Exercise-induced changes in left ventricular strain are affected by interleukin-6 activity: An exploratory analysis of a randomised-controlled trial in humans with abdominal obesity
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Exercise-induced changes in left ventricular strain are affected by interleukin-6 activity : An exploratory analysis of a randomised-controlled trial in humans with abdominal obesity. / Jønck, Simon; Løk, Mathilde; Durrer, Cody; Wedell-Neergaard, Anne Sophie; Lehrskov, Louise Lang; Legaard, Grit Elster; Krogh-Madsen, Rikke; Rosenmeier, Jaya; Lund, Morten Asp Vonsild; Pedersen, Bente Klarlund; Ellingsgaard, Helga; Berg, Ronan M.G.; Christensen, Regitse Højgaard.
I: Experimental Physiology, 2024.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Exercise-induced changes in left ventricular strain are affected by interleukin-6 activity
T2 - An exploratory analysis of a randomised-controlled trial in humans with abdominal obesity
AU - Jønck, Simon
AU - Løk, Mathilde
AU - Durrer, Cody
AU - Wedell-Neergaard, Anne Sophie
AU - Lehrskov, Louise Lang
AU - Legaard, Grit Elster
AU - Krogh-Madsen, Rikke
AU - Rosenmeier, Jaya
AU - Lund, Morten Asp Vonsild
AU - Pedersen, Bente Klarlund
AU - Ellingsgaard, Helga
AU - Berg, Ronan M.G.
AU - Christensen, Regitse Højgaard
N1 - Publisher Copyright: © 2024 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
PY - 2024
Y1 - 2024
N2 - Whilst the exercise-induced myokine interleukin-6 (IL-6) plays a beneficial role in cardiac structural adaptations, its influence on exercise-induced functional cardiac outcomes remains unknown. We hypothesised that IL-6 activity is required for exercise-induced improvements in left ventricular global longitudinal strain (LV GLS). In an exploratory study 52 individuals with abdominal obesity were randomised to 12 weeks’ high-intensity exercise or no exercise in combination with IL-6 receptor inhibition (IL-6i) or placebo. LV strain and volume measurements were assessed by cardiac magnetic resonance. Exercise improved LV GLS by −5.4% [95% CI: −9.1% to −1.6%] (P = 0.007). Comparing the change from baseline in LV GLS in the exercise + placebo group (−4.8% [95% CI: −7.4% to −2.2%]; P < 0.0004) to the exercise + IL-6i group (−1.1% [95% CI: −3.8% to 1.6%]; P = 0.42), the exercise + placebo group changed −3.7% [95% CI: −7.4% to −0.02%] (P = 0.049) more than the exercise + IL6i group. However, the interaction effect between exercise and IL-6i was insignificant (4.5% [95% CI: −0.8% to 9.9%]; P = 0.09). Similarly, the exercise + placebo group improved LV global circumferential strain by −3.1% [95% CI: −6.0% to −0.1%] (P = 0.04) more compared to the exercise + IL-6i group, yet we found an insignificant interaction between exercise and IL-6i (4.2% [95% CI: −1.8% to 10.3%]; P = 0.16). There was no effect of IL-6i on exercise-induced changes to volume rates. This study underscores the importance of IL-6 in improving LV GLS in individuals with abdominal obesity suggesting a role for IL-6 in cardiac functional exercise adaptations.
AB - Whilst the exercise-induced myokine interleukin-6 (IL-6) plays a beneficial role in cardiac structural adaptations, its influence on exercise-induced functional cardiac outcomes remains unknown. We hypothesised that IL-6 activity is required for exercise-induced improvements in left ventricular global longitudinal strain (LV GLS). In an exploratory study 52 individuals with abdominal obesity were randomised to 12 weeks’ high-intensity exercise or no exercise in combination with IL-6 receptor inhibition (IL-6i) or placebo. LV strain and volume measurements were assessed by cardiac magnetic resonance. Exercise improved LV GLS by −5.4% [95% CI: −9.1% to −1.6%] (P = 0.007). Comparing the change from baseline in LV GLS in the exercise + placebo group (−4.8% [95% CI: −7.4% to −2.2%]; P < 0.0004) to the exercise + IL-6i group (−1.1% [95% CI: −3.8% to 1.6%]; P = 0.42), the exercise + placebo group changed −3.7% [95% CI: −7.4% to −0.02%] (P = 0.049) more than the exercise + IL6i group. However, the interaction effect between exercise and IL-6i was insignificant (4.5% [95% CI: −0.8% to 9.9%]; P = 0.09). Similarly, the exercise + placebo group improved LV global circumferential strain by −3.1% [95% CI: −6.0% to −0.1%] (P = 0.04) more compared to the exercise + IL-6i group, yet we found an insignificant interaction between exercise and IL-6i (4.2% [95% CI: −1.8% to 10.3%]; P = 0.16). There was no effect of IL-6i on exercise-induced changes to volume rates. This study underscores the importance of IL-6 in improving LV GLS in individuals with abdominal obesity suggesting a role for IL-6 in cardiac functional exercise adaptations.
KW - cardiac adaptations
KW - exercise
KW - interleukin-6
UR - http://www.scopus.com/inward/record.url?scp=85194529771&partnerID=8YFLogxK
U2 - 10.1113/EP091800
DO - 10.1113/EP091800
M3 - Journal article
C2 - 38803062
AN - SCOPUS:85194529771
JO - Experimental Physiology
JF - Experimental Physiology
SN - 0958-0670
ER -
ID: 394708038