Extracellular matrix turnover proteins as risk markers in people with type 2 diabetes and microalbuminuria

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Background
This post-hoc study investigated whether biomarkers reflecting extracellular matrix (ECM) turnover predicted cardiovascular disease (CVD), mortality, and progression of diabetic kidney disease (DKD) in individuals with type 2 diabetes (T2D) and microalbuminuria.

Methods
Serum levels of specific ECM turnover biomarkers were assessed in 192 participants with T2D and microalbuminuria from an observational study conducted at Steno Diabetes Center Copenhagen from 2007 to 2008. Endpoints included CVD events, mortality, and DKD progression, defined as decline in estimated glomerular filtration rate (eGFR) of >30 %.

Results
Participants had a mean age of 59 years, with 75 % males. Over a median follow-up of 4.9 to 6.3 years, the study recorded 38 CVD events, 24 deaths, and 40 DKD events. Elevated levels of a degradation fragment of collagen type I (C1M) were associated with an increased risk of >30 % eGFR decline, although this association was not independent of other risk factors. No significant associations were found between other ECM turnover biomarkers and DKD progression, mortality, or CVD risk.

Conclusion
Elevated C1M levels were linked to DKD progression in individuals with T2D and microalbuminuria, but not independently of other risk factors. None of the ECM turnover biomarkers were associated with CVD or mortality.
OriginalsprogEngelsk
Artikelnummer108765
TidsskriftJournal of Diabetes and its Complications
Vol/bind38
Udgave nummer6
Antal sider6
ISSN1056-8727
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
We thank all participants and acknowledge the work of study nurse Lone Jelstrup and lab technicians Anne G. Lundgaard, Berit R. Jensen, Tina R. Juhl, and Jessie A. Hermann, employees at Steno Diabetes Center Copenhagen and lab technician, Bibi Kamall, employee at Nordic Bioscience.

Publisher Copyright:
© 2024 Elsevier Inc.

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