Downregulation of Kv7.4 channel activity in primary and secondary hypertension
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators of vascular tone; however, nothing is known about the functional impact of these channels in vascular disease. We ascertained the effect of 3 structurally different activators of Kv7.2 through Kv7.5 channels (BMS-204352, S-1, and retigabine) on blood vessels from normotensive and hypertensive animals.
Originalsprog | Engelsk |
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Tidsskrift | Circulation |
Vol/bind | 124 |
Udgave nummer | 5 |
Sider (fra-til) | 602-11 |
Antal sider | 10 |
ISSN | 0009-7322 |
DOI | |
Status | Udgivet - 2 aug. 2011 |
ID: 108539339