Global longitudinal strain predicts atrial fibrillation in individuals without hypertension: A Community-based cohort study
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Global longitudinal strain predicts atrial fibrillation in individuals without hypertension : A Community-based cohort study. / Olsen, Flemming Javier; Biering-Sørensen, Sofie Reumert; Reimer Jensen, Anne Marie; Schnohr, Peter; Jensen, Gorm Boje; Svendsen, Jesper Hastrup; Møgelvang, Rasmus; Biering-Sørensen, Tor.
I: Clinical Research in Cardiology, Bind 110, 2021, s. 1801–1810.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Global longitudinal strain predicts atrial fibrillation in individuals without hypertension
T2 - A Community-based cohort study
AU - Olsen, Flemming Javier
AU - Biering-Sørensen, Sofie Reumert
AU - Reimer Jensen, Anne Marie
AU - Schnohr, Peter
AU - Jensen, Gorm Boje
AU - Svendsen, Jesper Hastrup
AU - Møgelvang, Rasmus
AU - Biering-Sørensen, Tor
N1 - Publisher Copyright: © 2021, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021
Y1 - 2021
N2 - Background: Global longitudinal strain (GLS) is a sensitive marker of myocardial dysfunction and atrial reservoir function. We sought to evaluate its value for predicting atrial fibrillation (AF) in the general population. Methods: Participants from the Copenhagen City Heart Study examined with echocardiography, including speckle tracking analyses, were included. The endpoint was AF obtained through national registries. Proportional hazards Cox regression was applied, including multivariable adjustments made for CHADS2 and CHARGE-AF risk factors. Abnormal GLS was defined as >—18%. Results: The data from 1,309 participants were analyzed. Of those, 153 (12%) developed AF during a median follow-up time of 15.9 years. The follow-up was 100%. The mean age was 57 years, 38% had hypertension, and GLS was − 18%. In unadjusted analysis, GLS was a univariable predictor of outcome (1.08 (1.04–1.13), p < 0.001, per 1% absolute decrease), but did not remain an independent predictor after adjusting for neither CHADS2 nor CHARGE-AF risk factors. However, hypertension modified the relationship between GLS and AF (p for interaction = 0.010), such that GLS only predicted AF in subjects without hypertension. In participants without hypertension, GLS remained an independent predictor of AF after adjusting for CHADS2 and CHARGE-AF (HR = 1.11 (1.03–1.20) and HR = 1.09 (1.01–1.19), respectively). In these participants, an abnormal GLS was associated with a more than twofold increased risk of AF (HR = 2.16 (1.26–3.72). The incidence rate was 3.17 and 6.81 per 1000 person-years for normal vs. abnormal GLS, respectively. Conclusion: Global longitudinal strain predicts AF in individuals without hypertension from the general population, independently of common risk scores. Graphical abstract: [Figure not available: see fulltext.]
AB - Background: Global longitudinal strain (GLS) is a sensitive marker of myocardial dysfunction and atrial reservoir function. We sought to evaluate its value for predicting atrial fibrillation (AF) in the general population. Methods: Participants from the Copenhagen City Heart Study examined with echocardiography, including speckle tracking analyses, were included. The endpoint was AF obtained through national registries. Proportional hazards Cox regression was applied, including multivariable adjustments made for CHADS2 and CHARGE-AF risk factors. Abnormal GLS was defined as >—18%. Results: The data from 1,309 participants were analyzed. Of those, 153 (12%) developed AF during a median follow-up time of 15.9 years. The follow-up was 100%. The mean age was 57 years, 38% had hypertension, and GLS was − 18%. In unadjusted analysis, GLS was a univariable predictor of outcome (1.08 (1.04–1.13), p < 0.001, per 1% absolute decrease), but did not remain an independent predictor after adjusting for neither CHADS2 nor CHARGE-AF risk factors. However, hypertension modified the relationship between GLS and AF (p for interaction = 0.010), such that GLS only predicted AF in subjects without hypertension. In participants without hypertension, GLS remained an independent predictor of AF after adjusting for CHADS2 and CHARGE-AF (HR = 1.11 (1.03–1.20) and HR = 1.09 (1.01–1.19), respectively). In these participants, an abnormal GLS was associated with a more than twofold increased risk of AF (HR = 2.16 (1.26–3.72). The incidence rate was 3.17 and 6.81 per 1000 person-years for normal vs. abnormal GLS, respectively. Conclusion: Global longitudinal strain predicts AF in individuals without hypertension from the general population, independently of common risk scores. Graphical abstract: [Figure not available: see fulltext.]
KW - Atrial fibrillation
KW - Echocardiography
KW - Speckle tracking
KW - Strain
U2 - 10.1007/s00392-021-01921-z
DO - 10.1007/s00392-021-01921-z
M3 - Journal article
C2 - 34406455
AN - SCOPUS:85112838949
VL - 110
SP - 1801
EP - 1810
JO - Clinical Research in Cardiology
JF - Clinical Research in Cardiology
SN - 1861-0684
ER -
ID: 276854438