Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands

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Standard

Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands. / Poulsen, Steen Seier.

I: Gut, Bind 25, Nr. 11, 11.1984, s. 1225-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Poulsen, SS 1984, 'Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands', Gut, bind 25, nr. 11, s. 1225-9.

APA

Poulsen, S. S. (1984). Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands. Gut, 25(11), 1225-9.

Vancouver

Poulsen SS. Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands. Gut. 1984 nov.;25(11):1225-9.

Author

Poulsen, Steen Seier. / Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands. I: Gut. 1984 ; Bind 25, Nr. 11. s. 1225-9.

Bibtex

@article{bd6483cfb0e04a18814e2418a1626238,
title = "Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands",
abstract = "The effect of VIP and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands was investigated in the rat. Vasoactive intestinal polypeptide infused in doses of 10 and 100 ng/kg/h significantly increased epidermal growth factor and bicarbonate output, but the concentrations did not change. Somatostatin infused at doses of 1, 10, 100 and 1000 ng/kg/h against a background of VIP 100 ng/kg/h inhibited in dose-dependent fashion the stimulated epidermal growth factor and bicarbonate outputs from rat Brunner's gland pouches. Also basal secretion was inhibited by somatostatin. Infusion of antisomatostatin serum stimulated Brunner's gland secretion. By immunohistochemical studies of rat duodena, it was found that epidermal growth factor, is almost exclusively present in the secretory cells of Brunner's glands. It is concluded that VIP stimulates secretion of epidermal growth factor and bicarbonate from Brunner's glands, an effect which is inhibited by somatostatin. A possible role for somatostatin in the control of Brunner's gland secretion is suggested.",
keywords = "Animals, Bicarbonates, Brunner Glands, Dose-Response Relationship, Drug, Duodenum, Epidermal Growth Factor, Intestinal Secretions, Male, Rats, Rats, Inbred Strains, Secretory Rate, Somatostatin, Vasoactive Intestinal Peptide",
author = "Poulsen, {Steen Seier}",
year = "1984",
month = nov,
language = "English",
volume = "25",
pages = "1225--9",
journal = "Gut",
issn = "0017-5749",
publisher = "B M J Group",
number = "11",

}

RIS

TY - JOUR

T1 - Effect of vasoactive intestinal polypeptide and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands

AU - Poulsen, Steen Seier

PY - 1984/11

Y1 - 1984/11

N2 - The effect of VIP and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands was investigated in the rat. Vasoactive intestinal polypeptide infused in doses of 10 and 100 ng/kg/h significantly increased epidermal growth factor and bicarbonate output, but the concentrations did not change. Somatostatin infused at doses of 1, 10, 100 and 1000 ng/kg/h against a background of VIP 100 ng/kg/h inhibited in dose-dependent fashion the stimulated epidermal growth factor and bicarbonate outputs from rat Brunner's gland pouches. Also basal secretion was inhibited by somatostatin. Infusion of antisomatostatin serum stimulated Brunner's gland secretion. By immunohistochemical studies of rat duodena, it was found that epidermal growth factor, is almost exclusively present in the secretory cells of Brunner's glands. It is concluded that VIP stimulates secretion of epidermal growth factor and bicarbonate from Brunner's glands, an effect which is inhibited by somatostatin. A possible role for somatostatin in the control of Brunner's gland secretion is suggested.

AB - The effect of VIP and somatostatin on secretion of epidermal growth factor and bicarbonate from Brunner's glands was investigated in the rat. Vasoactive intestinal polypeptide infused in doses of 10 and 100 ng/kg/h significantly increased epidermal growth factor and bicarbonate output, but the concentrations did not change. Somatostatin infused at doses of 1, 10, 100 and 1000 ng/kg/h against a background of VIP 100 ng/kg/h inhibited in dose-dependent fashion the stimulated epidermal growth factor and bicarbonate outputs from rat Brunner's gland pouches. Also basal secretion was inhibited by somatostatin. Infusion of antisomatostatin serum stimulated Brunner's gland secretion. By immunohistochemical studies of rat duodena, it was found that epidermal growth factor, is almost exclusively present in the secretory cells of Brunner's glands. It is concluded that VIP stimulates secretion of epidermal growth factor and bicarbonate from Brunner's glands, an effect which is inhibited by somatostatin. A possible role for somatostatin in the control of Brunner's gland secretion is suggested.

KW - Animals

KW - Bicarbonates

KW - Brunner Glands

KW - Dose-Response Relationship, Drug

KW - Duodenum

KW - Epidermal Growth Factor

KW - Intestinal Secretions

KW - Male

KW - Rats

KW - Rats, Inbred Strains

KW - Secretory Rate

KW - Somatostatin

KW - Vasoactive Intestinal Peptide

M3 - Journal article

C2 - 6149978

VL - 25

SP - 1225

EP - 1229

JO - Gut

JF - Gut

SN - 0017-5749

IS - 11

ER -

ID: 47489244