Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients
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Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients. / Henningsen, Kristoffer M A; Olesen, Morten S; Haunsoe, Stig; Svendsen, Jesper H.
I: Scandinavian Cardiovascular Journal, Bind 45, Nr. 6, 12.2011, s. 324-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association of rs2200733 at 4q25 with early onset of lone atrial fibrillation in young patients
AU - Henningsen, Kristoffer M A
AU - Olesen, Morten S
AU - Haunsoe, Stig
AU - Svendsen, Jesper H
PY - 2011/12
Y1 - 2011/12
N2 - OBJECTIVE: Genome wide association studies have shown an association between rs2200733 at 4q25 and atrial fibrillation (AF). In this case-control study we investigate the association of rs2200733 and lone AF in young patients.METHODS: We included 196 young patients with lone AF and the first episode before the age of 40 years. We analyzed the single nucleotide polymorphism (SNP) rs2200733 for the lone AF patients and compared them to a control group of 176 age matched healthy individuals.RESULTS: No significant differences, in neither genotype distribution, nor minor allele frequencies were found between the lone AF patients and the healthy controls.CONCLUSION: Our results suggest that the rs220733 is not a risk factor for AF in patients with no other cardiovascular disease and with early onset of the arrhythmia.
AB - OBJECTIVE: Genome wide association studies have shown an association between rs2200733 at 4q25 and atrial fibrillation (AF). In this case-control study we investigate the association of rs2200733 and lone AF in young patients.METHODS: We included 196 young patients with lone AF and the first episode before the age of 40 years. We analyzed the single nucleotide polymorphism (SNP) rs2200733 for the lone AF patients and compared them to a control group of 176 age matched healthy individuals.RESULTS: No significant differences, in neither genotype distribution, nor minor allele frequencies were found between the lone AF patients and the healthy controls.CONCLUSION: Our results suggest that the rs220733 is not a risk factor for AF in patients with no other cardiovascular disease and with early onset of the arrhythmia.
KW - Adult
KW - Age of Onset
KW - Atrial Fibrillation/diagnosis
KW - Case-Control Studies
KW - Chi-Square Distribution
KW - Chromosomes, Human, Pair 4
KW - Denmark/epidemiology
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Humans
KW - Logistic Models
KW - Odds Ratio
KW - Phenotype
KW - Polymorphism, Single Nucleotide
KW - Risk Assessment
KW - Risk Factors
U2 - 10.3109/14017431.2011.594081
DO - 10.3109/14017431.2011.594081
M3 - Journal article
C2 - 21793630
VL - 45
SP - 324
EP - 326
JO - Scandinavian Cardiovascular Journal
JF - Scandinavian Cardiovascular Journal
SN - 1401-7458
IS - 6
ER -
ID: 196039835