Age-related decline in mitral peak diastolic velocities is unaffected in well-trained runners
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Age-related decline in mitral peak diastolic velocities is unaffected in well-trained runners. / Olsen, Rasmus Huan; Couppé, Christian; Dall, Christian Have; Monk-Hansen, Tea; Mikkelsen, Ulla Ramer; Karlsen, Anders; Høst, Nis Baun; Magnusson, S Peter; Prescott, Eva.
I: Scandinavian Cardiovascular Journal, Bind 49, Nr. 4, 08.2015, s. 183-92.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Age-related decline in mitral peak diastolic velocities is unaffected in well-trained runners
AU - Olsen, Rasmus Huan
AU - Couppé, Christian
AU - Dall, Christian Have
AU - Monk-Hansen, Tea
AU - Mikkelsen, Ulla Ramer
AU - Karlsen, Anders
AU - Høst, Nis Baun
AU - Magnusson, S Peter
AU - Prescott, Eva
PY - 2015/8
Y1 - 2015/8
N2 - OBJECTIVES: We examined whether diastolic left ventricular function in young and senior lifelong endurance runners was significantly different from that in sedentary age-matched controls, and whether lifelong endurance running appears to modify the age-related decline in diastolic left ventricular function.DESIGN: The study comprised 17 senior athletes (age: 59-75 years, running distance: 30-70 km/week), 10 young athletes (age: 20-36 years, matched for running distance), and 11 senior and 12 young weight-matched sedentary controls. Peak early (E) and late (A) mitral inflow and early (e') and late (a') diastolic and systolic (s') annular longitudinal tissue Doppler velocities were measured by echocardiography during four stages (rest, supine bike exercise at 30% and 60% of maximal workload, and recovery).RESULTS: The athletes had marked cardiac remodeling, while overall differences in mitral inflow and annular tissue Doppler velocities during rest and exercise were more associated with age than with training status. The senior participants had lower E/A at rest, overall lower E, e' and s', and greater E/e' compared to the young participants (all values of P < 0.05). The athletes had greater E/A (P = 0.004), but tissue Doppler velocities were not different from those of the controls.CONCLUSIONS: Lifelong endurance running was not found to be associated with major attenuation of the age-related decline in diastolic function at rest or during exercise.
AB - OBJECTIVES: We examined whether diastolic left ventricular function in young and senior lifelong endurance runners was significantly different from that in sedentary age-matched controls, and whether lifelong endurance running appears to modify the age-related decline in diastolic left ventricular function.DESIGN: The study comprised 17 senior athletes (age: 59-75 years, running distance: 30-70 km/week), 10 young athletes (age: 20-36 years, matched for running distance), and 11 senior and 12 young weight-matched sedentary controls. Peak early (E) and late (A) mitral inflow and early (e') and late (a') diastolic and systolic (s') annular longitudinal tissue Doppler velocities were measured by echocardiography during four stages (rest, supine bike exercise at 30% and 60% of maximal workload, and recovery).RESULTS: The athletes had marked cardiac remodeling, while overall differences in mitral inflow and annular tissue Doppler velocities during rest and exercise were more associated with age than with training status. The senior participants had lower E/A at rest, overall lower E, e' and s', and greater E/e' compared to the young participants (all values of P < 0.05). The athletes had greater E/A (P = 0.004), but tissue Doppler velocities were not different from those of the controls.CONCLUSIONS: Lifelong endurance running was not found to be associated with major attenuation of the age-related decline in diastolic function at rest or during exercise.
KW - Adult
KW - Age Factors
KW - Aged
KW - Aging
KW - Bicycling
KW - Case-Control Studies
KW - Cross-Sectional Studies
KW - Diastole
KW - Echocardiography, Doppler
KW - Exercise Test
KW - Humans
KW - Male
KW - Middle Aged
KW - Mitral Valve
KW - Physical Endurance
KW - Running
KW - Ventricular Function, Left
KW - Young Adult
U2 - 10.3109/14017431.2015.1049654
DO - 10.3109/14017431.2015.1049654
M3 - Journal article
C2 - 25968969
VL - 49
SP - 183
EP - 192
JO - Scandinavian Cardiovascular Journal
JF - Scandinavian Cardiovascular Journal
SN - 1401-7458
IS - 4
ER -
ID: 160445498