Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine

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Standard

Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine. / Poulsen, Steen Seier.

I: Regulatory Peptides, Bind 7, Nr. 4, 12.1983, s. 367-72.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, SS 1983, 'Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine', Regulatory Peptides, bind 7, nr. 4, s. 367-72.

APA

Poulsen, S. S. (1983). Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine. Regulatory Peptides, 7(4), 367-72.

Vancouver

Poulsen SS. Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine. Regulatory Peptides. 1983 dec.;7(4):367-72.

Author

Poulsen, Steen Seier. / Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine. I: Regulatory Peptides. 1983 ; Bind 7, Nr. 4. s. 367-72.

Bibtex

@article{853e82bcd283477191d0d4a06b94be51,
title = "Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine",
abstract = "Brunner's glands of the duodenum are innervated by cholinergic and VIP-ergic nerves, and the glands have been shown to contain epidermal growth factor (EGF). In this study the effect of VIP and acetylcholine (Ach) on secretion of EGF from Brunner's glands was investigated in the rat. Intravenous infusion of VIP stimulated the flow rate of duodenal secretion, an effect which was inhibited by atropine. Ach alone did not significantly increase flow rate, and combined infusion of VIP and Ach induced the same flow as VIP alone. Concentration of EGF in duodenal secretion was increased by infusion of Ach, and this effect was potentiated by VIP. Infusion of VIP alone did not influence EGF concentration. EGF output from Brunner's glands was significantly stimulated by i.v. infusion of VIP and of Ach and combined infusion further increased EGF output. The study has demonstrated exocrine secretion of EGF from Brunner's glands, and it is suggested that stimulation is mediated by interaction of neuronal VIP and Ach.",
keywords = "Acetylcholine, Animals, Atropine, Brunner Glands, Drug Synergism, Duodenum, Epidermal Growth Factor, Male, Rats, Rats, Inbred Strains, Stimulation, Chemical, Vasoactive Intestinal Peptide",
author = "Poulsen, {Steen Seier}",
year = "1983",
month = dec,
language = "English",
volume = "7",
pages = "367--72",
journal = "Regulatory Peptides",
issn = "0167-0115",
publisher = "Elsevier",
number = "4",

}

RIS

TY - JOUR

T1 - Exocrine secretion of epidermal growth factor from Brunner's glands. Stimulation by VIP and acetylcholine

AU - Poulsen, Steen Seier

PY - 1983/12

Y1 - 1983/12

N2 - Brunner's glands of the duodenum are innervated by cholinergic and VIP-ergic nerves, and the glands have been shown to contain epidermal growth factor (EGF). In this study the effect of VIP and acetylcholine (Ach) on secretion of EGF from Brunner's glands was investigated in the rat. Intravenous infusion of VIP stimulated the flow rate of duodenal secretion, an effect which was inhibited by atropine. Ach alone did not significantly increase flow rate, and combined infusion of VIP and Ach induced the same flow as VIP alone. Concentration of EGF in duodenal secretion was increased by infusion of Ach, and this effect was potentiated by VIP. Infusion of VIP alone did not influence EGF concentration. EGF output from Brunner's glands was significantly stimulated by i.v. infusion of VIP and of Ach and combined infusion further increased EGF output. The study has demonstrated exocrine secretion of EGF from Brunner's glands, and it is suggested that stimulation is mediated by interaction of neuronal VIP and Ach.

AB - Brunner's glands of the duodenum are innervated by cholinergic and VIP-ergic nerves, and the glands have been shown to contain epidermal growth factor (EGF). In this study the effect of VIP and acetylcholine (Ach) on secretion of EGF from Brunner's glands was investigated in the rat. Intravenous infusion of VIP stimulated the flow rate of duodenal secretion, an effect which was inhibited by atropine. Ach alone did not significantly increase flow rate, and combined infusion of VIP and Ach induced the same flow as VIP alone. Concentration of EGF in duodenal secretion was increased by infusion of Ach, and this effect was potentiated by VIP. Infusion of VIP alone did not influence EGF concentration. EGF output from Brunner's glands was significantly stimulated by i.v. infusion of VIP and of Ach and combined infusion further increased EGF output. The study has demonstrated exocrine secretion of EGF from Brunner's glands, and it is suggested that stimulation is mediated by interaction of neuronal VIP and Ach.

KW - Acetylcholine

KW - Animals

KW - Atropine

KW - Brunner Glands

KW - Drug Synergism

KW - Duodenum

KW - Epidermal Growth Factor

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Stimulation, Chemical

KW - Vasoactive Intestinal Peptide

M3 - Journal article

C2 - 6608121

VL - 7

SP - 367

EP - 372

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - 4

ER -

ID: 47489382