TY - JOUR

T1 - Does moderate intensity impact exercise and non-impact exercise induce acute changes in collagen biochemical markers related to osteoarthritis?

T2 - An exploratory randomized cross-over trial

AU - Bjerre-bastos, Jonathan J.

AU - Nielsen, H. B.

AU - Andersen, J. R.

AU - Karsdal, Morten

AU - Bay-jensen, Anne-Christine

AU - Boesen, Mikael

AU - Mackey, Abigail L.

AU - Byrjalsen, Inger

AU - Bihlet, Asger R.

PY - 2021

Y1 - 2021

N2 - ObjectiveTo investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis.DesignWe conducted a randomized, cross-over, exploratory clinical study. Twenty subjects with knee osteoarthritis (OA) were randomized, of which twenty completed 30 minutes of cycling and 15 completed 30 minutes of running on days one week apart. Fasting blood samples were taken before, immediately after and 1, 2, 3, and 24 hours after activity was initiated. Midstream spot urine was sampled before and after activity. Serum samples were analyzed for concentrations of fragment of type II collagen degradation, C2M, fragment of type VI collagen degradation, C6M, cartilage oligomeric matrix protein, COMP, marker of type II collagen formation, PRO-C2, and urine for marker of crosslinked type II collagen degradation, CTX-II. To establish a reference, all subjects had similar samples taken during rest on a separate day. Data was analyzed in a restricted maximum likelihood based random effects linear mixed model.ResultsC2M trended to increase after cycling compared running (13.49%, 95%CI: -0.36 to 27.34%) and resting (12.88%, 95%CI: 0.2 to 25.6%) and the type II collagen formation/degradation ratio switched towards degradation after cycling, but not running. C6M trended to decrease after cycling (-8.1%, 95%CI: -14.8 to -1.4%) and running (-6.8%, 95%CI: -14.16 to 0.55%).ConclusionIn persons with knee OA moderate intensity exercise without joint impact may induce acute changes in circulating levels of biochemical markers reflecting type II and VI collagen degradation.

AB - ObjectiveTo investigate acute changes in biochemical markers of cartilage turnover in response to moderate intensity exercise with and without joint impact in humans with knee osteoarthritis.DesignWe conducted a randomized, cross-over, exploratory clinical study. Twenty subjects with knee osteoarthritis (OA) were randomized, of which twenty completed 30 minutes of cycling and 15 completed 30 minutes of running on days one week apart. Fasting blood samples were taken before, immediately after and 1, 2, 3, and 24 hours after activity was initiated. Midstream spot urine was sampled before and after activity. Serum samples were analyzed for concentrations of fragment of type II collagen degradation, C2M, fragment of type VI collagen degradation, C6M, cartilage oligomeric matrix protein, COMP, marker of type II collagen formation, PRO-C2, and urine for marker of crosslinked type II collagen degradation, CTX-II. To establish a reference, all subjects had similar samples taken during rest on a separate day. Data was analyzed in a restricted maximum likelihood based random effects linear mixed model.ResultsC2M trended to increase after cycling compared running (13.49%, 95%CI: -0.36 to 27.34%) and resting (12.88%, 95%CI: 0.2 to 25.6%) and the type II collagen formation/degradation ratio switched towards degradation after cycling, but not running. C6M trended to decrease after cycling (-8.1%, 95%CI: -14.8 to -1.4%) and running (-6.8%, 95%CI: -14.16 to 0.55%).ConclusionIn persons with knee OA moderate intensity exercise without joint impact may induce acute changes in circulating levels of biochemical markers reflecting type II and VI collagen degradation.

U2 - 10.1016/j.joca.2021.02.569

DO - 10.1016/j.joca.2021.02.569

M3 - Journal article

C2 - 33676014

VL - 29

SP - 986

EP - 994

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

SN - 1063-4584

IS - 7

ER -