TY - JOUR

T1 - Circulating Plasma Oxytocin Level Is Elevated by High-Intensity Interval Exercise in Men

AU - Tsukamoto, Hayato

AU - Olesen, Niels D.

AU - Petersen, Lonnie G.

AU - Suga, Tadashi

AU - Sørensen, Henrik

AU - Nielsen, Henning B.

AU - Ogoh, Shigehiko

AU - Secher, Niels H.

AU - Hashimoto, Takeshi

N1 - Publisher Copyright: © 2024 Lippincott Williams & Wilkins.

PY - 2024

Y1 - 2024

N2 - Purpose We evaluated whether repeated high-intensity interval exercise (HIIE) influences plasma oxytocin (OT) concentration in healthy men, and, given that OT is mainly synthesized in the hypothalamus, we assessed the concentration difference between the arterial (OTART) versus the internal jugular venous OT concentration (OTIJV). Additionally, we hypothesized that an increase in cerebral OT release and the circulating concentration would be augmented by repeated HIIE. Methods Fourteen healthy men (age = 24 ± 2 yr; mean ± SD) performed two identical bouts of HIIE. These HIIE bouts included a warm-up at 50%-60% maximal workload (Wmax) for 5 min followed by four bouts of exercise at 80%-90% Wmax for 4 min interspersed by exercise at 50%-60% Wmax for 3 min. The HIIE bouts were separated by 60 min of rest. OT was evaluated in blood through radial artery and internal jugular vein catheterization. Results Both HIIE bouts increased both OTART (median [IQR], from 3.9 [3.4-5.4] to 5.3 [4.4-6.3] ng·mL-1 in the first HIIE, P < 0.01) and OTIJV (from 4.6 [3.4-4.8] to 5.9 [4.3-8.2] ng·mL-1, P < 0.01), but OTART-IJV was unaffected (from -0.24 [-1.16 to 1.08] to 0.04 [-0.88 to 0.78] ng·mL-1, P = 1.00). The increased OT levels were similar in the first and second HIIE bouts (OTART P = 0.25, OTIJV P = 0.36). Conclusions Despite no change in the cerebral OT release via the internal jugular vein, circulating OT increases during HIIE regardless of the accumulated exercise volume, indicating that OT may play role as one of the exerkines.

AB - Purpose We evaluated whether repeated high-intensity interval exercise (HIIE) influences plasma oxytocin (OT) concentration in healthy men, and, given that OT is mainly synthesized in the hypothalamus, we assessed the concentration difference between the arterial (OTART) versus the internal jugular venous OT concentration (OTIJV). Additionally, we hypothesized that an increase in cerebral OT release and the circulating concentration would be augmented by repeated HIIE. Methods Fourteen healthy men (age = 24 ± 2 yr; mean ± SD) performed two identical bouts of HIIE. These HIIE bouts included a warm-up at 50%-60% maximal workload (Wmax) for 5 min followed by four bouts of exercise at 80%-90% Wmax for 4 min interspersed by exercise at 50%-60% Wmax for 3 min. The HIIE bouts were separated by 60 min of rest. OT was evaluated in blood through radial artery and internal jugular vein catheterization. Results Both HIIE bouts increased both OTART (median [IQR], from 3.9 [3.4-5.4] to 5.3 [4.4-6.3] ng·mL-1 in the first HIIE, P < 0.01) and OTIJV (from 4.6 [3.4-4.8] to 5.9 [4.3-8.2] ng·mL-1, P < 0.01), but OTART-IJV was unaffected (from -0.24 [-1.16 to 1.08] to 0.04 [-0.88 to 0.78] ng·mL-1, P = 1.00). The increased OT levels were similar in the first and second HIIE bouts (OTART P = 0.25, OTIJV P = 0.36). Conclusions Despite no change in the cerebral OT release via the internal jugular vein, circulating OT increases during HIIE regardless of the accumulated exercise volume, indicating that OT may play role as one of the exerkines.

KW - BRAIN METABOLISM

KW - CARDIOVASCULAR HEALTH

KW - EXERCISE

KW - EXERKINE

KW - MENTAL HEALTH

KW - NEUROPEPTIDE

U2 - 10.1249/MSS.0000000000003360

DO - 10.1249/MSS.0000000000003360

M3 - Journal article

C2 - 38115226

AN - SCOPUS:85190754620

VL - 56

SP - 927

EP - 932

JO - Medicine and Science in Sports and Exercise

JF - Medicine and Science in Sports and Exercise

SN - 0195-9131

IS - 5

ER -