beta-Arrestin 1 and 2 stabilize the angiotensin II type I receptor in distinct high-affinity conformations
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The angiotensin II type 1 (AT(1)) receptor belongs to family A of 7 transmembrane (7TM) receptors. The receptor has important roles in the cardiovascular system and is commonly used as a drug target in cardiovascular diseases. Interaction of 7TM receptors with G proteins or beta-arrestins often induces higher binding affinity for agonists. Here, we examined interactions between AT(1A) receptors and beta-arrestins to look for differences between the AT(1A) receptor interaction with beta-arrestin1 and beta-arrestin2.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Pharmacology |
Vol/bind | 161 |
Udgave nummer | 1 |
Sider (fra-til) | 150-61 |
Antal sider | 12 |
ISSN | 0007-1188 |
DOI | |
Status | Udgivet - sep. 2010 |
ID: 34167999