TY - JOUR

T1 - Effect of secretin and glucagon on Brunner's gland secretion in the rat

AU - Kirkegaard, P.

AU - Olsen, P. S.

AU - Poulsen, S. S.

PY - 1984/1/1

Y1 - 1984/1/1

N2 - Brunner's gland secretion in response to infusion of secretin and glucagon was studied in the rat. Secretin was infused in doses of 15, 150 and 1500 ng/kg/h. All doses significantly increased bicarbonate and protein output and depleted Brunner's glands of PAS-positive mucin. Bicarbonate secretion was related to plasma secretion concentration, and a marked stimulatory effect of secretin was found in very low, probably physiological, plasma concentrations. Maximal bicarbonate output was obtained at a plasma concentration of secretin about 20 pmol/l. Glucagon was infused at a rate of 1.0 μg/kg/h and did not influence secretion rate or cell morphology. Also large doses of 5.0 and 50.0 μg/kg/h had no effect on Brunner's gland secretion. It is concluded that secretin in very low plasma concentrations stimulates secretion of bicarbonate, protein and mucus from Brunner's glands in the rat, while glucagon has no effect, and it is suggested that secretin may be involved in the physiological regulation of Brunner's gland secretion.

AB - Brunner's gland secretion in response to infusion of secretin and glucagon was studied in the rat. Secretin was infused in doses of 15, 150 and 1500 ng/kg/h. All doses significantly increased bicarbonate and protein output and depleted Brunner's glands of PAS-positive mucin. Bicarbonate secretion was related to plasma secretion concentration, and a marked stimulatory effect of secretin was found in very low, probably physiological, plasma concentrations. Maximal bicarbonate output was obtained at a plasma concentration of secretin about 20 pmol/l. Glucagon was infused at a rate of 1.0 μg/kg/h and did not influence secretion rate or cell morphology. Also large doses of 5.0 and 50.0 μg/kg/h had no effect on Brunner's gland secretion. It is concluded that secretin in very low plasma concentrations stimulates secretion of bicarbonate, protein and mucus from Brunner's glands in the rat, while glucagon has no effect, and it is suggested that secretin may be involved in the physiological regulation of Brunner's gland secretion.

UR - http://www.scopus.com/inward/record.url?scp=0021212950&partnerID=8YFLogxK

U2 - 10.1136/gut.25.3.264

DO - 10.1136/gut.25.3.264

M3 - Journal article

C2 - 6698442

AN - SCOPUS:0021212950

VL - 25

SP - 264

EP - 268

JO - Gut

JF - Gut

SN - 0017-5749

IS - 3

ER -