Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz
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Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz. / Poulie, Christian B. M.; Jorgensen, Jesper T.; Shalgunov, Vladimir; Kougioumtzoglou, Georgios; Jeppesen, Troels Elmer; Kjaer, Andreas; Herth, Matthias M.
I: Molecules, Bind 26, Nr. 3, 544, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Evaluation of [Cu-64]Cu-NOTA-PEG7-H-Tz for Pretargeted Imaging in LS174T Xenografts-Comparison to [111In-111]In-DOTA-PEG11-BisPy-Tz
AU - Poulie, Christian B. M.
AU - Jorgensen, Jesper T.
AU - Shalgunov, Vladimir
AU - Kougioumtzoglou, Georgios
AU - Jeppesen, Troels Elmer
AU - Kjaer, Andreas
AU - Herth, Matthias M.
PY - 2021
Y1 - 2021
N2 - Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [Cu-64]Cu-NOTA-PEG(7)-H-Tz using a setup we previously used for [In-111]In-DOTA-PEG(11)-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison of the physicochemical properties of the compounds and their performance in an ex vivo blocking assay. Finally, [Cu-64]Cu-NOTA-PEG(7)-H-Tz was evaluated in a pretargeted imaging study and compared to [In-111]In-DOTA-PEG(11)-BisPy-Tz. Despite minor differences, this study indicated that both evaluated tetrazines are equally suited for pretargeted imaging.
AB - Pretargeted nuclear imaging for the diagnosis of various cancers is an emerging and fast developing field. The tetrazine ligation is currently considered the most promising reaction in this respect. Monoclonal antibodies are often the preferred choice as pretargeting vector due to their outstanding targeting properties. In this work, we evaluated the performance of [Cu-64]Cu-NOTA-PEG(7)-H-Tz using a setup we previously used for [In-111]In-DOTA-PEG(11)-BisPy-Tz, thereby allowing for comparison of the performance of these two promising pretargeting imaging agents. The evaluation included a comparison of the physicochemical properties of the compounds and their performance in an ex vivo blocking assay. Finally, [Cu-64]Cu-NOTA-PEG(7)-H-Tz was evaluated in a pretargeted imaging study and compared to [In-111]In-DOTA-PEG(11)-BisPy-Tz. Despite minor differences, this study indicated that both evaluated tetrazines are equally suited for pretargeted imaging.
KW - tetrazine
KW - pretargeted imaging
KW - radiochemistry
KW - PET
KW - SPECT
KW - cancer
U2 - 10.3390/molecules26030544
DO - 10.3390/molecules26030544
M3 - Journal article
C2 - 33494416
VL - 26
JO - Molecules (Print Archive Edition)
JF - Molecules (Print Archive Edition)
SN - 1431-5157
IS - 3
M1 - 544
ER -
ID: 261070294