Design and synthesis of a stable oxidized phospholipid mimic with specific binding recognition for macrophage scavenger receptors
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Journal of Medicinal Chemistry |
Vol/bind | 55 |
Udgave nummer | 18 |
Sider (fra-til) | 8178-82 |
Antal sider | 5 |
ISSN | 0022-2623 |
DOI | |
Status | Udgivet - 27 sep. 2012 |
ID: 47720152