Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials

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Standard

Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. / Voldborg, B R; Damstrup, L; Spang-Thomsen, M; Poulsen, H S.

I: Annals of Oncology, Bind 8, Nr. 12, 1997, s. 1197-206.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Voldborg, BR, Damstrup, L, Spang-Thomsen, M & Poulsen, HS 1997, 'Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials', Annals of Oncology, bind 8, nr. 12, s. 1197-206.

APA

Voldborg, B. R., Damstrup, L., Spang-Thomsen, M., & Poulsen, H. S. (1997). Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Annals of Oncology, 8(12), 1197-206.

Vancouver

Voldborg BR, Damstrup L, Spang-Thomsen M, Poulsen HS. Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. Annals of Oncology. 1997;8(12):1197-206.

Author

Voldborg, B R ; Damstrup, L ; Spang-Thomsen, M ; Poulsen, H S. / Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials. I: Annals of Oncology. 1997 ; Bind 8, Nr. 12. s. 1197-206.

Bibtex

@article{ec64264064b811de8bc9000ea68e967b,
title = "Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials",
abstract = "The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. The receptor is located at the cell surface, where the binding of a ligand activates a tyrosine kinase in the intracellular region of the receptor. This tyrosine kinase phosphorylates a number of intracellular substrates that activates pathways leading to cell growth, DNA synthesis and the expression of oncogenes such as fos and jun. EGFR is thought to be involved the development of cancer, as the EGFR gene is often amplified, and/or mutated in cancer cells. In this review we will focus on: (I) the structure and function of EGFR, (II) implications of receptor/ligand coexpression and EGFR mutations or overexpression, (III) its effect on cancer cells, (IV) the development of the malignant phenotype and (V) the clinical aspects of therapeutic targeting of EGFR.",
author = "Voldborg, {B R} and L Damstrup and M Spang-Thomsen and Poulsen, {H S}",
note = "Keywords: Clinical Trials as Topic; Gene Deletion; Humans; Mutation; Neoplasms; Phenotype; Receptor, Epidermal Growth Factor; Signal Transduction",
year = "1997",
language = "English",
volume = "8",
pages = "1197--206",
journal = "Annals of Oncology",
issn = "0923-7534",
publisher = "Oxford University Press",
number = "12",

}

RIS

TY - JOUR

T1 - Epidermal growth factor receptor (EGFR) and EGFR mutations, function and possible role in clinical trials

AU - Voldborg, B R

AU - Damstrup, L

AU - Spang-Thomsen, M

AU - Poulsen, H S

N1 - Keywords: Clinical Trials as Topic; Gene Deletion; Humans; Mutation; Neoplasms; Phenotype; Receptor, Epidermal Growth Factor; Signal Transduction

PY - 1997

Y1 - 1997

N2 - The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. The receptor is located at the cell surface, where the binding of a ligand activates a tyrosine kinase in the intracellular region of the receptor. This tyrosine kinase phosphorylates a number of intracellular substrates that activates pathways leading to cell growth, DNA synthesis and the expression of oncogenes such as fos and jun. EGFR is thought to be involved the development of cancer, as the EGFR gene is often amplified, and/or mutated in cancer cells. In this review we will focus on: (I) the structure and function of EGFR, (II) implications of receptor/ligand coexpression and EGFR mutations or overexpression, (III) its effect on cancer cells, (IV) the development of the malignant phenotype and (V) the clinical aspects of therapeutic targeting of EGFR.

AB - The epidermal growth factor receptor (EGFR) is a growth factor receptor that induces cell differentiation and proliferation upon activation through the binding of one of its ligands. The receptor is located at the cell surface, where the binding of a ligand activates a tyrosine kinase in the intracellular region of the receptor. This tyrosine kinase phosphorylates a number of intracellular substrates that activates pathways leading to cell growth, DNA synthesis and the expression of oncogenes such as fos and jun. EGFR is thought to be involved the development of cancer, as the EGFR gene is often amplified, and/or mutated in cancer cells. In this review we will focus on: (I) the structure and function of EGFR, (II) implications of receptor/ligand coexpression and EGFR mutations or overexpression, (III) its effect on cancer cells, (IV) the development of the malignant phenotype and (V) the clinical aspects of therapeutic targeting of EGFR.

M3 - Journal article

C2 - 9496384

VL - 8

SP - 1197

EP - 1206

JO - Annals of Oncology

JF - Annals of Oncology

SN - 0923-7534

IS - 12

ER -

ID: 12870095