Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses
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Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses. / Trachsel, Dagmar S; Calloe, Kirstine; J Rgensen, Elin; Lunddahl, Christine S; Pedersen, Philip J; Kanters, J Rgen K; Klaerke, Dan A; Buhl, Rikke.
I: American Journal of Veterinary Research, Bind 82, Nr. 3, 2021, s. 207-217.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of electrocardiographic repolarization parameters after administration of trimethoprim-sulfadiazine, detomidine, or their combination in horses
AU - Trachsel, Dagmar S
AU - Calloe, Kirstine
AU - J Rgensen, Elin
AU - Lunddahl, Christine S
AU - Pedersen, Philip J
AU - Kanters, J Rgen K
AU - Klaerke, Dan A
AU - Buhl, Rikke
PY - 2021
Y1 - 2021
N2 - OBJECTIVE: To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses.ANIMALS: 9 healthy adult horses.PROCEDURES: Each horse received 4 treatments in a blinded, randomized, crossover study design as follows: TMS, 16 to 24 mg/kg, IV; DET, 0.015 to 0.02 mg/kg, IV; TMS plus DET; and saline (0.9% NaCl) solution. Surface ECG traces were obtained over 24 hours, and repolarization parameters were measured at predefined time points after each treatment and compared with a 2-way ANOVA for repeated measures.RESULTS: Heart rate-corrected QT intervals (QTc) were significantly increased after administration of DET (mean ± SD difference in QTc, 36.57 ± 23.07 milliseconds; increase of 7%) and TMS plus DET (44.96 ± 29.16 milliseconds; increase of 9%), compared with baseline (before treatment) values and values after administration of saline solution. Saline solution and TMS alone did not affect QTc.CONCLUSIONS AND CLINICAL RELEVANCE: Administration of DET or TMS plus DET was associated with a significant and possibly clinically relevant prolongation of QTc, with prolongation of 7% to 9%, a range that is considered as a risk factor for the development of cardiac arrhythmias in people. Results were unexpected because DET is considered to be a safe sedative for horses.
AB - OBJECTIVE: To determine whether administration of trimethoprim-sulfadiazine (TMS), detomidine (DET), or TMS plus DET would be associated with changes in ECG repolarization parameters in horses.ANIMALS: 9 healthy adult horses.PROCEDURES: Each horse received 4 treatments in a blinded, randomized, crossover study design as follows: TMS, 16 to 24 mg/kg, IV; DET, 0.015 to 0.02 mg/kg, IV; TMS plus DET; and saline (0.9% NaCl) solution. Surface ECG traces were obtained over 24 hours, and repolarization parameters were measured at predefined time points after each treatment and compared with a 2-way ANOVA for repeated measures.RESULTS: Heart rate-corrected QT intervals (QTc) were significantly increased after administration of DET (mean ± SD difference in QTc, 36.57 ± 23.07 milliseconds; increase of 7%) and TMS plus DET (44.96 ± 29.16 milliseconds; increase of 9%), compared with baseline (before treatment) values and values after administration of saline solution. Saline solution and TMS alone did not affect QTc.CONCLUSIONS AND CLINICAL RELEVANCE: Administration of DET or TMS plus DET was associated with a significant and possibly clinically relevant prolongation of QTc, with prolongation of 7% to 9%, a range that is considered as a risk factor for the development of cardiac arrhythmias in people. Results were unexpected because DET is considered to be a safe sedative for horses.
KW - Animals
KW - Cross-Over Studies
KW - Electrocardiography/veterinary
KW - Heart Rate
KW - Horses
KW - Imidazoles
KW - Sulfadiazine
KW - Trimethoprim/adverse effects
U2 - 10.2460/ajvr.82.3.207
DO - 10.2460/ajvr.82.3.207
M3 - Journal article
C2 - 33629897
VL - 82
SP - 207
EP - 217
JO - American Journal of Veterinary Research
JF - American Journal of Veterinary Research
SN - 0002-9645
IS - 3
ER -
ID: 258229335