Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans
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Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans. / Battram, D S; Graham, T E; Dela, F.
I: Journal of Physiology, Bind 583, Nr. Pt 3, 2007, s. 1069-77.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Caffeine's impairment of insulin-mediated glucose disposal cannot be solely attributed to adrenaline in humans
AU - Battram, D S
AU - Graham, T E
AU - Dela, F
N1 - Keywords: Adult; Blood Glucose; Blood Pressure; Caffeine; Central Nervous System Stimulants; Drug Interactions; Epinephrine; Fatty Acids, Nonesterified; Heart Rate; Humans; Hyperinsulinism; Insulin; Male
PY - 2007
Y1 - 2007
N2 - Caffeine (CAF) impedes insulin-mediated glucose disposal (IMGD) and increases plasma adrenaline concentrations ([ADR]; 0.6 nm). While the antagonism of ADR abolishes the CAF effect, infusion of ADR (0.75 nm) has no effect on IMGD. We have now examined CAF and ADR in concert to determine whether or not they elicit an additive response on IMGD. We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR). Subjects (n = 8) completed four trials in a randomized manner. An isoglycaemic-hyperinsulinaemic clamp was performed 30 min after the following treatments were administered: (1) placebo capsules and saline infusion ([ADR] = 0.29 nm) (PL trial), (2) CAF capsules (dose = 5 mg kg(-1)) and saline infusion ([ADR] = 0.62 nm) (CAF trial), (3) PL capsules and ADR infusion ([ADR] = 1.19 nm) (ADR trial), and (4) CAF capsules (dose = 5 mg kg(-1)) and ADR infusion ([ADR] = 0.93 nm) (CAF + ADR trial). As expected, CAF, ADR and CAF + ADR decreased (P
AB - Caffeine (CAF) impedes insulin-mediated glucose disposal (IMGD) and increases plasma adrenaline concentrations ([ADR]; 0.6 nm). While the antagonism of ADR abolishes the CAF effect, infusion of ADR (0.75 nm) has no effect on IMGD. We have now examined CAF and ADR in concert to determine whether or not they elicit an additive response on IMGD. We hypothesized that CAF + ADR would elicit a greater effect than either CAF or ADR alone (i.e. that CAF effects would not be solely attributed to ADR). Subjects (n = 8) completed four trials in a randomized manner. An isoglycaemic-hyperinsulinaemic clamp was performed 30 min after the following treatments were administered: (1) placebo capsules and saline infusion ([ADR] = 0.29 nm) (PL trial), (2) CAF capsules (dose = 5 mg kg(-1)) and saline infusion ([ADR] = 0.62 nm) (CAF trial), (3) PL capsules and ADR infusion ([ADR] = 1.19 nm) (ADR trial), and (4) CAF capsules (dose = 5 mg kg(-1)) and ADR infusion ([ADR] = 0.93 nm) (CAF + ADR trial). As expected, CAF, ADR and CAF + ADR decreased (P
U2 - 10.1113/jphysiol.2007.130526
DO - 10.1113/jphysiol.2007.130526
M3 - Journal article
C2 - 17656440
VL - 583
SP - 1069
EP - 1077
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - Pt 3
ER -
ID: 12771939