AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells

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Standard

AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells. / Josefsen, Knud; Lee, Ying C; Thams, Peter; Efendic, Suad; Nielsen, Jens H.

I: FEBS Letters, Bind 584, Nr. 1, 01.2010, s. 81-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Josefsen, K, Lee, YC, Thams, P, Efendic, S & Nielsen, JH 2010, 'AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells', FEBS Letters, bind 584, nr. 1, s. 81-5. https://doi.org/10.1016/j.febslet.2009.10.086

APA

Josefsen, K., Lee, Y. C., Thams, P., Efendic, S., & Nielsen, J. H. (2010). AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells. FEBS Letters, 584(1), 81-5. https://doi.org/10.1016/j.febslet.2009.10.086

Vancouver

Josefsen K, Lee YC, Thams P, Efendic S, Nielsen JH. AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells. FEBS Letters. 2010 jan.;584(1):81-5. https://doi.org/10.1016/j.febslet.2009.10.086

Author

Josefsen, Knud ; Lee, Ying C ; Thams, Peter ; Efendic, Suad ; Nielsen, Jens H. / AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells. I: FEBS Letters. 2010 ; Bind 584, Nr. 1. s. 81-5.

Bibtex

@article{ea4810e0d12911df825b000ea68e967b,
title = "AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells",
abstract = "A-kinase anchoring proteins (AKAPs) are known to compartmentalise protein kinase(s) to discrete cellular locations. Here we show that silencing of AKAP 18 alpha or gamma expression results in decreased or increased glucose-stimulated insulin secretion in INS-1E cells. Glucose stimulates AKAP 18 alpha and inhibits AKAP 18 gamma mRNA expressions while palmitate markedly reduces AKAP 18 alpha expression. Human growth hormone (GH) stimulates AKAP 18 alpha expression and attenuates palmitate-induced suppression of AKAP 18 alpha mRNA level. The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.",
author = "Knud Josefsen and Lee, {Ying C} and Peter Thams and Suad Efendic and Nielsen, {Jens H}",
note = "Keywords: Animals; Carrier Proteins; Cell Line, Tumor; Glucose; Growth Hormone; Insulin; Insulin-Secreting Cells; Rats; Transcription, Genetic",
year = "2010",
month = jan,
doi = "10.1016/j.febslet.2009.10.086",
language = "English",
volume = "584",
pages = "81--5",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells

AU - Josefsen, Knud

AU - Lee, Ying C

AU - Thams, Peter

AU - Efendic, Suad

AU - Nielsen, Jens H

N1 - Keywords: Animals; Carrier Proteins; Cell Line, Tumor; Glucose; Growth Hormone; Insulin; Insulin-Secreting Cells; Rats; Transcription, Genetic

PY - 2010/1

Y1 - 2010/1

N2 - A-kinase anchoring proteins (AKAPs) are known to compartmentalise protein kinase(s) to discrete cellular locations. Here we show that silencing of AKAP 18 alpha or gamma expression results in decreased or increased glucose-stimulated insulin secretion in INS-1E cells. Glucose stimulates AKAP 18 alpha and inhibits AKAP 18 gamma mRNA expressions while palmitate markedly reduces AKAP 18 alpha expression. Human growth hormone (GH) stimulates AKAP 18 alpha expression and attenuates palmitate-induced suppression of AKAP 18 alpha mRNA level. The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.

AB - A-kinase anchoring proteins (AKAPs) are known to compartmentalise protein kinase(s) to discrete cellular locations. Here we show that silencing of AKAP 18 alpha or gamma expression results in decreased or increased glucose-stimulated insulin secretion in INS-1E cells. Glucose stimulates AKAP 18 alpha and inhibits AKAP 18 gamma mRNA expressions while palmitate markedly reduces AKAP 18 alpha expression. Human growth hormone (GH) stimulates AKAP 18 alpha expression and attenuates palmitate-induced suppression of AKAP 18 alpha mRNA level. The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.

U2 - 10.1016/j.febslet.2009.10.086

DO - 10.1016/j.febslet.2009.10.086

M3 - Journal article

C2 - 19896945

VL - 584

SP - 81

EP - 85

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 1

ER -

ID: 22361195