Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein
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Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein. / Jeppesen, Troels E; Kristensen, Jesper B; Behrens, Carsten; Madsen, Jacob; Kjaer, Andreas.
I: Journal of Labelled Compounds and Radiopharmaceuticals, Bind 64, Nr. 5, 2021, s. 198-208.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fluorine-18 labeled aldehydes as prosthetic groups for oxime coupling with a FVIIa protein
AU - Jeppesen, Troels E
AU - Kristensen, Jesper B
AU - Behrens, Carsten
AU - Madsen, Jacob
AU - Kjaer, Andreas
N1 - © 2020 John Wiley & Sons, Ltd.
PY - 2021
Y1 - 2021
N2 - New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.
AB - New 18 F-labeled nonvolatile aldehyde prosthetic groups derived from [18 F]F-Py-TFP and spirocyclic iodonium (III)ylide precursors for late stage 18 F-labeling were developed. These precursors were characterized, 18 F-labeled, and compared in reactivity for oxime coupling. Oxime coupling was performed on an amino-oxy modified inhibited factor VII (FVIIai-ONH2 ) in low concentration to prove the applicability of the proposed method.
U2 - 10.1002/jlcr.3900
DO - 10.1002/jlcr.3900
M3 - Journal article
C2 - 33314295
VL - 64
SP - 198
EP - 208
JO - Journal of Labelled Compounds and Radiopharmaceuticals
JF - Journal of Labelled Compounds and Radiopharmaceuticals
SN - 0362-4803
IS - 5
ER -
ID: 256518381