Cytokines and beta-cell biology: from concept to clinical translation

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Standard

Cytokines and beta-cell biology: from concept to clinical translation. / Donath, M.Y.; Storling, J.; Berchtold, L.A.; Billestrup, N.; Mandrup-Poulsen, T.

I: Endocrine Reviews, Bind 29, Nr. 3, 2007, s. 334-50.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Donath, MY, Storling, J, Berchtold, LA, Billestrup, N & Mandrup-Poulsen, T 2007, 'Cytokines and beta-cell biology: from concept to clinical translation', Endocrine Reviews, bind 29, nr. 3, s. 334-50. https://doi.org/10.1210/er.2007-0033

APA

Donath, M. Y., Storling, J., Berchtold, L. A., Billestrup, N., & Mandrup-Poulsen, T. (2007). Cytokines and beta-cell biology: from concept to clinical translation. Endocrine Reviews, 29(3), 334-50. https://doi.org/10.1210/er.2007-0033

Vancouver

Donath MY, Storling J, Berchtold LA, Billestrup N, Mandrup-Poulsen T. Cytokines and beta-cell biology: from concept to clinical translation. Endocrine Reviews. 2007;29(3):334-50. https://doi.org/10.1210/er.2007-0033

Author

Donath, M.Y. ; Storling, J. ; Berchtold, L.A. ; Billestrup, N. ; Mandrup-Poulsen, T. / Cytokines and beta-cell biology: from concept to clinical translation. I: Endocrine Reviews. 2007 ; Bind 29, Nr. 3. s. 334-50.

Bibtex

@article{ddf69510acd111ddb538000ea68e967b,
title = "Cytokines and beta-cell biology: from concept to clinical translation",
abstract = "The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.",
author = "M.Y. Donath and J. Storling and L.A. Berchtold and N. Billestrup and T. Mandrup-Poulsen",
note = "Keywords: Animals; Cytokines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Insulin-Secreting Cells; Pancreatitis; Signal Transduction",
year = "2007",
doi = "10.1210/er.2007-0033",
language = "English",
volume = "29",
pages = "334--50",
journal = "Endocrine Reviews",
issn = "0163-769X",
publisher = "The/Endocrine Society",
number = "3",

}

RIS

TY - JOUR

T1 - Cytokines and beta-cell biology: from concept to clinical translation

AU - Donath, M.Y.

AU - Storling, J.

AU - Berchtold, L.A.

AU - Billestrup, N.

AU - Mandrup-Poulsen, T.

N1 - Keywords: Animals; Cytokines; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Humans; Insulin-Secreting Cells; Pancreatitis; Signal Transduction

PY - 2007

Y1 - 2007

N2 - The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.

AB - The tale of cytokines and the beta-cell is a long story, starting with in vitro discovery in 1984, evolving via descriptive and phenomenological studies to detailed mapping of the signalling pathways, gene- and protein expression patterns, molecular and biochemical effector mechanisms to in vivo studies in spontaneously diabetic and transgenic animal models. Only very recently have steps been taken to translate the accumulating compelling preclinical data into clinical trials. The aim of this chapter is to present an overview of early and recent key observations from our own groups as well as other laboratories that serve to illuminate the road from concept to clinical translation.

U2 - 10.1210/er.2007-0033

DO - 10.1210/er.2007-0033

M3 - Journal article

C2 - 18048762

VL - 29

SP - 334

EP - 350

JO - Endocrine Reviews

JF - Endocrine Reviews

SN - 0163-769X

IS - 3

ER -

ID: 8465580