Epidermal growth factor inhibits cysteamine-induced duodenal ulcers

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Standard

Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. / Poulsen, Steen Seier.

I: Gastroenterology, Bind 85, Nr. 6, 12.1983, s. 1277-83.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, SS 1983, 'Epidermal growth factor inhibits cysteamine-induced duodenal ulcers', Gastroenterology, bind 85, nr. 6, s. 1277-83.

APA

Poulsen, S. S. (1983). Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. Gastroenterology, 85(6), 1277-83.

Vancouver

Poulsen SS. Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. Gastroenterology. 1983 dec.;85(6):1277-83.

Author

Poulsen, Steen Seier. / Epidermal growth factor inhibits cysteamine-induced duodenal ulcers. I: Gastroenterology. 1983 ; Bind 85, Nr. 6. s. 1277-83.

Bibtex

@article{345e8d1abe1b488087e5d9c8eeda18a6,
title = "Epidermal growth factor inhibits cysteamine-induced duodenal ulcers",
abstract = "The effect of the duodenal ulcerogen cysteamine on secretion of epidermal growth factor from Brunner's gland pouches was studied in the rat. Total output of immunoreactive epidermal growth factor was reduced to approximately 55%, compared with controls, 5 h after administration of cysteamine (300 mg/kg, s.c.). Furthermore, measurements on tissue extracts of the pouches revealed that 5 h after cysteamine treatment, Brunner's glands were depleted of epidermal growth factor. The effect on ulcer development of intraduodenally applied exogenous epidermal growth factor (1 micrograms/kg . h) also was studied. Luminal epidermal growth factor significantly inhibited the formation of cysteamine-induced duodenal ulcer, compared with controls receiving saline. The effect was not due to inhibition of gastric acid secretion or stimulation of duodenal bicarbonate secretion since the dose of epidermal growth factor used, when tested on chronic fistula rats, had no effect on acid secretion and did not influence bicarbonate secretion from Brunner's gland pouches. These results demonstrate that epidermal growth factor has a cytoprotective effect on the duodenal mucosa, and it is suggested that inhibition of synthesis and secretion of endogenous epidermal growth factor may be a pathogenetic factor in cysteamine-induced duodenal ulcer.",
keywords = "Animals, Brunner Glands, Cysteamine, Duodenal Ulcer, Epidermal Growth Factor, Female, Rats, Rats, Inbred Strains",
author = "Poulsen, {Steen Seier}",
year = "1983",
month = dec,
language = "English",
volume = "85",
pages = "1277--83",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - Epidermal growth factor inhibits cysteamine-induced duodenal ulcers

AU - Poulsen, Steen Seier

PY - 1983/12

Y1 - 1983/12

N2 - The effect of the duodenal ulcerogen cysteamine on secretion of epidermal growth factor from Brunner's gland pouches was studied in the rat. Total output of immunoreactive epidermal growth factor was reduced to approximately 55%, compared with controls, 5 h after administration of cysteamine (300 mg/kg, s.c.). Furthermore, measurements on tissue extracts of the pouches revealed that 5 h after cysteamine treatment, Brunner's glands were depleted of epidermal growth factor. The effect on ulcer development of intraduodenally applied exogenous epidermal growth factor (1 micrograms/kg . h) also was studied. Luminal epidermal growth factor significantly inhibited the formation of cysteamine-induced duodenal ulcer, compared with controls receiving saline. The effect was not due to inhibition of gastric acid secretion or stimulation of duodenal bicarbonate secretion since the dose of epidermal growth factor used, when tested on chronic fistula rats, had no effect on acid secretion and did not influence bicarbonate secretion from Brunner's gland pouches. These results demonstrate that epidermal growth factor has a cytoprotective effect on the duodenal mucosa, and it is suggested that inhibition of synthesis and secretion of endogenous epidermal growth factor may be a pathogenetic factor in cysteamine-induced duodenal ulcer.

AB - The effect of the duodenal ulcerogen cysteamine on secretion of epidermal growth factor from Brunner's gland pouches was studied in the rat. Total output of immunoreactive epidermal growth factor was reduced to approximately 55%, compared with controls, 5 h after administration of cysteamine (300 mg/kg, s.c.). Furthermore, measurements on tissue extracts of the pouches revealed that 5 h after cysteamine treatment, Brunner's glands were depleted of epidermal growth factor. The effect on ulcer development of intraduodenally applied exogenous epidermal growth factor (1 micrograms/kg . h) also was studied. Luminal epidermal growth factor significantly inhibited the formation of cysteamine-induced duodenal ulcer, compared with controls receiving saline. The effect was not due to inhibition of gastric acid secretion or stimulation of duodenal bicarbonate secretion since the dose of epidermal growth factor used, when tested on chronic fistula rats, had no effect on acid secretion and did not influence bicarbonate secretion from Brunner's gland pouches. These results demonstrate that epidermal growth factor has a cytoprotective effect on the duodenal mucosa, and it is suggested that inhibition of synthesis and secretion of endogenous epidermal growth factor may be a pathogenetic factor in cysteamine-induced duodenal ulcer.

KW - Animals

KW - Brunner Glands

KW - Cysteamine

KW - Duodenal Ulcer

KW - Epidermal Growth Factor

KW - Female

KW - Rats

KW - Rats, Inbred Strains

M3 - Journal article

C2 - 6605273

VL - 85

SP - 1277

EP - 1283

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 6

ER -

ID: 47489573