondary to obesity, but the lower plasma levels may contribute to the development.
KW - glicentin
KW - glucagon-like peptide-1 (GLP-1)
KW - gut hormones
KW - oxyntomodulin
KW - peptide YY
KW - proglucagon
U2 - 10.3389/fnut.2022.964406
DO - 10.3389/fnut.2022.964406
M3 - Review
C2 - 35990325
AN - SCOPUS:85136520668
VL - 9
JO - Frontiers in Nutrition
JF - Frontiers in Nutrition
SN - 2296-861X
M1 - 964406
ER -
ID: 319236445